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Triton WR-1339 복강주사로 유도된 생쥐의 고지혈증에 대한 참홑파래 추출물의 영향
정영하(Yeong Ha Jung),조용철(Yong Chul Cho),박인식(In Sick Park),안상현(Sang Hyun Ahn),김진택(Jin Taek Kim),강용주(Yong Joo Kang),홍용기(Yong Ki Hong) 한국수산과학회 1997 한국수산과학회지 Vol.30 No.5
An antihyperlipidemic effect was observed by intraperitoneal injection of the seaweed Monostroma nitidum extract. Hyperlipidemia was induced by intraperitoneal injection of Triton WR-1339(60㎍/g-body weight) into a mouse. Maximum level of blood cholesterol was reached at 20 hours after Triton injection. By simultaneous injection of the M. nitidum extract(30㎍/g-body weight) with the Triton into each right and left sides of the peritoneal cavity, levels of total cholesterol and low density lipoprotein were decreased to 24% and 14% compared to Triton injection only. For histochemical changes, hepatic tissues obtained at 40 hours after injection of the Triton and the M. nitidum extract were fixed in fromol-calcium solution. The meshlike cytoplasms disappeared and hapatic plates were recovered in mice injected with the M. nitidum extract. Numbers of lipid drops and cholesterol particles also decreased in the portal space of the hepatic cytoplasm. This indicates that the accumulation of lipid, including cholesterol, caused by Triton was prevented by the antihyperlipidemic effect of extract from the seaweed M. nitidum.
해조류 김 추출물의 Triton WR-1339 유발 고콜레스테롤혈증 감소효과
홍용기(Yong Ki Hong),박인식(In Sick Park),정영하(Yeong Ha Jung),송상호(Sang Ho Song),홍성열(Sung Youl Hong) 한국수산과학회 1998 한국수산과학회지 Vol.31 No.4
An antihypercholesterolemic effect was observed by intraperitoneal injection of the seaweed Porphyra yezoensis extract. Hypercholesterolemia was induced by intraperitoneal injection of Triton WR-1339 (600 ㎍/g-body weight)into a morose. Maximum level of blood cholesterol was reached at 20 hours after Triton injection. By simultaneous injection of the P. yezoensis extract (30㎍/g-body weight) with the Triton into each fight and left sides of the peritoneal cavity, jewels of total cholesterol rind low density lipoprotein were decreased to 37% and 24% compared to Triton injection only. For histochemical changes, hepatic tissues obtained at 40 hours after injection of the Triton and the P. yezoensis extract were fixed in fromol-calcium solution. Numbers of lipid drops and cholesterol particles decreased in the portal space of the hepatic cytoplasm. This indicates that the accumulation of lipid, including cholesterol, caused by Triton was prevented by the antihypercholesterolemic effect of extract from the seaweed P. yezoensis.