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RISS 인기검색어
- 검색키워드
- 저자 : 진가현(Ga Hyun Jin) (검색결과 2 건)
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진가현 ( Ga Hyun Jin ),김수명 ( Su Myung Kim ),강탁림 ( Tak Lim Kang ),김동희 ( Dong Hee Kim ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.1
N/A Objectives : To evaluate the antitumor activity and antimetastatic effects of Cheongyoelhaedokbang(CHB), studies were done experimentally. Method : The study was carried out to evaluate antitumor activity, cytotoxicity, topoisomerase 1 activity, apoptosis and T/C% were measured, and also pulmonary colonization and histological changes of lung in B16-F10 injceted mice, levels of blood vessel formation in the CAM assay and platelet coagulation were measured to prove antimetastatic effects. Results : The results were obtained as follows 1. Treatment of CHB showed cytotoxic effect on A549, SK-OV-3, NIH: OVCAR-3, MCF-7 and MDA-MB-231 cancer cell line by 40% or higher than non-treated control cells at conc. of 100 ㎍/ml. 2. IC_50 value for the inhibition of topoisomerase 1 enzyme activity by CHB was 50-100 ㎍/ml. 3. Treatment of Jurkat cells with CHB and FACS analysis didn`t showed significant changes compared to non-treated control cells. 4. The T/C% was 127.65% in treatment of CHB in S-180 hearing ICR mice. 5. CHB treatment inhibited the adhesion of A549, SK-OV-3 cancer cell line to the complex substrates of culture dish surface. Cell detachment with CHB treatment (100 ㎍/ml) was higher than 40% compared to non-treated control cells. 6. In pulmonary colonization assay, a number of colonies in the lungs were decreased significantly in treatment of CHB compared to non-treated control cells. 7. In the histological changes of lung in B16-F10 injected mice, infiltration area of cancer cells were inhibited effectively in CHB treated group and also infiltration of lymphocytes were shown in pulmonary vein of CHB treated group. 8. In the CAM assay by which the levels of blood vessel formation can be determined quantitatively, CHB treatment inhibited vessel formation by 50%. 9. CHB treatment (10 ㎍/ml or higher concentrations) completely inhibited platelet coagulation by ADP. And also inhibited platelet coagulation by epinephrine in dose dependent manner. Conclusion : From above results it was concluded that CHB could be usefully applied for the prevention and treatment of cancer. and it is still necessary to research on synergic effect with key prescreptions in relation to cancer therapy in oriental medicine
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