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Lee, J.-J.,Hahm, E.-T.,Min, B.-I.,Han, S.-H.,Cho, J.-J.,Cho, Y.-W. WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
The periaqueductal gray (PAC) is the main target site of the opioid-induced analgesia. The present study was designed to examine the roles of protein kinase A (PKA) and C (PKA) in the opioid-induced modulation of the currents activated by an inhibitory neurotiansmittei, y-aminobutyric acid (CABA). The PAG neurons were acutely isolated and voltage-clamped under the nystatin-perforated patch-clamp mode. The GABA-activated current was sensitively blocked by a GABA_(A) receptor antagonist, bicuculline, and selectively carried by chloride ions. The GABA_(A) receptor-activated Cl^(-) current was potentiated by a μ-opioid receptor agonist, [D-Ala^(2)N-MePhe^(4)Gly^(4)-ol]-enkephalin acetate (DAMGO). The GABA response was also potentiated by phorbol-12-myristate-13-acetate (PMA). Pretreatment with PMA occluded the DAMGO potentiation. However, both chelerythrine and 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide (GF109203X) also potentiated the GABA response. Pretreatment with chelerythrine of GF109203X also occluded the DAMGO potentiation. Meanwhile, the GABA response was potentiated by N-(2-[p-bromocinnamylamino]-ethyl)-5-isoquinolincsulfonamidc(H-89), while not altered by forskolin. Pretreatment with H-89 occluded the potentiation effect of DAMGO on the GABA response. In addition, the DAMGO effect was completely blocked by pretreatment with forskolin. From the result, it can be suggested that activation of μ-opioid receptor potentiates the GABA_(A) response through the mediation of PKA inhibition and PKC is not directly involved in the action mechanism of DAMGO.
Uom, E. S.,Min, B. I.,Kim, J. H.,Cho, Y. W. 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
The method of quick insertion and withdrawal of the needle (QIW) in acupuncture is a technique of stimulation not retaining the needle in the acupuncture point. We examined the analgesic effects of five different types of QIW along with the changes of stimulation quantity, time, and depth, and then compared the analgesic effect of the most effective QIW to that of plain acupuncture (PA). When tail-flick latency values between the strongest QIW-1 group and PA group were compared, there was no significant difference (analyzed by t-test). These results indicate that QIW technique has an analgesic effect similar to PA technique and that the conditions, which for the QIW-1 was shown the most effective analgesia, are a duration of 5 s at intervals of 1 s and at the depth of 3 mm.ⓒ 2001 Elsevier Science lreland Ltd. All rights reserved.
Choi, G.S.,Oh, S.D.,Han, J.B.,Bae, H.S.,Cho, Y.W.,Yun, Y.S.,Lee, W.K.,Ahn, H.J.,Min, B.I. WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
Electroacupuncture (EA) has been reported to modulate natural killer cell (NK cell) activities. Also it is well known that hypothalamus directly mediates the effects of EA on analgesia. Especially lateral hypothalamic area (LHA) is related to splenic NK cell activities. In order to investigate the relationship between hypothalamus and effects of EA on NK cell activity, lesions have been made bilaterally at LHA of Spraque-Dawley rats. Subsequently, NK cell cytotoxities of normal and lesioned rats were measured with ^51Cr release immunoassay after EA stimulation for 2 and 14 days. NK cell activity of EA group was significantly higher than sham group. In addition, lesions abolished effects of EA on NK cell activity. These results strongly suggest that LHA is closely related to increase of NK cell activity induced by EA. ⓒ 2002 Elsevier Science lreland Ltd. All rights reserved.