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효율적인 Keyword Spotting을 위한 Open-Set Error 기반 CNN 학습 기법
조영섭(Young-Sub Jo),윤치원(Chi-Won Yun),이창림(Chang-Lin Li),황정현(Jung-Hyun Hwang) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.11
The convolutional neural networks have been implemented and demonstrated on embedded devices for keyword spotting applications. In this paper, an open-set error based convolutional neural networks learning method is proposed for efficient keyword spotting. The pre-processing and training method to convert speech data to neural network data is also proposed. The experimental results by implementing in embedded SoC Products and GPU show that the proposed method achieves higher accuracy than conventional method.
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[123I]Idoxifene 합성과 유방암의 세포섭취에 관한 연구
임수정,임상무,양승대,서용섭,전권수,안순혁,유국현,조영섭 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.5
Purpose: Idoxifene is currently entering phase Ⅱ clinical trials for the treatment of advanced breast cancer. The radiolabeled idoxifene using 123I provides an opportunity for clinical pharmacology with single photon emission computed tomography (SPECT). The purpose of this study was to prepare radiolabeled idoxifene using 123I and to determine its cell uptake of breast cancer cell line. Materials and Methods: With a view to evaluating new anticancer drugs, we are investigating the novel antiestrogen pyrrolidino- 4-iodotamoxifen (idoxifene). [123I]Idoxifene has been prepared in no-carrier-added form using a tributyl stannylated precursor which has been synthesized by means of (2-chloroethoxy)benzene with (±)-2- phenylbutanoic acid on the basis of previously reported standard methods. The biodistribution and dynamic behavior of the compound were investigated using the comparative breast cancer cell line, MCF-7 (estrogen receptor-positive) and MDA-MB-468 (non-estrogen receptor). Results and Conclusion: Acylatn of (2-chloroethoxy)benzene with (±)-2-phenylbutanoic acid gave the versatile ketone (81%) which reacted with 1,4-diiodobenzene to give triphenylethylene as a mixture of E and Z geometric isomers, which were separated by the recrystallization in ethanol. The E-isomer was treated with pyrrolidine to give idoxifene (67%). In order to incorporate radioactive iodine into the 4-position, the 4-stannylated precursor was prepared (30%). The yield of radioiodination was 90-92% with a high radiochemical purity greater than 98%. The ratio of tumor uptake of the breast cancer cell line between MCF-7 and MDA-MB-468 was about 1.7.
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