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한국인 수혈후 간염과 만성 간질환 환자에서의 C형 간염바이러스 감염동태 (제1보)
정규원 ( Jeong Gyu Won ),선희식 ( Seon Hui Sig ),정환국 ( Jeong Hwan Gug ),신호균 ( Sin Ho Gyun ),박충기 ( Park Chung Gi ),유재영 ( Yu Jae Yeong ),( Adrian M. Di Bisceglie ),( Jeanne J. Waggoner ),( Jay H. Hoofnagle ) 대한내과학회 1990 대한내과학회지 Vol.38 No.6
N/A To investigate the prevalence of antibodies to hepatitis C virus infection in patients with various chronic liver diseases in Korea, we tested 240 serum samples using the Abbott enzyme immunoassay method. The result sare summarized as follows: 1) Among 57 patients with post-transfusion hepatitis(PTH), 38(66.7%) were positive for anti-HCV. Four out of 57 patients were also positive for HBsAg, of which three were positive for anti-HCV. 2) In 131 patients with chronic non-A, non-B hepatitis, who had no history of blood transfusions, 60(45.8%) were positive for anti-HCV; of them 42 out of 85(49.4%) patients with chronic hepatitis, 14 out of 34(41.2%) with liver cirrhosis, and four out of 12(33.3%) with fatty liver and alcoholic hepatitis were positive for anti-HCV. 3) In 27 patients with HBsAg negative hepatocellular carcinoma, 13(48.1%) were positive for anti-HCV. 4) In 25 patients with chronic hepatitis B, who were negative for HBeAg but had active liver disease by liver biopsy, two(8%) were positive for anti-HCV. In conclusion, the prevalence of type C hepatitis in Korea was similar to that of other countries. This test is useful in confirming the diagnosis of various chronic viral hepatitis patients in Korea. Meanwhile, studies of larger numbers of patients and blood donors are necessary to estimate the exact prevalence of this type of hepatitis in Korea.