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간염과 간경변증 환자에 있어서 간염 B 바이러스의 혈청학적 표식자들에 관한 연구
이석희(Seok Hee Lee),조규찬(Kyu Chan Jo),이승모(Han Kyu Moon),문한규(Seung Mo Lee) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1
N/A The author carried out study to determine serological markers of hepatitis B virus (HBV) and the activity of aminotransferase and alkaline phosphatase and serum total bilirubin in 120 cases of acute viral hepatitis(AVH), in 32 cases of chronic active hepatitis(CAH) and in 43 cases of liver cirrhosis in Pusan National University Hospital and several hospitals in Pusan area during the period from March, 1982 to August, 1983. Diagnoses were clinically or pathologically confirmed in all the patients. Serological HBV marker were determined by radioimmunoassay. Serum aminotansferase and alkaline phosphatase activities were measured by Reitman Frankel and King-King methods respectively. The serum total bilirubin was measured by Jendrasik-Grof method. The results obtained were summarized as follows: 1) 90.8% of acute viral hepatitis, 96.9% of acute viral hepatitis, 96.9% of chronic active hepatitis and 9.7% of liver cirrhosis had the serological evidences of either a current of past infectien with HBV. 2) In AVH, CAH and liver cirrhosis, positive rate of ant-HBC of 5 serological HBV markers was the most common and that of HBsAg was the next. 3) In AVH, CAH and liver cirrhosis, the positive rate of HBeAg was tended to be higher than that of anti-HBe. 4) In AVH, CAH and liver cirrhosis, the pattern III (HBsAg+, HBeAg+, anti-HBc+) of serological HBV markers was the most common and the pattern VII(anti-HBc+) was the next. 5) The activities of aminotransferase and alkaline phosphatase and the level of serum total bilirubin were higher in the pattern I, II, III, VI and VII than those in the pattern VI and VIII in AVH. 6) The activitv of serum aminotransferase was tended to be higher in HBeAg positive cases of chronic active hepatitis than that in anti-HBe positive ones. 7) In the liver cirrhosis, no correlation of serological HBV markers to the results of some liver function tests was found. On the basis of these finings, it was suggested that HBV might play an important role in causation in most cases of acute and chronic hepatitis and liver cirrhosis in Korea.