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반사된 국소화 표면 플라즈몬 공명 신호를 이용한 광섬유기반 바이오센서의 측정 신호처리 방법
이승기 ( Seung Ki Lee ),정현호 ( Hyeon Ho Jeong ) 한국센서학회 2011 센서학회지 Vol.20 No.2
LSPR(Localized Surface Plasmon Resonance) sensor measures the refractive index change on the sensor surface. The detection of biological reaction with the unknown refractive index needs to be converted into the signal sensitivity for the refractive index change for comparison with other measurements. To find the signal sensitivity, the three steps of signal processing are proposed, which are signal modeling, signal calibration and signal normalization of LSPR sensor. The detected signal of biotin-streptavidin interaction has been converted into unit of [RU](Resonance Unit) using the proposed method. The converted signal directly can be compared with the other sensors including commercialized one.