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정헌정,이혜원,박대섭 동아시아경상학회 2017 The East Asian Journal of Business Economics Vol.5 No.4
The purpose of this study is to identify the structural influencing relationship of a hotel chief’s competency, job satisfaction and guest orientation. Moreover, this research tries to point out implication of effective human resource management, based on competency, to intensify job satisfaction and guest orientation, by verifying the influential relationship of job satisfaction between personal competency and guest orientation. To achieve those goals, as a result of substantiation analysis, a hotel chief’s personal competency, such as self-control, guest orientation, situation management and professionalism, has a positive impact on job satisfaction. However, it turned out that situation management has no positive influence on guest orientation. Lastly, the analysis indicated that organization concentration has control effect on job satisfaction and guest orientation.
조현병 환자에게서 RORA 유전자 다형성과 항정신병 약물과 관련된 하지불안증후군의 연관성
정진숙,조철현,윤호경,강승걸,박영민,이헌정,김린 대한조현병학회 2013 대한조현병학회지 Vol.16 No.2
Objectives : The previous studies have suggested genetic vulnerability to restless legs syndrome (RLS) development. The occurrence of antipsychotic-related RLS could also be attributable to differences in genetic susceptibility. This study aimed to investigate whether Retinoid-related orphan receptor A (RORA) gene polymorphism is associated with antipsychotic-related RLS in schizophrenia. Methods : We assessed symptoms of antipsychotic-induced RLS in 190 Korean schizophrenic patients and divided the subjects into two groups according to the International Restless Legs Syndrome Study Group diagnostic criteria : 1) subjects that met all of the criteria (n=44) and 2) the remaining subjects who were not considered to be RLS patients (n=146). Single-nucleotide polymorphism in the RORA gene was genotyped by PCR in 190 individuals. The χ2-test was conducted to compare differences between two groups. Results : The frequencies of genotype (χ2=0.066, p=0.968) of the RORA gene (rs11071547) did not differ significantly between schizophrenic patients with and without RLS. The difference of allele frequencies (χ2=0.008, p=0.927) of the RORA gene (rs 11071547) between the schizophrenic patients with and without RLS were not significant. Conclusion : These results suggest that RORA gene polymorphism does not play a major role in susceptibility to antipsychotic-related RLS in schizophrenia. RLS는 강한 유전성을 보이는 질환이며 증상이 주기적으로 발현되는 데 생체시계가 연관이 있다고 알려져 있다. 하루주기리듬을 만들어내는 데 중요한 전사인자인 RORA가 RLS의 발생 취약성에 있어서 좋은 후보 유전자가 될 수 있겠다. 본 연구에서는 RORA 유전자의 다형성과 항정신병 약물과 연관된 RLS의 관계를 살펴보고자 190명(44명의 RLS, 146명의 non-RLS)의 조현병 환자들을 대상으로 연구하였다. 결론적으로 RORA 유전자 다형성과 항정신병약제와 관련된 RLS의 연관성을 발견하지 못하였다. 그러나 본 연구는 RORA 유전자 다형성과 항정신병약물과 관련된 RLS의 연관성을 살펴본 연구로 의의가 있으며 향후 RLS와 다른 생체시계와 연관된 추가적인 후보 유전자들에 대한 연구가 진행된다면 RLS의 유전학적 병태생리를 이해하는데 큰 도움이 될 것이다.