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원발성 폐암에서 p53 의 발현과 S - Phase Fraction 및 예후와의 관계
정은택(Eun Taik Jeong),양세훈(Sei Hoon Yang),김학렬(Hak Ryul Kim),정병학(Byung Hak Jeong),문형배(Hyung Bae Moon) 대한내과학회 1996 대한내과학회지 Vol.51 No.5
N/A Objectives: The p53 has been implicated in the control of cell cycle, DNA repair and programmed cell death especially, arrest of the cell cycle at G1 phase during DNA damage and repair. It is now widely accepted that mutations of p53 are among the most common changes that occur during malignant progression of diverse types of cancer. Based on this information, it seems reasonable to expect that there may be clinical prognostic significance of p53 changes in primary lung cancer. But its prognostic significance is controversial. Methods: To investigate the role of p53 mutation in lung cancer, we performed immunohistochemical stain of p53 on 57 resected primary non-small cell lung cancer specimens, thereafter, flow cytometric cell cycle analysis was done. And we analyzed the correlation between p53 expression, S-phase fraction and survival. Results: 1) p53 was detected in 70% of total 57 patients (according to histologic type, squamous carcinoma 74%, adenocarcinoma 69%, large Cell carcinoma 33%). p53 was positive in 71% of stage 1, 76% of stage 2, 63% of stage 3a, 67% of stage 3b (statistic insignificance). 2) Using the flow cytometric cell cycle analysis, mean S-phase fraction of p53(+) and (-) group are 21.3 (±7.4)%, 16.5 (±6.4)% (p<0.05) and mean G1 phase fraction of p53(+) and (-) group are 67.9 (±9.8)%, 75.4 (±10.5)% (p<0.05). 3) The median survival time of mt p53(+) and (-) group are 29.3 months, 39.5 months, but this could not reach the statistic significance. Conclusion: p53 was detected in 70% of primary non-small cell lung cancers. The S-phase fraction of p53(+) group was longer than (-) group (p<0.05). But, p53 could not be a prognostic factor.
양세훈,최두환,정병학,정은택,윤기중,문형배 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2
Mucormycosis is a rapidly progressive disease with a fatal prognosis. It emcompasses a distinctive group of infections caused by fungi belonging to order Mucorales. Pulmonary mucormycosis is an uncommon opportunistic fungal infection associated with diabetes mellitus. leukemia, lymphoma and other immune compromised status. Their clinical presentations depend on the associated underlying disorders. In generally, patients with leukemia and lymphoma often have fatal prognosis, who have a tendency of diffuse parenchymal disease refractory to medical treatments. But. patients with diabetes mellitus have a tendency to develop a localized endobronchial disease in major airway which is susceptible to therapy with Amphotericin B. We have experienced a case of endobronchial mucormycosis with diabetes mellitus, which was cured with antifungal therapy and diabetic control.
김태현,문형배,최순호,장근,정병학,채권묵,정은택,강정성 대한내과학회 1993 대한내과학회지 Vol.45 No.4
Hydatid cystic disease is a kind of cestoda infection by the larval form of Echinococcus from the intestine of dogs. The incidence of hydatid cyst is high in Middle East, Oceanic area, but still rare in Korea. We experienced a case with hepatic and pulmonary hydatid cystic disease. The patient was 50 year-old male, had a history of working in the Saudi arabia and Iraq. His only complaint was chest discomfort. CT scans of chest and abdoman revealed a large unilocular cyst in the liver and five cysts in the upper lobe of right lung. Complete resection of pulmory cysts was done. Per-cutaneous aspiration with hypertonic sclerosing of hepatic cyst was also performed. The pathologic findings were the characteristic pattern of brood capsule, scolecies and hydatid sands of echinococcus in the cysts.