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천식 의심환자에서 기도과민성과 관련된 공기 매개성 알레르겐
한의령 ( Eui Ryoung Han ),최인선 ( Inseon S. Choi ),이석 ( Seok Lee ),조영욱 ( Yeong Wook Cho ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.2
Background: House dust mites and cats are major allergens causing asthma, and grass pollens are more closely related to allergic rhinitis. Objective: To investigate which aeroallergens are related to airway hyperresponsiveness (AHR), a characteristic feature of asthma, in Korean patients. Method: Medical records of suspected asthmatics, who performed both skin prick tests using common aeroallergens and the methacholine bronchoprovocation test between 2001 and 2007, were reviewed. A positive response to an allergen was defined as allergen/histamine wheal ratio of ≥1. A positive and a ≥moderate AHR were defined as 20% fall in FEV1 to ≤25 and ≤2 mg/mL of methacholine, respectively. The relative risks (adjusted odds ratio) for AHR compared to non-atopy were determined by a multivariate logistic regression analysis. Result: House dust mites were the most prevalent allergens in both asthma (n=238) and non-asthma (n=149) patients. The AHR severity was significantly related to the sensitization rates to house dust mites in asthmatics. The relative risks for ≥moderate AHR of subjects sensitized to Dermato-phagoides farinae and hazel were 1.21 (P<0.01) and 0.72 (P<0.05), respectively. Conclusion: Sensitization to a house dust mite, D. farinae, might be a significant risk factor for AHR, but hazel sensitization was protective and might be related to allergic rhinitis. (Korean J Asthma Allergy Clin Immunol 2007;27:105-110)