4세 여아의 거대 선천멜라닌세포모반에서 발생한 악성흑색종

전재헌 ( Jae Hun Jun ),정한진 ( Han Jin Jung ),이석종 ( Seok Jong Lee ),이원주 ( Weon Ju Lee ),김도원 ( Do Won Kim ),박진영 ( Jin Young Park ),김명화 ( Myung Hwa Kim ),박병철 ( Byung Cheol Park ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.12

Melanoma may arise from a very giant congenital melanocytic nevus even in the first several years of life. Therefore, excision of a giant congenital melanocytic nevus should be considered as early as possible. However considering surgical and anesthetic risks, the surgery can wait until after the first 6 months of life. Unfortunately, surgical treatment does not completely prevent occurrence of melanoma from a giant congenital melanocytic nevus. Besides, several cases of melanoma occurring after blunt trauma or laser therapy have been reported. We report a case of malignant melanoma associated with a giant congenital melanocytic nevus in a 4-year-old female. The malignant melanoma occurred at the boundaries of the previous surgical excision and laser therapy sites for a giant congenital melanocytic nevus. This is the youngest case of malignant melanoma developed from a congenital melanocytic nevus in the Korean dermatological literature. (Korean J Dermatol 2011;49(12):1102~1106)

피부상처 또는 수술부 결손에서 Maggot을 이용한 생물학적 치료

전재헌 ( Jae Hun Jun ),정한진 ( Han Jin Jung ),임현정 ( Hyun Jung Lim ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.10

Background: Maggots are larva of Phaenicia Sericata, the Green Blowfly, and treatments with maggot have recently become widespread revealing their effectiveness in the treatment of chronic wounds, such as diabetic ulcers and pressure sores, by removing necrotic tissue selectively and avoiding damage of healthy tissue. Objective: The aim of this study was to evaluate the usefulness and the adverse effects of maggot therapy in dermatology for the treatment of chronic wounds and rapid granulation tissue formation at postoperative defects before reconstruction. Methods: Fourteen patients with various kinds of skin wounds were included and applied a biobag containing therapeutic maggots on their wounds. Results: Four cases were included for treatment of acute and chronic skin wounds; 10 cases of surgical defects were included for reduction of the treatment period. Maggot therapy periods ranged from 4 to 17 days (mean: 8.3 days). Complete elimination of necrotic tissue was achieved in 7 cases (50%) and partial elimination was achieved in 7 cases (50%). There weren`t any cases of incomplete elimination or no response. Eight cases (57.1%) were in the ``excellent`` group which had shown rapid granulation tissue formation and 3 cases (21.4%) were in the ``good`` group, which had shown relatively rapid granulation tissue formation. But, there were 3 cases (21.4%) which had shown no difference from the previous time. Acute complications such as pain and bleeding had occurred in a few cases after maggot therapy. Conclusion: We suggest that the maggot therapy is a useful and effective method to use in the field of dermatology. (Korean J Dermatol 2011;49(10):901∼906)

수치에 따른 숙지황 중의 5-hydroxymethyl-2-furaldehyde 함량분석

황석연,황방연,최우희,정한진,허재두,이경순,노재섭,Hwang, Suk-Yeon,Hwang, Bang-Yeon,Choi, Woo-Hoi,Jung, Han-Jin,Huh, Jae-Doo,Lee, Kyong-Soon,Ro, Jai-Seup 한국생약학회 2001 생약학회지 Vol.32 No.2

In order to determine the content of 5-hydroxymethyl-2-furaldehyde (5-HMF) in the Rehmanniae Radix Preparata, 5-HMF was isolated from the EtOAc fraction of the Rehmanniae Radix Preparata samples and identified by spectroscopic and physicochemical evidences. Twenty one samples prepared on the basis of increasing number of stewing times with wine were analyzed by HPLC. From this analysis, it was revealed that the samples processed under one to nine times of stewing showed increasing pattern in 5-HMF contents. And the samples processed under 9 to 18 times of stewing showed 0.53-0.74% in 5-HMF contents. However, for those samples processed more than 19 times, 5-HMF content profile showed decreasing pattern.

Cohort Infant Mortality Rate of Gunwee and Hapchun Counties and an MCH Center in Taegu

박정한,예민해,천병렬,송정흡,김귀연,김장락,조성억,김현,정한진,조재연,Park, Jung-Han,Yeh, Min-Hae,Chun, Byung-Yeol,Song, Jung-Hub,Kim, Gui-Yeon,Kim, Jang-Rak,Cho, Sung-Euk,Kim, Hyun,Chung, Han-Jin,Cho, Jae-Yeon The Korean Society for Preventive Medicine 1990 예방의학회지 Vol.23 No.1

1985년 4월 1일부터 1987년 3월 31일 사이에 경상북도 군위군에 거주하는 49세이하의 가임여성들과 1987년 3월 1일부터 1988년 2월 28일 사이에 경상남도 합천군에 거주하는 49세이하의 가임여성들 그리고 1985년 4월 1일부터 1987년 3월 31일 사이에 대구시 남구 모자보건센터에 분만을 위해 찾아온 모든 임산부들을 대상으로 이들에게서 태어난 출생아들을 두 군지역에서는 생후 1년간 그리고 모자보건센터에서 출생한 경우는 생후 27일간 추적하여 영아사망률과 신생아 사망률을 각각 조사하였다. 조사기간중에 군위군과 합천군에서 출생한 1,359명의 영아들 가운데 생후 1년 동안에 17명이 사망하여 농촌지역의 영아사망률은 출생아 1,000명당 12.5이었다. 총 영아사망중 신생아사망이 82.4% 그리고 신생아 후기 사망이 17.6%를 차지하였다. 대구시 남구 모자보건센터에 내원한 산모들에게 태어난 6,001명의 출생아들 가운데 4,834명(80.6%)만이 생후 27일까지 추적되었는데 이들 중 36명이 사망하여 신생아 사망률은 출생아 1,000명당 7,4명이었다. 추적된 산모와 추적 안된 산모의 특성 및 신생아 체중을 비교한 결과 현저한 차이를 나타내지 않았다. 신생아 후기 사망률의 비를 6 : 4로 가정했을 때 모자보건센터에서 출생한 영아의 영아사망률은 출생아 1,000명당 12.3명으로 추정되었다. 군위군과 합천군의 영아사망률과 대구시 남구 모자보건센터에서 관찰된 신생아사망률, 영아사망의 사망시기별 분포와 영아사망원인 그리고 저체중아출생률을 고려할 때 1985년부터 1988년 사이의 한국의 영아사망률은 출생아 1,000명당 12에서 15명일 것으로 추정되었다. We followed up all the infants born to the married women under 50 years of age residing in Gunwee county, Kyungpook Province, between 1 April 1985 and 31 March 1987, and those born to the married women under 50 years residing in Hapchun County, Kyungnam Province, between 1 March 1987 and 28 February 1988, to their first birthday. Likewise, we followed up the infants born to the women who visited the MCH Center of South District Health Center in Taegu City for delivery between 1 April 1985 and 31 March 1987 to the 27th day after birth and obtained the infant mortality rate and the neonatal mortality rate, respectively. There were 17 infant deaths among 1,359 live births in Gunwee and Hapchun Counties and the infant mortality rate was 12.5 per 1,000 live births. Out of 17 infant deaths, 82.4 percent were neontal death and 17.6 percent were postnonatal deaths. Out of the 6,001 live births born to the women visited the MCH Center, 4,834 infants (80.6%) were followed up to the 27th day after birth. Of these 4,834 infants, 36 infants died before the 28th day after birth and thus the neonatal mortality rate was 7.4 per 1,000 live births. Comparison of the maternal characteristics and the birth weight between infants who were followed up and those who were lost to follow-up showed no significant differences. Assuming that the neonatal and postneounatal mortality ratio had been 6:4, the infant mortality rate for the infants born at the MCH Center would have been 12.3 per 1,000 live births. Taking such findings into consideration as the infant mortality rate observed in Gunwee and Hapchun Counties, the neonatal mortality rate at the MCH Center, the causes of infant deaths, and the low birth weight incidence rate, a conservative estimate of infant mortality rate of Korea would be between 12 and 15 per 1,000 live births in $1985{\sim}1988$.

유치원시설의 원시규모와 보육실, 유희실의 특징분석 : 제주시 유치원의 사례 분석 case study of a preschool in jeju city

김한진,김태일,박철민,정별아 대한건축학회 2001 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.21 No.1

Preschool have been increasing Recently with an early education and mitigation of establishment. In case of Jeju city, there are 30 present of all preschool of Jeju-do and 45 percent of all classroom are concentrated in Jeju city. Though various preschool, like, pace using by remodeling of existed elementary classroom are increasing, it is not many about research and analysis of the present condition of preschool, especially about of an analysis of building scale and nursery room and playing room. This study is focused on an analysis of building scale and nursery room and playing room and all preschaal in Jeju city. This study is consisted of two steps. 1n first step, it was measured of plan anrt understand scale, plan type and so on. In second step, it was a question research to the management of preschool. A result of analysis are as following; 1. Most of preschool under 300 are complex with other facilities like church and elementary, and so on and its ail are public preschool. 2. In case of public preschool, many of preschool are under proper scale and especially nursery room are under proper scale. 3. And playing property of planning of playing roam are no good than its of nursery room.