셀레나이트로 유도되는 백내장에서 선삼 성분에 따른 백내장 억제효과의 비교 분석

이상목,정문선,정진호,김미금,위원량,박정일,이진학,Sang Mok Lee,MD,Jung Moon Sun,MD,Jin Ho Jeong,MD,Mee Kum Kim,MD,Won Ryang Wee,MD,Jeong Hill Park,PhD,Jin Hak Lee,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.5

Purpose: To compare the protective effects of saponin and non-saponin Sun-ginseng extract fractions in a selenite-induced rat cataract model. Methods: A total of 101 Sprague-Dawley rat pups were divided into four groups by treatment: Sun-ginseng, saponin fraction, non-saponin fraction, and control. For induction of cataracts, sodium selenite 15 nmol/g was injected subcutaneously in 13 day-old rat pups. Sun-ginseng extract 100 μg/g (Group I, Ginseng Science, Seoul, Korea), saponin fraction 100 μg/g (Group II), non-saponin fraction 100 μg/g (Group III), and phosphate buffered saline (Control group) were injected intraperitoneally every two days for a total of seven injections. The rats were sacrified and their lenses were dissected and photographed at day 7 and 14, and the cataracts were graded according to the ratio of the cataract area to the total lens area. The blind method was used for the evaluation of the cataract area. Results: At day 14, cataract formation rates (CFR) were 33.3% in group I, 76.4% in group II, 41.2% in group III, and 77.7% in the control group. The mean cataract area (MCA) was 13.4±20.8% in group I, 14.4±11.7% in group II, 5.7±7.7% in group III, and 15.8±12.1% in the control group. Group III showed statistically significant results compared with those of control group (CFR p=0.001, MCA p=0.001). We observed significantly lower incidence and smaller mean cataract area in Group I and Group III at day 7 compared with the control group (Group I, CFR p=0.018; Group III, CFR p=0.032, MCA p=0.005). Conclusions: The protective effects of Sun-ginseng extract are caused by the components in the non-saponin fraction, not by those in the saponin fraction, in a selenite-induced cataract rat model. J Korean Ophthalmol Soc 2010;51(5):733-739

간헐외사시 소아의 자연 경과

정문선 ( Moon Sun Jung ),최미영 ( Mi Young Choi ) 대한안과학회 2003 대한안과학회지 Vol.44 No.7

한국 의료관광의 제약요인과 성공가능방안에 관한 연구: 근거이론적 접근

정문선(Jung, Moon-Sun),박호남(Piao, Hu-Nan),황현희(Hwang, Hyeon-hee),김근배(Kim, Kun-bae) 한국관광레저학회 2019 관광레저연구 Vol.31 No.11

Deacon방정식을 이용한 보정계수의 추정

정문선(Jung Moon-sun),문채주(Moon ChaeJoo),정의헌(Cheang Eui-Heang),김태훈(Kim Tae-Hoon),장영학(Chang Young-Hak) 한국태양에너지학회 2010 한국태양에너지학회 학술대회논문집 Vol.2010 No.4

Vertical distribution of wind speed is subjected to the Power Law on wind speed and height. 10m high Met Mast which was set up by Korea Meteorological Administration to measure wind speed aiming at analyzing its impact on human life can't be used in forecasting wind power generation. Therefore, it is general to operate the Met Mast for the purpose of investigating the validity of wind power generation, and the height of a mast is becoming higher as most of current size of wind power generators requiring higher masts. However, it is more common to installation it within 60m height due to economical factors and permission/approval system factors. Height correction wind speed is calculated by using Deacon equation, and surrounding area's geometrical mean height, ground roughness , measure height are included in internal parameter. In addition to this, by applying 2 data of actual measurement of wind speed which is acquired in different height into Deacon equation, it is calculated by extrapolation. In this study, by comparing vertical distribution which is calculated using Roughness length rating of Risø and Roughness length rating in accordance of USGS vegetation analysis, the result is inputted into Deacon equation's illuminance index, and it is compared with actual measurement of wind speed to suggest recommendations for illumination index, and its rating classification methods which has to be applied to Deacon equation in domestic complicated area and costal area.

연구논문 : 모더니즘 시와 영화기법 - 박인환 시의 시간의식과 화자의 시선 이동을 중심으로 -

정문선(Moon Sun Jung) 시학과 언어학회 2001 시학과 언어학 Vol.1 No.-

Comparisons of upwind numerical scheme for a hyperbolic two-fluid model

Moon-Sun Chung(정문선),Youn-Gyu Jung(정연규),Sung-Jae Lee(이성재) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10

A lot of upwind scheme has been developed for simulating high speed, single-phase flows and some of them prove to be very successful. However, all of these numerical schemes cannot be applied for two-phase flow problems due to their complexity relating the interfacial phenomena between two phases of fluid. For this reason, sometimes we need to find an optimal numerical scheme in order to adopt a prominent upwind scheme to the hyperbolic two-fluid model for two-phase flows. Before choosing an upwind numerical scheme, we need to compare some candidates by solving benchmark problems. In this study, we compare the Flux Vector Splitting (FVS) scheme with the Harten, Lax and van Leer (HLL) scheme for a hyperbolic two-fluid model for 1D. equation system and analyze their advantage and disadvantage by calculating the two-phase shock-tube problem.

대전충청 지역 세균각막염 환자의 연령에 따른 임상 분석 : 다병원 연구

윤정석(Jung Suk Yoon),이종욱(Jong-uk Lee),이정우(Jungwoo Lee),김주은(Ju Eun Kim),이환호(Hwanho Lee),김현태(Hyun Tae Kim),조경진(Kyong Jin Cho),정문선(Moon Sun Jung),최시환(Si Hwan Choi),고병이(Byung Yi Ko) 대한안과학회 2020 대한안과학회지 Vol.61 No.12

목적: 대전충청 지역의 세균각막염의 연령에 따른 임상양상 및 위험인자, 예후에 대해 알아보고 퀴놀론계 항생제 내성균의 양상 및 변화에 대해 알아보고자 하였다. 대상과 방법: 2000년 1월부터 2018년 12월까지 대전충청 지역 5개 대학병원 안과에서, 배양검사를 통해 세균각막염으로 진단된 환자 433명(433안)을 대상으로 60세 기준으로 고연령군과 저연령군으로 나누어 감염원인, 예후인자, 치료법, 원인균, 퀴놀론계 항생제 감수성 등을 후향적으로 연구하였다. 결과: 남자가 273명(63%), 여자가 160명(37%)이었다. 저연령군에서 가장 흔한 위험인자는 콘택트렌즈 착용(27.5%)과 외상 및 이물(27%)이었고, 고연령군에서 가장 흔한 위험인자는 외상 및 이물(30.5%)이었다. 원인균으로는 연령에 상관없이 그람양성균 중 포도알균종이 가장 많았고, 그람음성균 중에서는 녹농균이 가장 많았다. 고연령군에서는 저연령군보다 각막염의 정도가 심하고, 수술적 치료를 요하는 경우가 많았으며, 시력예후도 더 나쁜 결과를 보였다(p<0.05). 2011년을 기준으로 퀴놀론계 항생제에 대한 내성은 두 군 간에 통계적으로 차이가 없었다(p>0.05). 결론: 대전충청 지역의 세균각막염은 고연령군에서 더 심하고, 예후도 나쁜 양상을 보이며, 이는 타 지역을 대상으로 한 연구와 비슷한 결과를 보인다. 모든 연령군에서 외상 및 이물에 대한 주의와 기존 안질환의 관리가 필요하고, 저연령군에서는 콘택트렌즈 착용에 대한 교육 및 위생관리가 필요할 것으로 사료된다. Purpose: The purpose of this study was to investigate the age-related clinical features, risk factors, and prognoses of bacterial keratitis in Daejeon and Chungcheong provinces and the patterns and trends of fluoroquinolone antibiotic susceptibility. Methods: Medical records of 433 patients (433 eyes) who visited one of the five university hospitals in Daejeon and Chungcheong provinces and were diagnosed as culture-positive bacterial keratitis between January 2000 to December 2018 were reviewed retrospectively. The patients were divided into younger and older groups based on an age of 60 years. Predisposing factors, prognostic factors, treatment method, causative organisms, and susceptibility to fluoroquinolone were analyzed. Results: Two hundred seventy three males (63.0%) and 160 females (37.0%) were included. The most common risk factors in the younger group were contact lens wear (27.5%) and trauma and foreign body (27.0%). The most common risk factors in the older group were trauma and foreign body (30.5%). Staphylococcus species was the most common causative Gram-positive bacteria, regardless of age, and Pseudomonas species was the most common among Gram-negative bacteria. The older group tended to have more severe keratitis required more surgical treatment and had a worse visual outcome than the younger group (p < 0.05). As of 2011, the resistance to fluoroquinolone did not differ significantly between the groups (p > 0.05). Conclusions: Bacterial keratitis in Daejeon and Chungcheong provinces indicated more severe clinical aspects and worse prognoses in older patients showing similar results from previous studies. Caution regarding trauma and foreign bodies and managing previous ocular disease is necessary for all age groups. Education regarding adequate contact lens care and hygiene is required for younger (<60 years) patients.

전층각막이식 봉합사 제거 후 외상에 의해 발생한 지연성 축출성 맥락막상강출혈 1예

최연주,정문선,Youn Joo Choi,Moon Sun Jung 대한안과학회 2011 대한안과학회지 Vol.52 No.3

Purpose: To report a case of delayed-onset expulsive suprachoroidal hemorrhage due to trauma after removal of a penetrating keratoplasty suture. Case summary: A 66-year-old man had penetrating keratoplasty for bullous keratopathy performed in his left eye. After 1 year, the continuous suture was removed for adjustment of astigmatism. Four days after removal of the suture, the patient struck his left eye with the back of his hand, although at the time of injury he had no specific symptoms. Two days later, the patient noticed abrupt pain, decreased visual acuity, and massive hemorrhage in his left eye. Examination revealed an inferior wound dehiscence of approximately 8 clock hours (2 thru 10 o’clock) with prolapsed intraocular contents such as the uvea and retina. The patient underwent cornea graft resuturing with resection of ocular contents, which could not be repositioned. Although bleeding was controlled after the operation, vision was lost in his left eye. After two months, according to decrement of intraocular hematoma, the patient had a phthisis bulbi with low intraocular pressure in his left eye. Conclusions: Persistent low intraocular pressure due to wound leakage through the graft-host junction likely resulted in delayed onset of expulsive suprachoroidal hemorrhage. The risk of traumatic corneal graft rupture after penetrating keratoplasty is significant and is associated with a poor visual outcome and eyeball viability. Therefore, patients should be cautioned. In addition, the importance of eye examination after trauma should be emphasized. J Korean Ophthalmol Soc 2011;52(3):359-363

신생아의 안과검사에서 발견된 안과적인 이상

이자영,정문선,김소영,Ja Young Lee,Moon Sun Jung,So Young Kim 대한안과학회 2011 대한안과학회지 Vol.52 No.2

Purpose: To investigate incidental abnormal ocular findings that may cause visual impairment in neonates. Methods: The medical records of patients requested for screening for retinopathy of prematurity (ROP) at our hospital’s pediatrics department between March 2005 and July 2009 were retrospectively reviewed. Patients were classified into premature and mature neonates according to gestational age (under 37 weeks). Results: A total of 2,090 eyes from 1,045 patients were comprised of 1,514 eyes of 757 premature neonates and 576 eyes of 288 mature neonates. Among 154 eyes of 78 patients (10.17%) who were diagnosed with ROP, 34 eyes of 18 patients had laser treatment. Seven eyes of 5 patients in the premature neonate group (0.46%), and 38 eyes of 23 patients in the mature neonate group (6.57%) were found to have abnormal ocular findings, excluding incidental ROP. Twenty-six eyes of 16 patients were found to have a retinal hemorrhage, and the majority had a birth history of perinatal distress, including birth asphyxia, meconium aspiration, and transient tachypnea of the newborn. Other findings included congenital cataracts, corneal opacity, macular coloboma, persistent hyperplastic primary vitreous, and abnormal fundus. Conclusions: The incidence of ocular abnormalities in neonates that cause visual impairment is low, but theses may threaten a child’s life. Early detection and prompt treatment of ocular disorders in children are important in order to avoid permanent, lifelong visual impairment. Therefore, ophthalmic examinations are essential, even in normal neonates, for early detection of ocular disorders. J Korean Ophthalmol Soc 2011;52(2):222-226

마이크로 pin fin 화학반응기에서 수소화붕소나트륨 수용액의 압력강하 및 탈수소 화학반응 연구

정기문(Ki Moon Jung),최석현(Seok Hyun Choi),정문선(Moon-Sun Chung),이희준(Hee Joon Lee) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11

Many types of hydrogen storages have been studied recently paying attention to hydrogen storage and release. Among those, dehydrogenation from the hydrolysis of a sodium borohydride (NaBH₄) solution has been of much interest owing to its high theoretical hydrogen storage capacity (10.8 wt.%) and potentially safe operation. However, most of researchers have focused on chemical characteristics such as NaBH4 hydrolysis, catalysts, and synthesis, but not on the mechanical design of a chemical reactor for hydrogen generation. To design an efficient chemical reactor, size (which should be compact) and pressure drop, reaction rate are of great importance. Therefore, a microchannel is promising for the design of a dehydrogenation reactor owing to its very large reacting surface area per unit volume. Moreover, micro size pin fin structures could be manufactured on the bottom of microchannel surface for even more extended reacting surface area and contact catalytic reaction. An experiment study has been performed on catalytic reaction rate and pressure drop of NaBH4 solution over both a single microchannel with a hydraulic diameter of 300 ㎛ and a staggered array of micro pin fins with hydraulic diameter of 50 ㎛ in the microchannel. Catalytic reaction rates and pressure drops were obtained over Reynolds numbers from 1 to 60 and solution concentration from 5 to 20 wt.%. Moreover, reacting flows were visualized using a high-speed camera with a macro zoom lens. As a result, both the amount of hydrogenation and pressure drop are 2.45 times and 1.5 times more in pin fin microchannel than in a single microchannel, respectively.