위유(胃兪)의 산사(山査) 약침(藥鍼)이 고지방(高脂肪) 식이(食餌)로 유발(誘發)된 비만백서(肥滿白鼠)에 미치는 영향(影響)

정영표,윤여충,윤대환,Jeong, Young-Pyo,Yoon, Yeo-Choong,Yoon, Dae-Hwan 대한침구의학회 2007 대한침구의학회지 Vol.24 No.4

Objectives : This research was performed to investigate the effect of herbal acupuncture(Crataegus pinnatifida) at WI-SU($BL_{21}$) on weight gain, food intake, food efficiency, serum of lipid concentrations, liver function and cardiovascular risk of rats fed high fat diet for 8weeks. Methods : Experimental groups were divided into high fat diet group(Control), high fat diet and saline in $BL_{21}$ treated group(Saline), high fat diet and Crataegus pinnatifida-herbal acupuncture in $BL_{21}$ treated group(HA-1, 0.08mg/ml/g), high fat diet and Crataegus pinnatifida-herbal acupuncture in $BL_{21}$ treated group(HA-2, 0.04mg/ml/g), high fat diet and Crataegus pinnatifida-herbal acupuncture in $BL_{21}$ treated group(HA-3, 0.016mg/ml/g), Herbal acupuncture was bilaterally treated at Crataegus pinnatifida-herbal acupuncture in both $BL_{21}$ 1time (0.2cc) per 4days, total 14 times in 56days. Results : Body weight was decreased in HA-1 and food efficiency was decreased in HA-1, HA-3. Feed intake was increased in HA-3. The level of serum total cholesterol was decreased in Saline, HA-1, HA-2, HA-3. The level of serum HDL-cholesterol was increased in HA-1, but LDL-cholesterol was not significant. The level of serum triglyceride was decreased in HA-1, HA-2, HA-3. and the level of serum Total Bilirubin was decreased in HA-1. The level of serum Atherogenic index was decreased in HA-1, HA-2, HA-3. and the level of serum HTR was increased in HA-3. The evel of serum AST, ALT were increased in saline, and the level of serum r-GTP was not significant. Conclusions : Crataegus pinnatifida acupuncture in Wi-Su($BL_{21}$) can control the body weight, feed intake and feed efficiency ratio, total cholesterol, HDL-cholesterol, triglyceride, total bilirubin, and prevention cardiovascular risk. And Crataegus pinnatifida acupuncture is not injurious on liver function.

협척혈(夾脊穴)에 전침(電鍼)을 이용한 척추전방전위증 환자에 대한 임상적 고찰

정영표,정효근,강수우,위준,윤여충,채우석,위통순,Jung, Young-Pyo,Jung, Hyo-Keun,Chiang, Suo-Yue,Wi, Jun,Yoon, Yeo-Choong,Chae, Woo-Seok,Wei, Tung-Shuen 대한침구의학회 2008 대한침구의학회지 Vol.25 No.1

Objectives : The study was performed to evaluate the effect of treatment for spondylolisthesis by using electroacupuncture at Hua-Tuo-Jia-Ji-Xue is located about 0.5Cun(寸) at both sides of spinous process of each vertebra. Methods : This clinical study was carried out 5 case with spondylolisthesis, who had bean treated from December, 2006 to November, 2007, in the department of acupuncture and moxibustion, Dongshin University Oriental Medical Hospital. We treated the patient who was diagnosed as spondylolisthesis by simple X-ray or MRI. Results : 1. Degenerative type is 3 cases, and isthmic type is 2 cases. 2. In the distribution of injured level was between 4-5th lumbar vertebra the most(3 cases). 3. The improvement index showed 0.29, 0.56, 0.43 points in degerative type, and 0.39, 0.36 points in isthmic type. 4. Therapeutic efforts above "good" by Kim's criteria was 4 cases. 5. Good improvement was showed in VAS about average 3.4. Conclusions : There was reports about Hua-Tuo-Jia-Ji-Xue electronic acupuncture treatment of patients with spondylolisthesis. It is very effective to improve condition of patients with spondylolisthesis.

감염근관내(感染根管內) 수종균(數種菌)에 대(對)한 항생제(抗生劑)의 감수성검사(感受性檢査)에 관(關)한 실험적(實驗的) 연구(硏究)

정영표,민병순,최호영,박상진,Chung, Young-Pyo,Min, Byung-Soon,Choi, Ho-Young,Park, Sang-Jin 대한치과보존학회 1983 Restorative Dentistry & Endodontics Vol.9 No.1

The rational approach to antimicrobial therapy of infected root canals is based on accurate identification of the infecting organism and on the organism's susceptibility to antimicrobial agents as measured by standardized techniques. In establishing criteria for the selection of antibiotics, a susceptibility test should be performed. The purpose of this study was to investigate the susceptibility of 224 aerobic and anaerobic microbial strains isolated from infected root canals to various antibiotics. This was performed by using 7 antibiotic sensi-disc: Penicillin (10 units), Ampicillin (10 mcg), Tetracycline (30 mcg), Streptomycin (10 mcg), Kanamycin (30 mcg), Lincomycin (2 mcg), and Clindamycin (2 mcg). The results were as follows; 1. Strains isolated from infected root canals was shown to be most susceptible to Clindamycin, while Streptomycin exhibited least antibacterial properties. 2. Anaerobes were found to be susceptible to Penicillin, Ampicillin, and Clindamycin. 3. Streptomycin and Kanamycin were shown to be effective against Staphylococcus aureus and Staphylococcus epidermis, however, unidentified G(+) cocci organisms were found to be resistant to these agents. 4. Bifidobacterium sp. was susceptible to Lincomycin while G(+) rods were resistant to it. 5. Staphylococcus aureus, Micrococcus sp., and anaerobes were highly susceptible to Clindamycin. 6. All of the antibiotics tested were shown to be very effective against Eubacterium sp.

제왕절개술 환자에서 Fentanyl-Ketorolac-Droperidol과 Nalbuphine-Ketorolac-Droperidol의 술후 진통효과 비교

이재상(Jae Sang Lee),정영표(Young Pyo Cheong),이강 대한통증학회 1995 The Korean Journal of Pain Vol.8 No.2

N/A Opioids produce strong analgesic effect result with some side effects such as nausea, vomiting, urinary retention, somnolence, and respiratory depression. Nalbuphine, an ago- nist-antagonist has, at low doses, an analgesic potency comparable to morphine with little side effects. Analgesic effect after continuous infusion of fentanyl-ketorolac-droperidol, or Nubain®-ketorolac-droperidol combination in Cesarean section patients were assessed by numerical rating scale(NRS) and Prince Hednry scale (PHS), The patients were divided into two groups. Each group consists of 30 patients. Group l received 20 μg of fentanyl the end of surgery. And then continuously infused with additional 380 μg of fentanyl plus l20 mg of ketorolac and 2.5 mg of droperidol. Group 2 initially received 2 mg of Nubain® at the end of surgery and the remaining dose of Nubain® 38 mg plus ketorolac 120 mg and droperidol 2.5 mg was continuously infused. With all patients, initial dose of drug was administered by bolus of i.v. injection and the remain- ing dose was administered via i.v. using a Baxter Two Infusor® Pain scores and side effects were recorded at the time of recovery room arrival, and at interval of 30 min, 1 hr, 6 hr, l2 hr, 24 hr, 48 hr after start of continuous infusion. No sig- nificant difference was found between the pain scores and side effects of both groups although pain control effect was excellent in both groups. We concluded that Nubain® could be an alternative to fentanyl for postoperative pain control.

삼차신경통 환자에서의 알콜올 신경차단 - 41예 분석 -

김 찬(Chan Kim),정영표(Young Pyo Cheong),임현교(Hy 대한통증학회 1994 The Korean Journal of Pain Vol.7 No.1

N/A The purpose of this study was to review the results of the neurolytic trigeminal nerve block in 41 patients from April 1992 to March 1994. Most common site of trigeminal neuralgia was the second division(27patients, 68.3%). Nine- teen patients of these were treated with infraorbital nerve block. Another 4 patients had cerebello-pontine angle tumor close to TREZ in MRI findings theiefore they were excluded from this study. Thirty nine patients(95.1%) remajned free of pain. Only 2 patients treated with infraorbital nerve block experienced recurring pain. Although the follow-up period was short, alcohol blocks proved effective and safe for treat- ment of trigeminal neuralgia.

신경통증과 환자의 임상통계 고찰

신소현(So Hyun Shin),정영표(Young Pyo Cheong),임재 대한통증학회 1994 The Korean Journal of Pain Vol.7 No.1

N/A Retrospective analysis, of 1,734 patients treated for nerve block from October 1991 to March 1994. Largest percentage of patients were in the 50 year old range, with a distribution of 44.9% male and 55.1% female. Treatments were for ailments of: Low Back Pain 17.3%, Multiple Con- tusion 10.5%, and Cancer 10%. Most common nerve block was epidural block 38.6%, followed by stellate ganglion block 38.4%, intercostal block 5.4%, and suprascapular nerve block 5.2%. Nerve block under fluorscopic guide were as follows: facet joint block 34.1%, lumbar sympa- thetic ganglion block 13.6%, and celiac plexus block 12.9%

경막외 Morphine의 첨가제로 사용한 Fentanyl과 Bupivacaine의 술후 진통효과 비교

안선연(Sun Yeon An),손 용(Yong Son),정영표(Young P 대한통증학회 1997 The Korean Journal of Pain Vol.10 No.2

N/A Backgound: The present study was undertaken to determine whether fentanyl or bupivacaine is a better adjuvant to epidural morphine with respect to postoperative analgesic use and with fewer incidence of side effects. Methods: We evaluated the clinical effects in 62 patients having cesarean section, divided in 3groups randomly. Group I(n 19) was received epidural marphine 4 mg, group II(n=22) was received epidural morphine 2 mg plus fentanyl 50 μg and group III(n=21) was received morphine 2 mg plus 0.25% bupivacaine 10 ml epidurally. We measured the first request time of analgesic for postoperative pain, the number of supplemental analgesics within 24 hours and the incidence of side effects postoperatively. Results: The first request time of analgesic for postoperative pain was significantly shorter in group III than in group I and IL The analgesic use in the first 24 hours was significantly more in group III than in group I and II. The side effects were significantly fewer incidence in group II than in group I and III. Conclusions: In conclusion, the combined use of epidural morphine and fentanyl provided better analgesia than the combined of epidural morphine and bupivacaine.

몰핀이 신경아세포종 SH-SY5Y 세포에서 Peroxynitrite에 의한 세포고사를 막는 것은 아편양 수용체나 Phosphatidylinositol-3 kinase (PI-3 kinase) 경로의 활성화에 의한 것이 아니다

정영표,이동렬,손용,김태요,윤재승,송윤강,김명선,박래길 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: The effect of opioids on nitric oxide (NO)- and peroxynitrite-induced neuronal cell death is largely unknown. In the present study, we examined the effect of morphine on NO- and peroxynitrite-induced cell death using a human neuroblastoma SH-SY5Y cell line, which abundantly expresses μ, δ, k-opioid receptors. Methods: The cultured cells were pretreated with morphine and exposed to 3-morpholinosydnonimine (SIN-1) that simultaneously generates NO and superoxide, thus possibly forming peroxynitrite. The cell damage was assessed by using MTT assay ana crystal violet staining. Exposure of the cells to SIN-1 for 24 hours induced apoptotic cell death, as evaluated by the occurrence of morphological nuclear changes characteristics of apoptosis using 4', 6-diamidino-2-phenylindole (DAPI) and measurement of pro-apoptotic protease, caspase-3, activity. Results: Pretreatment of SH-SY5Y with morphine, significantly inhibited the apoptotic cell death in a dose-dependent manner. Morphine also inhibited SIN-1-induced proapoptotic protease, caspase-3, activity in a dose-dependent manner. However, naloxone (20 μM) hardly antagonized the effect of morphine in SIN-1-induced cell death. The selective ligands for opioid receptor subtypes, [D-Ala^2, N-Me-Phe^4, Gly-ol^5]enkephalin (DAMGO, μ-opioid receptor agonist), [D-Pen^2.5]enkephalin (DPDPE, δ-opioid receptor agonist) and U-69593 (k-opioid receptor agonist) at the concentration of 10 μM did not prevent the cell death induced by SIN-1. PI3-kinase inhibitors, Wortmannin and LY294002, did not inhibit the action of morphine on apoptotic cell death. The neuroblastoma cells treated with morphine significantly elevated glutathione levels (GSH). Conclusions: The present study showed that morphine protected human neuroblastoma cell line, SH-SY45Y, from the peroxynitrite-induced apoptotic cell death through elevated GSH levels. However, it is suggested that the elevation of GSH by morphine is not via the activation of opioid receptors and/or PI3-kinase pathway but via other unknown mechanism.

진성 다혈구증 환자에서 수술전 적혈구 성분채집술 이용 1례 : 증례보고 A Case report

정영표,이영진 圓光大學校 醫科學硏究所 1997 圓光醫科學 Vol.13 No.1-2

Elective surgery should not be performed in uncontrolled polycythemia vera (PV), since hemorrhage and thrombotic complications lead to a markedly increased perioperative mortality. The usual method to controlling PV is a phlebotomy with drug therapy. Prior to surgery, instead of phlebotomy, we used erythrocytapheresis for controlling 57-year-old male PV patient scheduled for total right hip replacement and have a excellent controlling effect. No serious perioperative complication due to PV was not developed and he was discharged at 16th day after operation. Erythrocytapheresis has the more feasibility of controlling PV compare with phlebotomy, so its use must be spread widely as possible.

전신마취하 대퇴골 골수강내 고정술후 발생한 폐색전증 : 증례보고 a case report

손용,정영표 圓光大學校 醫科學硏究所 1997 圓光醫科學 Vol.13 No.1-2

Pulmonary thromboembolism(PTE) is a serious postoperative complication. Prompt diagnosis of PTE is important but it is difficult because clinical manifestations of PTE are not obvious in most cases. A 35 year-old man received a operation for the left femur fracture under general anesthesia. From the anesthetic arousal, hypoxemia in room air was developed. But the response to the oxygen therapy was good and there was no any other pathologic findings except mild hypoxemia. Possible causes of postoperative hypoxemia were ruled out and then PTE was suspected and diagnosed with lung perfusion scan and pulmonary artery angiography. He was transfered to ICU and received proper anticoagulant therapy. He was recovered and discharged in improved condition. In conclusion, if a patient have a unexplained hypoxemia in postoperative period, PTE must be thought to be an one of possible causes and thoroughly investigated especially in the high risk group of PTE.