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랫드에서 매미눈꽃동충하초 , Paecilomyces sinclairii의 13주 반복투여 독성에 관한 연구
안미영(Mi Young Ahn),지상덕(Sang Duk Jee),김지염(Ji Young Kim),한재웅(Jea Woong Han),이용기(Yong Ki Lee),이용우(Yong Woo Lee),류강선(Kang Sun Ryu),이병무(Byung Mu Lee),정나진(Na Jin Jung),김성남(Sung Nam Kim) 한국독성학회 2004 Toxicological Research Vol.20 No.4
Paecilomyces sinclairii was administered ad libitum feeding at percentage levels of 0, 1.25, 2.5, 5 and 10 percentage (calculated about 8 g/kg)/feeder for a period of 3 months. There was no observed clinical signs or deaths related to treatment in all groups tested. Therefore, the approximate lethal dose of P. sinclairii was considered to be higher than 8 g/kg in rats. Mild decreases in body weight gain were observed dose-dependently in P. sinclairii treated groups in dose response manner after 2 weeks. Interestingly, the weight of abdominal adipose tissues surrounding epididymides were greatly reduced by this Dongchunghacho, in parallel with the mild increase in body weight gain. However, the absolute weight change of other organs was not observed. There were not significantly different from the control group in urinalysis, ocular examination, hematological, serum biochemical value and histopathological examination. From these results, it is concluded that the no-observedadverse-effect level (NOAEL) of P. sinclairii is less than 1.25% (1 g/kg) in rats in the present study.