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전이성 대장암 환자에서 Oxaliplatin 반응군과 비반응군과의 비교
조민미,배옥석,백성규,이태순,박성대 대한대장항문학회 2006 Annals of Coloproctolgy Vol.22 No.6
Purpose: The purpose of this study was to evaluate the clinicopathological significance of responders with metastatic colorectal cancer treated with oxaliplatin chemotherapy. Methods: A total of 52 patients with unresectable metastatic colorectal cancer were enrolled for treatment between March 2000 and August 2005. Patients received first line chemotherapy consisted of oxaliplatin 85 mg/m2 or 130 mg/m2 as a 2-hour infusion on day 1, concurrently with leucovorin (LV) 20 mg/m2 as a bolus infusion on day 1~5, followed by continuous infusion of 5-fluorouracil (5-FU) 425 mg/m2 on day 1~5. This treatment was repeated in 2 or 3 week intervals. All responses were assessed after 4 cycles of therapy by independent radiologic experts and categorized into two groups: responder (major reduction of tumor) and non-responder group (no change or progression of the tumor. Results: The response rate was 51.9 percent (27/52 patients). There were no significant differences in clinicopathologic parameters between two groups. The decrease of CEA value after chemotherapy was significantly more frequent in the responder group than in the non-responder group. Conclusions: We could not find any clinical differences between the two groups, but these results suggest that oxaliplatin chemotherapy has a beneficial effect on tumor shrinkage and serum CEA value can be an indicator for tumor response of oxaliplatin in advanced colorectal cancer.
An efficient synthetic protocol for amide derivatives of Boc-2- aminoisobutyrate
조민미,원선우,이동국,정재경,김선홍,곽영신 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.3
Aminoisobutyric acid (AIB) is an importantbuilding block widely incorporated by medicinal chemistsin molecular design. Owing to the steric challenge, elaboratingAIB’s carboxylic acid using conventional amidationprotocols is often problematic. We discovered that anamidation protocol utilizing methyl Boc-aminoisobutyrateand magnesium amidates of various reactivities producesthe corresponding amide derivatives in good to excellentyields.
Facile ring opening reaction of oxazolone enables efficient amidation for aminoisobutyric acid
조민미,원선우,이동국,윤정연,김선홍,곽영신 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.5
4,4-Dimethyloxazolones derived from N-protectedaminoisobutyric acid (AIB) are particularly knownas poor electrophiles due to the steric hindrance around thecarbonyl and not employed as useful intermediates foramidation whereas numerous examples have been reportedto support the utility of other oxazolones in amidation. AIBis an important and strategical synthon in medicinalchemistry but the peptide bond formation of the N-protectedurethane derivatives of AIB is known to be oftenunproductive due to the rapid formation of the stable 4,4-dimethyloxazolone via an intramolecular cyclization. Wediscovered that the 4,4-dimethyloxazolone of an AIB urethaneis in fact an excellent electrophile that enables efficientamidation even with weakly reactive nucleophiles. The 4,4-dimethyloxazolone can be stored in a pure formand used as a reagent offering an efficient and convenientsynthetic tool for generating AIB-peptide analogs.
염창호,조민미,백성규,배옥석 대한대장항문학회 2010 Annals of Coloproctolgy Vol.26 No.5
Purpose: Clostridium difficile (C. difficile)-associated colitis, a known complication of colon and rectal surgery, can increase perioperative morbidity and mortality, leading to increased hospital stay and costs. Several contributing factors, including advanced age, mechanical bowel preparation, and antibiotics, have been implicated in this condition. The purpose of this study was to determine the clinical features of and factors responsible for C. difficile-associated colitis after colorectal cancer surgery. Methods: The medical records of patients who had undergone elective resection for colorectal cancer from January 2008 to April 2010 were reviewed. Cases that involved procedures such as transanal excision, stoma creation, or emergency operation were excluded from the analysis. Results: Resection with primary anastomosis was performed in 219 patients with colorectal cancer. The rate of postoperative C. difficile-associated colitis was 6.8% in the entire study population. Preoperative metallic stent insertion (P = 0.017)and aged sixty and older (≥ 60, P = 0.025) were identified as risk factors for postoperative C. difficile-associated colitis. There were no significant differences in variables such as preoperative oral non-absorbable antibiotics, site of operation, operation procedure, and duration of prophylactic antibiotics. Conclusion: Among the potential causative factors of postoperative C. difficile-associated colitis, preoperative metallic stent insertion and aged sixty and older were identified as risk factors on the basis of our data. Strategies to prevent C. difficile infection should be carried out in patients who have undergone preoperative insertion of a metallic stent and are aged sixty and older years.