항암화학요법에서 발생하는 소화기 부작용의 관리

정진태,Jin Tae Jung 대한소화기암연구학회 2015 Journal of digestive cancer reports Vol.3 No.2

Gastrointestinal side effects including nausea and vomiting, diarrhea, constipation, oral mucositis and colitis, and hepatotoxicity are common occurrence during chemotherapy. Often they result in unplanned admission and interruption of scheduled therapy. Additionally they have a negative influence on patient's therapeutic outcome and quality of life. The assessment of gastrointestinal side effects is dependent on clinician assignment of a grade established by the National Cancer Institute Common Terminology Criteria for Adverse Events. Continued interest of gastrointestinal side effects has allowed identifying patients at higher risk and providing effective treatments to relieve painful symptom. Finally, proper prevention and management of chemotherapy-induced gastrointestinal side effects will be needed to improve patient's survival and quality of life.

KTX 2차 구동장치에 대한 예방정비 비용의 최적화에 관한 연구

정진태(Jung, Jin-Tae),김철수(Kim, Chul-Soo) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.2

차축 감속기와 차륜으로 구성된 고속철도차량 2차 구동장치는 일체형 조립체이지만, 상이한 기술사양으로 인하여 이들의 예방정비 주기는 서로 다르다. 특히, 이들은 완전분해 정비주기에 따라 매번 동시에 탈부착 작업을 수행한다. 따라서 불필요한 완전분해 정비를 감소하고 높은 열차 가용도를 유지하기 위해서는 신뢰성 중심 유지보수 관점에서 예방정비 비용 의 최적화가 중요하다. 본 연구에서는 실제 정비이력으로부터 두 구성품들에 대한 결함나무 분석을 수행하고, 각 하부부품들 의 치명도를 고려한 수정된 신뢰도를 각각 평가하였다. 두 구성품에 대한 예방 정비비용의 최적화는 기준 신뢰도 및 개선율 을 고려한 유전자 알고리즘으로부터 구하였다. 비용의 최적화는 개체의 적합도 함수에 대한 최대값으로부터 얻는다. 유전자 알고리즘에 의한 최적의 완전분해 정비주기는 285만km로서, 기존 방법의 총비용과 비교하여 약 21% 감소하였다. Although the second driving device of KTX, which consists of the wheel and the axle reduction gears unit, is a mechanically integrated structure, its preventive maintenance (PM) requires two separate intervals due to the different technical requirements. In particular, these subsystems perform attaching and detaching work simultaneously according to the maintenance directive. Therefore, to reduce the unnecessary amount of PM and high logistic availability of the train, it is important to optimize PM with regard to reliability-centered maintenance toward a cost-effective solution. In this study, fault tree analysis and reliability of the subsystems, considering the criticality of the components, were performed using the data derived from field data in maintenance. The cost optimization of the PM was derived from a genetic algorithm considering the target reliability and improvement factor. The cost optimization was derived from a maximum of the fitness function of the individual in generation. The optimal TBO of them using the genetic algorithm was 2.85x106 km, which is reduced to approximately 21% compared to the conventional method.

위 점막연관림프조직 림프종: 국내 치료 성적을 중심으로

정진태 ( Jin Tae Jung ) 대한소화기학회 2016 대한소화기학회지 Vol.68 No.4

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is associated with Helicobacter pylori infection. H. pylori eradication can be performed as a primary therapy regardless of H. pylori status. In Korea, six articles were published about low-grade gastric MALT lymphoma with H. pylori. Complete regression rate after H. pylori eradication is reported at 74.5% to 94.4%. Radiotherapy results in favorable clinical long-term outcomes in patients with early-stage gastric MALT lymphoma who fail H. pylori eradication therapy and those who are H. pylori negative. Chemotherapy could be reserved for patients with metastatic or high-grade lymphoma. In gastric MALT lymphoma, patients with polypoid type on initial endoscopy had a higher likelihood of recurrence than those with diffuse infiltration or ulceration types. The depth of invasion, location of lesions, and chromosomal abnormality with t(11;18) together are predictive factors for failure to remission by H. pylori eradication. (Korean J Gastroenterol 2016;68:175-178)

상피하 종양 형태로 나타난 심재성 낭성 위염

정진태 ( Jin Tae Jung ) 대한소화기학회 2016 대한소화기학회지 Vol.68 No.6

고속철도차량 동력전달장치의 예방정비주기 평가

정진태(J. T. Jung),김철수(C. S. Kim) 한국산학기술학회 2015 한국산학기술학회 학술대회 Vol.2015 No.1

철도차량의 총 수명주기 비용은 운용/유지 비용이 약 70%를 차지하고 있으며, 이 비용중에서 시스템의 정상가동에 따른 가용도 유지를 위한 정비비용이 큰 비중을 차지한다. 본 연구에서는 상호 연결된 2개 조립체이지만 완전분해 정비주기가 이 논문에서는 유전자 알고리즘을 이용하여 고속차량의 주요구성품인 동력전달장치의 최적 예방유지보수 주기산정에 대하여 연구하고자 한다.

고속차량 중련운행시 가선과 집전장치 인터페이스 고찰

정진태(Jin-Tae Jung),박찬경(Chan-Kyoung Park) 대한전기학회 2013 대한전기학회 학술대회 논문집 Vol.2013 No.10

종양조직에 항암제 전달을 강화하기 위한 고강도 초음파 집적술의 역할

정진태 ( Jin Tae Jung ),이돈행 ( Don Haeng Lee ),황주하 ( Joo Ha Hwang ) 대한소화기학회 2009 대한소화기학회지 Vol.53 No.4

Cancer is the first leading cause of death in Korea. Systemic chemotherapy is currently the standard treatment for a wide variety of cancers; however, in the majority of cases, cure is not achieved, and the attendant side effects of the treatment are considerable. The effectiveness of chemotherapy in cancers depends on the adequate delivery of the chemotherapeutic agent to cancer cells. The achievement of uniform drug delivery of chemotherapeutic agents throughout tumors is limited by the anomalous vascularization and blood vessel permeability. Ultrasound has an ever-increasing role in the delivery of therapeutic agents including chemotherapeutic agents, proteins, and genetic materials. Ultrasound technology allows for the use of focused ultrasound energy for therapeutic purposes by delivering high-intensity focused ultrasound for applications such as tissue ablation, and enhanced drug delivery. We reviewed recent work in the emerging field of ultrasound-based therapeutics, with particular emphasis on the delivery of drugs to tumor tissue. (Korean J Gastroenterol 2009;53:216-220)

당뇨를 동반한 4기 대장암 환자에서 항암약물요법에 Metformin의 병용치료는 효과가 있는가?

정진태 ( Jin Tae Jung ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.6

고속철도차량 1차 구동장치에 대한 완전분해정비의 최적 주기 평가

정진태(Jung, Jin-Tae),김철수(Kim, Chul-Soo) 한국산학기술학회 2015 한국산학기술학회논문지 Vol.16 No.12

고속철도차량 동력대차의 1차 구동장치는 모터 감속기와 견인전동기로 구성한다. 모터 감속기와 견인전동기는 기계 적으로 일체형 결합 구조이지만, 상이한 기술 요구사항으로 인하여 이들의 완전 분해정비 주기는 서로 다르다(모터 감속기의 완전 분해정비 주기: 1.8x106 km, 견인전동기의 완전 분해정비 주기: 2.5x106 km). 따라서 불필요한 정비 횟수를 감소하기 위하여 신뢰성 중심 유지보수 관점에서 최적의 완전 분해정비 주기의 산정이 중요하다. 본 연구에서는 실제 유지보수 정비이 력으로부터 두 구성품들에 대한 고장 결함나무 분석을 수행하고 각 하부부품들의 치명도를 고려한 고장률을 각각 평가하였 다. 두 구성품에 대한 최적의 동일한 완전분해 정비주기는 기존의 총 예방정비 비용을 감소하기 위하여 유전자 알고리즘으로 부터 얻었다. 이 알고리즘에서 각 개체를 구성하는 유전자는 최소 예방 정비주기이며, 이의 조합으로 구성된 세대별 개체의 적합도함수는 총 정비비용의 역수로 공식화하여 얻는다. 최소공배수에 의한 방법은 기존 대비 4%만 감소하지만, 유전자 알 고리즘에 의한 최적의 동일 완전분해 정비주기는 225만km로서 기존 방법의 총비용과 비교하여 약 14% 감소하였다. The first driving device of the power bogies for the Korean high-speed railway vehicle consists of the traction motor (TM) and the motor reduction gears unit (MRU). Although TM and MRU are the mechanically integrated structures, their time between overhauls (TBO) have two separate intervals due to different technical requirements(i.e. TBO of MRU: 1.8x106km, TBO of TM: 2.5x106km). Therefore, to reduce the unnecessary number of preventive maintenances, it is important to evaluate the optimal TBO with a viewpoint of reliability-center maintenance towards cost-effective solution. In this study, derived from the field data in maintenance, fault tree analysis and failure rate of the subsystem considering criticality of the components are evaluated respectively. To minimize the conventional total maintenance cost, the same optimal TBO of the components is derived from genetic algorithm considering target reliability and improvement factor. In this algorithm, a chromosome which comprised of each individual is the minimum preventive maintenance interval. The fitness function of the individual in generation is acquired through the formulation using an inverse number of the total maintenance cost. Whereas the lowest common multiple method produces only a four percent reduction compared to what the existing method did, the optimal TBO of them using genetic algorithm is 2.25x106km, which is reduced to about 14% comparing the conventional method.

악성 담관 폐쇄 환자에서 흰 담즙의 임상 의의

정진태 ( Jin Tae Jung ),김호각 ( Ho Gak Kim ),한지민 ( Ji Min Han ),권중구 ( Joong Goo Kwon ),이창형 ( Chang Hyeong Lee ),김은영 ( Eun Young Kim ) 대한소화기학회 2008 대한소화기학회지 Vol.52 No.2

Background/Aims: White bile is colorless, translucent fluid found occasionally in malignant bile duct obstruction (MBO). Little information is available on the cause and effect of white bile. The aim of this study was to determine the frequency and clinical significance of white bile in MBO. Methods: Bile was aspirated during endoscopic retrograde cholangiopancreatography in consecutive patients with MBO. White bile was defined as bile bilirubin <1.5 mg/dL and yellow bile was defined as bile bilirubin ≥1.5 mg/dL in the bile. Two groups were compared prospectively for the duration of jaundice, itching, cholangitis, level of obstruction, and decremental rate of bilirubin after the insertion of 7 Fr endoscopic nasobiliary drainage until the insertion of metal stent or 10 Fr plastic stent. Results: Among 60 patients with MBO, 16 (26.7%) had white bile. WBC count in blood was higher (9,456/mm3 vs. 7,400/mm3, p=0.029) and cholangitis was more common (11/16 vs. 7/44, p=0.000) in white than yellow bile group. Proximal portion of MBO had no communication with GB in 9/16 patients with white bile group and 17/44 patients with yellow bile group (p>0.05). Mean survival of the inoperable 35 patients was 242 days in yellow bile and 227 days in white bile group (p>0.05). Conclusions: White bile in MBO was not rare and was associated with cholangitis. Gallbladder did not seem to play a role in the formation of white bile. Further study for the pathogenesis and prognosis of white bile in MBO will be necessary. (Korean J Gastroenterol 2008;52:91-96)