급성뇌경색증으로 발현된 심장점액종 소아 1례

주명돈,이경원 대한응급의학회 2012 大韓應急醫學會誌 Vol.23 No.2

Occurrence of primary cardiac tumors is rare in all age groups; occurrence is observed in 0.05% of routine postmortem examinations. A 15-year-old Korean female transported by 119 rescue presented with common clinical findings for acute stroke. Brain imaging included computed tomography; magnetic resonance imaging was performed in the emergency department. Findings on brain imaging were compatible with acute cerebral infarction of the territory of the right middle cerebral artery. The patient was treated with reperfusion therapy with IV tissue plasminogen activator and cerebral artery stenting. Echocardiography was performed in the emergency department in order to determine the cause of acute cerebral infarction. We experienced a case of pediatric cardiac myxoma presenting as an acute stroke in the emergency department, which was confirmed by imaging study and biopsy; therefore, we report on it here along with a review of the literature.

오심과 구토를 주소로 응급실로 내원한, 빠르게 진행한 Takayasu 동맥염 1례

주명돈,이경원 대한응급의학회 2011 대한응급의학회지 Vol.22 No.2

Takayasu’s arteritis is a chronic inflammatory disease involving the aorta and the arteries arising from the aorta. The pulmonary arteries also may be involved. The inflammation leads to either stenosis and occlusion of the involved artery or formation of aneurysm or both. The arterial lesions can lead to secondary hypertension, retinopathy, cardiac involvement,cerebrovascular event. The course and prognosis of patients with Takayasu’s arteritis shows wide variation. We experienced a case of rapid growing Takayasu’s arteritis presenting as nausea and vomiting at emergency department,which was confirmed by computed tomography and angiography, so reported it with a review of literature

디메틸포름아미드 노출 후 발생한 독성 간염1례

주명돈,손유동,최우익 대한응급의학회 2006 大韓應急醫學會誌 Vol.17 No.5

급성복증으로 내원한 원발성 복막수염 1례

주명돈,최우익 대한응급의학회 2006 大韓應急醫學會誌 Vol.17 No.2

돌발성 난청환자의 종양괴사인자-알파 유전자 다형성

주명돈(Myung Don Joo),탁기홍(Ki-Hong Tak),남성일(Sung-IL Nam),이동혈(Dong-Hyul Lee),유경임(Kyung-Im Yoo),정인성(In-Sung Chung),이미영(Mi-Young Lee),신동훈(Dong-Hoon Shin),김태완(Tae-Wan Kim) 한국항공우주의학협회 2006 항공우주의학회지 Vol.16 No.3

성인에서 발생한 대망경색 1례

김성진,주명돈,최대해,전덕호,이동필 대한응급의학회 2003 大韓應急醫學會誌 Vol.14 No.4

Ellagic acid 첨가가 소 체외 수정란 생산에 미치는 영향

강선민,주명돈,공일근 경상국립대학교 농업생명과학연구원 2022 농업생명과학연구 Vol.56 No.1

체외 환경에서 생산되는 배아 (Embryo)는 활성산소종 (Reaction oxygen species, ROS) 수준이 일정 수준을 초과함에 따라 산화적인 손상을받게 된다. 선행연구에 따르면, 항산화제는 ROS를 감소시켜주는 효과를 가지기 때문에 ROS로부터 오는 배아의 단백질, DNA의 손상, 세포 자멸사를방지하여 배아의 발달률을 향상시킨다. 이전연구에 따르면 항산화제로써 엘라그산 (Ellagic acid, EA)은 ROS를 효과적으로 제거하고, 난자의산화스트레스를 방지하는 효과를 가지고 있다고 보고되었다. 그리하여, 본 연구를 통해 우리는 소의 수정란 배양체계 중 in vitro culture (IVC) 단계에서 EA의 농도 (0, 5, 10 μM) 별 첨가가 소의 수정란 발달률과, 질적 수준에 미치는 영향을 조사하고자 실험을 진행하였다. 결과적으로, 배반포의 단계별 발달 수준에서 cleavage 형성률은 EA첨가군과 대조군 간의 차이를 발견할 수 없었으나 배반포 형성률에서는 모든 EA 첨가군들이대조군보다 높았고 EA 첨가군 중에 5 μM 첨가군이 가장 높았다 (p < 0.05). 생산된 배반포의 총 세포 수는 5 μM EA 첨가군이 대조군과10 μM EA 첨가군 보다 유의적으로 높았으며, 대조군과 10 μM EA 첨가군 사이의 유의적 차이는 없었다 (Control vs. 5 μM vs. 10 μM; 137 ± 7.90 vs. 163.2 ± 7.42 vs. 138.8 ± 6.67, p < 0.05). 세포 자멸사 세포 수는 모든 EA 첨가군들이 대조군보다 유의적으로 낮았다 (Control vs. 5 μM vs. 10 μM; 22.65 ± 4.08, 9.61 ± 1.55, 6.14 ± 0.90, p < 0.05). ROS 수준에서 모든 EA 첨가군들과 대조군 간의 유의적 차이는없었다 (Control vs. 5 μM vs. 10 μM; 6.81 ± 1.31, 3.86 ± 0.23, 4.11 ± 0.18, p < 0.05). qRT-PCR 실험 결과에서 Nrf2 gene expression은대조군과, 5 μM 첨가군에서 유의적 차이가 없었으나, 10 μM 첨가군에서는 유의적으로 상향 조절된 것을 관찰하였다. Keap1 gene expression은5 μM 첨가군에서 유의적으로 하향 조절된 것을 관찰하였다. 하지만 EA의 농도가 10 μM으로 높아짐에 따라 발현 수준이 증가한 것을 관찰할수 있었다. CAT gene expression은 5 μM 첨가군에서 유의적으로 상향조절 되었으나 10 μM 첨가군에서는 유의적인 차이를 보이지 않았다. SOD1 gene expression은 대조군과 5 μM 첨가군은 유의적인 차이를 보이지 않았으나 10 μM 첨가군에서는 유의적으로 상향 조절된 것을 관찰하였다.

급성 중크롬산 암모늄 중독 1례

최대해,주명돈,전덕호,최우익,이동필 대한응급의학회 2004 大韓應急醫學會誌 Vol.15 No.3

Soluble compounds of chromium are widely used in industrial processes, including printing, photography, pyrotechnics, dyeing, electroplating, aircraft, shipbuilding, and leather tanning. Exposure in industry is generally via the inhalation of dusts and fumes. Ingestion of chromium (chromate or dichromate salt) has occurred accidentally in suicide attempts and during drug experimentation and may causes ulceration of the bowel, diarrhea, hemorrhagic diathesis, acute renal failure, and hepatic damage. Ingestion of hexavalent chromium compounds is considered to be one hundred times more toxic than the trivalent compounds. Chromium poisoning in children is an uncommon, potentially lethal form of poisoning which could possibly increase in incidence because of the resumed greater domestic distribution of dichromate in Korea. We report a case of ammonium dichromate ingestion by a child that resulted in a healthy discharge.

독사 교상 환자에서 전신 증상 및 합병증 발생에 연관된 인자에 대한 연구

진상찬,이제원,양승준,주명돈,최우익 대한응급의학회 2008 대한응급의학회지 Vol.19 No.6

Purpose: Venomous snakebite is an important medical emergency in Korea, but the factors affecting outcomes are unclear. Methods: We conducted an 8-year retrospective study of 169 snake bite patients who visited the emergency departments of Keimyung University at Dongsan Medical Center between January, 2000, and December, 2007. Patients were divided by systemic symptoms and complications (group 1) or local symptoms only (group 2). We compared the general characteristics and clinical and laboratory findings of the two groups. Results: The male to female ratio was 1.19. The most common systemic symptom was dizziness (7.6%), and the most common complication was rhabdomyolysis (23.6%). Distal bite sites (finger, toe) in group 1 occurred in 20 (35.7%) cases, and proximal (hand, foot, ankle, arm, calf, perianal area) in 36 (64.3%) cases (p<0.05). The median interval from envenomation to hospital visit was 6.0 (0.3- 96.0) h in group 1, which was longer than group 2 (p<0.05). Among 33 (19.5%) patients with local effect scores of 9~16, 25 (75.8%) patients had systemic symptoms and complications. The local effect scores and the interval from bite to antivenin treatment in the hospital were significant risk factors for systemic symptoms and complications in logistic regression analysis. Conclusion: Snakebite poisoning is an emergency and we must evaluate risk factors to prevent the development of serious complications.

Structural Changes of Zona Pellucida Surface of Immature, In vivo and In vitro Matured Canine Oocytes Using Scanning Electron Microscopy

최병현,Ayman Mesalam,송석환,주명돈,황지윤,오선화,이경림,공일근 사단법인 한국동물생명공학회 2018 한국동물생명공학회지 Vol.33 No.4

Zona pellucida (ZP), a primarily representative coat of mammalian egg and embryo, has an extremely heterogeneous morphology during different developmental stages. The objective of the present study was to compare the morphological changes of the ZP surface of immature, in vitro and in vivo matured canine oocytes by using scanning electron microscopy (SEM). Canine ovaries were collected from local veterinary hospitals to recover immature oocytes. The ovaries were sliced and the released cumulus oocyte complexes (COCs) were washed with TL-HEPES. The selected COCs were randomly divided into two groups, first group was processed immediately at immature state and the second group was processed 72 h after in vitro maturation, and compared with in vivo derived oocytes. Oocytes were fixed, critical point dried and examined under SEM. The diameters of oocyte and outer holes of the ZP were measured on a total of 249 oocytes; the results were analyzed using One-way ANOVA. Our results showed that, the diameter of immature oocytes significantly differed (p < 0.05) from that of in vivo matured oocytes (79.60 ± 0.77 μm vs. 101.46 ± 1.07 μm, respectively). Similarly, a significant difference (p < 0.05) in the diameters between those of in vitro and in vivo matured oocytes were found (79.51 ± 2.36 μm vs. 101.46 ± 1.07 μm, respectively). Moreover, the diameters of the outer holes of the ZP were significantly (p < 0.05) larger in in vivo matured (1.48 ± 0.42 μm) than in vitro matured for 72 and immature oocytes (1.10 ± 0.16 and 0.43 ± 0.12 μm, respectively). Taken together, these data indicates that the ZP surface is related to oocyte maturity in canine.