표준 치료를 받고 있는 제2형 당뇨병 환자에서 혈당강하제와 평위산 및 향사평위산 병용 투여가 혈당에 미치는 영향 및 안정성 연구

정우녕,오승현,송미령,노지원,안영민,안세영,이병철 대한한방내과학회 2023 大韓韓方內科學會誌 Vol.44 No.4

This retrospective study delved into the effects and safety considerations associated with the concomitant usage of hypoglycemic agents and herbal extracts, specifically Pyeongwi-san (PWS) or HyangsaPyongwi-san (HSPWS) in the context of type 2 diabetes mellitus management. Methods: The investigation involved 38 inpatients with type 2 diabetes mellitus who received PWS or HSPWS treatment at Kyung Hee University Korean Medical Hospital from January 2012 to December 2022. By investigating clinical attributes and conducting laboratory assessments, this study aimed to discern the impact of these herbal extracts on blood glucose levels, encompassing fasting blood sugar (FBS) and mean 2-hour postprandial glucose (PP2) levels. Furthermore, the safety profile of the herbal extracts was assessed by comparing liver function indicators, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (GGT), alongside kidney function markers, such as blood urea nitrogen (BUN) and creatinine (Cr). Results: Following the administration of the herbal extracts, no statistically significant alterations in FBS and mean PP2 levels emerged compared to the baseline levels. Notably, the safety evaluation revealed no significant differences in liver and kidney function parameters following herbal extract administration. Conclusion: The results of this research indicate that using PWS or HSPWS alongside hypoglycemic medications could be a beneficial additional method for addressing digestive symptoms in individuals with type 2 diabetes mellitus. Notably, this combination seems to have no negative interactions with other drugs.

모유수유 산모의 한의학적 치료에 대한 고찰

정우녕(Woo-Nyoung Jung) 대한모유수유한의학회 2021 nipple confusion,breastfeeding consultation,IBCLC, Vol.2 No.1

Objectives: The purpose of this study is to review safety of taking herbal medicines during breastfeeding and Korean medicine approach to problems that occur to mothers during breastfeeding. Methods: Literature search was done using database such as Pubmed, Google scholarship, RISS and Uptodate scholastic. Search words were ‘breastfeeding TCM’, ‘herbal medicine’, ‘Korean medicine’ and ‘safety’. Only English and Korean studies were assessed. Results: For most single herbs used in Korean medicine, there were few studies on the safety during lactation, and the reported studies show conflicting results. In terms of herbal medicine decoctions, there were several studies reporting of no side effects when taken by breastfeeding mothers. Meanwhile, Korean medicine can be used for problems arising from breastfeeding such as insufficient milk supply, laceration of nipples, pain, and mastitis. Conclusions: Although clinical studies reported in Korea are still at a basic level, studies assessing efficacy and safety of Korean medicine for breastfeeding mothers are being conducted, and there are many Korean medicine literatures explaining Korean medicine approaches to breastfeeding mothers. Therefore, it is considered that the possibility of Korean medicine treatment for the problems that mothers face during lactation has great potential.

제2형 당뇨병 환자에서 혈당강하제와 보중익기탕 병용 투여가 혈당 변화에 미치는 영향 및 안전성 연구

오승현,정우녕,송미령,노지원,안영민,안세영,이병철,Seung-hyun Oh,Woo-nyoung Jung,Mee-ryoung Song,Ji-won Noh,Young-min Ahn,Se-young Ahn,Byung-cheol Lee 대한한방내과학회 2023 大韓韓方內科學會誌 Vol.44 No.3

Objective: This study aimed to assess the safety and effect on glucose level of Bojungikgi-tang in patients with type 2 diabetes mellitus. Methods: To review patients' clinical characteristics and laboratory tests retrospectively, we investigated 15 hospitalized patients with type 2 diabetes mellitus who took Bojungikgi-tang at Kyung Hee University Korean Medical Hospital for at least one day between January 2012 and December 2022. The blood glucose levels, including fasting blood sugar (FBS), 2-hour postprandial glucose (PP2) levels, and glycated hemoglobin level, were collected to determine the effect of the Bojungikgi-tang on blood sugar changes. Furthermore, to evaluate the safety of Bojungikgi-tang, hepatic function and renal function tests were implemented, including aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, γ-glutamyltransferase, blood urea nitrogen, creatinine, and Modification of Diet in Renal Disease estimated glomerular filtration rate. Results: When Bojungikgi-tang and a standard treatment for diabetes were administered for patients with type 2 diabetes, it was confirmed that there were no statistically significant changes in FBS and PP2 levels in the analysis of each medication taken. There was no significant difference in the safety profile after taking Bojungikgi-tang. Conclusions: The combined administration of Bojungikgi-tang with standard hypoglycemic medication for patients with type 2 diabetes may not affect blood glucose levels and safety.

IgA 신병증 환자의 침구 치료 치험 1례

이민승,오승현,정우녕,노지원,안영민,안세영,이병철,Lee, Min-seong,Oh, Seung-hyun,Jung, Woo-nyoung,Noh, Ji-won,Ahn, Young-min,Ahn, Se-young,Lee, Byung-cheol 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.5

Objective: This study was conducted to investigate whether acupuncture and moxibustion treatment could improve proteinuria in immunoglobulin A nephropathy. Methods: A 25-year-old man diagnosed with immunoglobulin A nephropathy had severely increased proteinuria. We conducted acupuncture treatment and moxibustion treatment on the abdominal area between the abdominal aorta and kidney at level L2. Results: After five months of acupuncture and moxibustion treatment, the patient's urine albumin/creatinine ratio and urine protein/creatinine ratio had improved from 0.571 to 0.28 and 0.79 to 0.47, respectively. Conclusions: This case report suggests that acupuncture and moxibustion treatment may ameliorate proteinuria in immunoglobulin A nephropathy.

표준 치료를 받고 있는 제2형 당뇨병 환자에 대한 구미강활탕, 평위산, 반하사심탕 복용이 혈당에 미치는 영향 및 안전성 연구

오승현,이민승,정우녕,노지원,안영민,안세영,이병철 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.3

Objective: This study was conducted to evaluate the hypoglycemic effect and safety of herbal extracts in patients with type 2 diabetes mellitus. Methods: We investigated 19 hospitalized patients with type 2 diabetes mellitus who were administered Banhasasim-tang (BST), Gumiganghwal-tang (GGT), or Pyeongwee-san (PWS) at Kyung Hee University Korean Medical Hospital for at least three days between January 2012 and December 2021. Their clinical characteristics and laboratory tests were reviewed retrospectively. The glucose-lowering effect of the herbal extracts was assessed by comparing blood glucose levels, including fasting blood sugar (FBS), two-hour postprandial glucose (PP2) levels, and glycated hemoglobin levels. To evaluate the safety of the herbal extract, liver function test and kidney function test results were compared, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine (Cr). Results: After taking herbal extracts, PP2 and HbA1c levels significantly decreased from 205.82 mg/dL to 171.41 mg/dL and 7.58% to 6.62%, respectively. The safety profile reported no significant difference after taking herbal extracts. Conclusions: BST, GGT, and PWS may have hypoglycemic effects in patients with type 2 diabetes mellitus taking hypoglycemic medication.

Comparative Study on the Content and Cytotoxicity of Pseudolaric Acid B in the Five Plant Parts of Pseudolarix kaempferi

Agung Nugroho,우남태,박경식,권나윤,정우녕,이상국,김동화,박희준 한국생약학회 2017 Natural Product Sciences Vol.23 No.4

Pseudolaric acids of Pseudolarix kaempferi (Pinaceae) have been known as diterpenoids with potent anti-fungal-, anti-microbial, and cytotoxic activities. In the present study, the five MeOH extracts were prepared from the five plant part (root bark, stem bark, leaf, the inner part of root, and cone) to find the relation between the concentration of pseudolaric acids and cytotoxicity. Pseudolaric acids B and C were isolated from the root bark of P. kaempferi to use them as standard compounds. The five extracts were tested on cytotoxicity against six cancer cell lines, A549 (lung), HCT116 (colon), MDA-MB-231 (breast), SNU638 (stomach), and SK-hep-1 (liver) by SRB assay, but against K562 (leukemia) by SRB- or MTT assay. HPLC quantification were performed on a Shisheido Capcell PAK C18 column (5 mm, 4.6 mm ? 250 mm) using 254 nm wavelength. The cytotoxicity (IC50, 0.36 mg/ml on K562 cell lines) of the root bark extract was potent and the content (101.1 mg/g extract) of pseudolaric acid B was very high in the root bark. These results suggest that the MeOH extract obtained from the root bark could be developed as the anti-cancer agent with a high quantity of pseudolaric acid B.