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랫드에서 매미눈꽃동충하초 , Paecilomyces sinclairii의 13주 반복투여 독성에 관한 연구
안미영(Mi Young Ahn),지상덕(Sang Duk Jee),김지염(Ji Young Kim),한재웅(Jea Woong Han),이용기(Yong Ki Lee),이용우(Yong Woo Lee),류강선(Kang Sun Ryu),이병무(Byung Mu Lee),정나진(Na Jin Jung),김성남(Sung Nam Kim) 한국독성학회 2004 Toxicological Research Vol.20 No.4
Paecilomyces sinclairii was administered ad libitum feeding at percentage levels of 0, 1.25, 2.5, 5 and 10 percentage (calculated about 8 g/kg)/feeder for a period of 3 months. There was no observed clinical signs or deaths related to treatment in all groups tested. Therefore, the approximate lethal dose of P. sinclairii was considered to be higher than 8 g/kg in rats. Mild decreases in body weight gain were observed dose-dependently in P. sinclairii treated groups in dose response manner after 2 weeks. Interestingly, the weight of abdominal adipose tissues surrounding epididymides were greatly reduced by this Dongchunghacho, in parallel with the mild increase in body weight gain. However, the absolute weight change of other organs was not observed. There were not significantly different from the control group in urinalysis, ocular examination, hematological, serum biochemical value and histopathological examination. From these results, it is concluded that the no-observedadverse-effect level (NOAEL) of P. sinclairii is less than 1.25% (1 g/kg) in rats in the present study.
비글개에 대한 Paecilomyces sinclairii의 급성 경구독성에 관한 연구
안미영(Mi Young Ahn),강세찬(Se Chan Kang),정나진(Na Jin Jung),구현정(Hyun Jung Koo),곽승준(Seung Jun Kwack),유은정(Eun Jung Yoo),정진아(Jin A Jung),고진경(Jin Kyung Ko),류강선(Kang Sun Ryu),지상덕(Sang Duk Jee),이용우(Yong Woo Lee),이 한국독성학회 2003 Toxicological Research Vol.19 No.3
The acute toxicity of Paecilomyces sinclairii was tested in beagle dogs. We daily examined clinical signs, body weights, and hematological/ biochemical examinations for 14 days after<br/> administration of Paecilomyces sinclairii with different dose levels (0, 0.4, 2 and 10 g/kg). There were no clinical signs and no significant changes in hematological and biochemical analysis. These results showed that Paecilomyces sinclairii did not induce any remarkable acute toxic response and the LD50 was greater than 10 g/kg in beagle dogs.