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생명유전자 목양회복과 건강체 사역 : 세린교회의 셀 사역이야기
주성훈 장로회신대학교 2004 敎會와 神學 Vol.59 No.-
세린목회는 셀 공동체 통합 사역이다. 이는 신약성경에서 보여주는고 있는 하나님의 목적(마 28:19-20)하에 시작된 생명체구조와 건강체구조를 통한 교회화목 운동이다. 생명체란 생명체 신앙이 회복된 사람들을 말한다. 그것은 한 알의 희생밀알을 통해 제자공동체가 형성이 되는 것과 우리가 살고 있는 삶의 현장을 건강한 이웃관계로 만들어 가는 것이다. 이는 교회의 두 구조사역을 말하는 바, 하나는 교회가 영혼구원에 초점을 맞춘 전도 실천 사역으로서, 이는 누구든지 생명을 살리는 경험을 통해 예수님의 제자소그룹을 형성하여 지속적인 제자공동체로 실천하는 사역이다. 또 다른 하나는 건강 공동체 사역 즉, 12제자사역으로 하나님의 피조체들이 그 은사를 토대로 지체적 기능을 통하여 이웃을 향한 섬김의 생활로 교회의 역할을 실천함으로써 주님이 주신 건강체질을 이루어가는 것이다. 이는 바로 아버지의 뜻이 하늘에서 이루어진 것같이 땅에서도 이루어진다는 성경 말씀의 기초하는 것으로 두 구조의 목회 방향인 하나님의 신령한 영성구원의 백성을 만들어 내는 생명체사역과 하나님이 주신 은사를 발견하여 이를 통한 네트워크 사역을 말한다.
후천면역결핍 증후군 관련 진행성 다초점 백색질 뇌증에서 항레트로바이러스 치료로 유발된 면역재구성증후군 1예
주성훈,김태형,나정식,송호섭,유인규,윤희정 대한감염학회 2010 감염과 화학요법 Vol.42 No.3
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system due to JC virus. In acquired immunodeficiency syndrome (AIDS) patients, JC virus infects myelin-producing oligodendrocytes causing a noninflammatory lytic reaction leading to demyelination and brain death. We herein report a case of a 56-years-old AIDS man who developed immune reconstitution inflammatory syndrome and died while undergoing highly active antiretroviral therapy. In this patient, the PML involved the brainstem, causing mental confusion followed by recurrent aspiration, adult respiratory distress syndrome, and eventually to early death.
주성훈,김태형,나정식,송호섭,유인규,윤희정 대한감염학회 2010 Infection and Chemotherapy Vol.42 No.3
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system due to JC virus. In acquired immunodeficiency syndrome (AIDS) patients, JC virus infects myelin-producing oligodendrocytes causing a noninflammatory lytic reaction leading to demyelination and brain death. We herein report a case of a 56-years-old AIDS man who developed immune reconstitution inflammatory syndrome and died while undergoing highly active antiretroviral therapy. In this patient, the PML involved the brainstem, causing mental confusion followed by recurrent aspiration, adult respiratory distress syndrome, and eventually to early death.
주성훈,임지순,남윤기 한국바이오칩학회 2018 BioChip Journal Vol.12 No.3
Dissociated neuronal cultures combined with planar-type microelectrode arrays (MEAs) have been used as a promising read-out platform for the application of cell-based biosensors. There are increasing interests in engineering neuronal cultures to form the desired network topology by surface micropatterning technology. Here, we report a long-term cultivation of primary hippocampal neurons on microelectrode arrays using soft-lithography. Ordered hippocampal neuronal networks were formed by seeding neurons in agarose-microwells and inducing neurite outgrowth through microgrooves. Unlike previous approaches, our technique allowed us to design networks with various microwells on microelectrode arrays with high repeatability. These hippocampal network chips were cultivated for 30 days with excellent pattern fidelity, and neural spikes were successfully measured. We also found that spontaneous activity of the networks could be enhanced by acute disinhibition of inhibitory synapses. The proposed patterning method for neuronal network chips will be a potentially powerful tool for cell-based drug-screening applications.
Recent Trends in Microelectrode Array Technology for In Vitro Neural Interface Platform
김래영,주성훈,Hyunjun Jung,홍나리,남윤기 대한의용생체공학회 2014 Biomedical Engineering Letters (BMEL) Vol.4 No.2
Microelectrode array (MEA) technology is a widely usedplatform for the study of in vitro neural networks as it caneither record or stimulate neurons by accessing multiple sitesof neural circuits simultaneously. Unlike intracellular recordingtechniques, MEAs form noninvasive interface with cells sothat they provides relatively long time window for studyingneural circuits. As the technology matured, there have beenvarious engineering solutions to meet the requirements indiverse application areas of MEAs: High-density MEAs,high-throughput platforms, flexible electrodes, monitoringsubthreshold activity, co-culture platforms, and surfacemicropatterning. The MEA technology has been applied toneural network analysis, drug screening and neural prosthesesstudies. In this paper, the MEA technology is reviewed andthe future prospect is discussed.