폴리감마글루탐산의 체외에서의 사이토카인 분비에의 영향

정기헌 ( Ki Heon Jeong ),문성혁 ( Sung Hyuk Moon ),최정휘 ( Jeong Hwee Choi ),이진우 ( Jin Woo Lee ),김낙인 ( Nack In Kim ) 경희대학교 경희의료원 2011 慶熙醫學 Vol.27 No.1

Background: Poly-γ-Glutamic acid (γ-PGA) is a safe and biodegradable polymer that is produced by Bacillus subtilis. Recent research showed that γ-PGA can be used as an immune-stimulating and anti-tumor agent. But the mechanism of its actions is still unexplored. Objective: To investigate the further define the potential of γ-PGA as a modifier of monocyte activity. Methods: Peripheral blood mononuclear cells (PBMNC), obtained from three healthy volunteers, were incubated after treated with lower molecular γ- PGA (1000 Da) and higher molecular γ-PGA (5000 kDa). The levels of the cytokines IL-1β, IFN-γ and TNF-α were measured. We then examined the levels of these inflammatory cytokines after treated with lipopolysaccharide (LPS) in the presence or absence of γ-PGA. Results: Low or high molecular γ-PGA alone induced release of IL-1β, IFN-γ and TNF-α significantly. High molecular γ-PGA induced more cytokines response than low molecular γ-PGA. LPS induced IL-1β, IFN-γ and TNF-α synthesis was enhanced significantly. This effect was augmented significantly by costimulation with LPS/high molecular γ-PGA versus LSP alone. Conclusion: These results suggest that γ-PGA, especially high molecular γ-PGA, play a role in immune response. As a potent immune modifier, PGA contributes to stimulation of immune responses.

전신 스테로이드제와 단파장 자외선 B로 치료한 임산부의 전신성 농포성 건선

정기헌 ( Ki Heon Jeong ),신민경 ( Min Kyung Shin ),양윤석 ( Yun Seok Yang ),김낙인 ( Nack In Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.11

Generalized pustular psoriasis of pregnancy (GPPP) is a rare form of pustular psoriasis that occurs in pregnant women during the third trimester. It is characterized by erythematous plaques, peripheral scale and sterile pustules, and this malady is associated with systemic symptoms such as fever, malaise, diarrhea and pain. A 34-year-old primigravida woman with an intermittent history of plaque psoriasis for 12 years presented with a two week history of increasingly widespread erythematous eruptions and associated peripheral pustules. The histopathologic findings were consistent with pustular psoriasis. She was diagnosed with generalized pustular psoriasis of pregnancy and she was treated with systemic and topical steroid, narrowband ultraviolet B phototherapy and wet dressings. 2 weeks after treatment, the patient demonstrated clinical and symptomatic improvement. (Korean J Dermatol 2008; 46(11): 1551∼1554)

다모증이 동반된 유아기 섬유성 과오종

정기헌 ( Ki Heon Jeong ),신민경 ( Min Kyung Shin ),이무형 ( Mu Hyoung Lee ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.8

Fibrous hamartoma of infancy (FHI) is a rare benign lesion occurring in the first 2 years of life, particularly in males. Most lesions present as a painless subcutaneous mass. Although the lesion is not distinctive clinically, it has a characteristic microscopic appearance. The lesion histologically consists of three different tissue elements: disorderly collagenous fibrous tissue, myxoid mesenchymal tissue and islands of mature adipocytes. A few cases have overlying skin changes, including alteration in pigmentation, eccrine gland hyperplasia, and increased hair. A 6-month-old male infant had a 6×4 cm sized asymptomatic mass on the right lower back. Multiple coarse hairs were present on the surface. Histopathologic findings showed the typical features of FHI, that is well defined intersecting fibrous trabeculae, small immature cells within loosely textured areas, and mature adipose areas in the lower dermis and subcutaneous layer. Immunohistochemically, vimentin was present in both the trabecular and loosely textured areas, but desmin was not present in any of the components. We report a case of FHI on the right lower back with overlying hypertrichosis in a 6-month-old male patient. (Korean J Dermatol 2008;46(8):1065~1068)

Bortezomib과 Radiotherapy 혼합요법으로 호전을 보인 피부형질세포종

정기헌 ( Ki Heon Jeong ),윤휘중 ( Hwi Joong Yoon ),이무형 ( Mu Hyoung Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.4

Multiple myeloma is a hematologic malignancy characterized by the proliferation of monoclonal plasma cells that produce monoclonal immunoglobulins. Cutaneous involvement is very uncommon in patients with multiple myeloma. It usually appears late in the course of the disease. Bortezomib is a potent proteasome inhibitor, recently introduced in the treatment of multiple myeloma. It has proven to be safe and effective in the treatment of refractory or relapsed multiple myeloma. In this study, we show the high efficacy of a concurrent therapeutic approach with bortezomib and radiation in a patient with a cutaneous plasmacytoma. (Korean J Dermatol 2009;47(4):483~486)

Subungual Exostosis의 임상, 조직학 및 영상의학 소견

정기헌 ( Ki Heon Jeong ),이무형 ( Mu Hyoung Lee ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.1

Background: Subungual exostosis is a rare, solitary, benign bony tumor of the distal phalanx. It occurs mainly in the great toe and less frequently in the other toes and fingers. It may cause nail deformity and pain. Objective: We wanted to describe the clinical, histopathological and radiological features and the recurrence after treatment of subungual exostosis. Methods: A total of 12 patients who were diagnosed with subungual exostosis at our hospital from 1997 through 2007 were evaluated. Results: There were seven females and five males. The average age of the patients at the time of surgery was 24.2±9.2 years. The mean duration of symptoms was 11±6.0 months. All the patients presented with a solitary, fixed, hard exophytic tumor beneath the nail plate. Eight patients (67%) presented with a lesion on the great toe, three patients (25%) with a lesion on the other toes and one patient (8%) with a lesion on the thumb. The histopathology revealed a fibrocartilaginous cap, enchondral ossification and calcification in all the patients and islands of mature trabecular bone in ten patients (83%). The radiographic picture showed a typical pattern of a bony excrescence arising from the dorsal aspect of the distal phalanx. All the patients were treated with surgical excision of the lesion and eleven patients (92%) showed good results. One patient (8%) had a local recurrence and she underwent subsequent excision. No additional local recurrences were observed. Conclusion: Subungual exostosis is unfamiliar to most dermatologists, and it can be difficult to diagnose in some cases. When a subungual mass is observed, subungual exostosis should be considered in the differential diagnosis and subsequent radiographic studies along with histologic studies are recommended. (Korean J Dermatol 2009; 47(1):43~49)

Skin & intestinal microbiomes in psoriasis

정기헌 ( Ki-heon Jeong ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Skin diseases affected by UV radiation

정기헌 ( Ki Heon Jeong ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.73 No.2

Fast and long lasting response with secukinumab: RCTs to RWEs

정기헌 ( Ki Heon Jeong ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2

Usage of biologics increased recently as diverse biologics were launched, including IL-17 inhibitors and IL-23 inhibitors. As a result, psoriasis treatment has more option than before, and patients can easily reach clear skin, even aiming for further benefits of biologics. However, most of the clinical trials done with biologics is randomized clinical trials. Since Randomized clinical trials are designed to exclude bias, there are limitations that cannot reflect the real world practice. In fact, specific treatments fail to reach the efficacy that they shown in the clinical trials in real world practice. Hence, the importance of real world trial has been increasing. Also in the psoriasis treatment, referring to both RCT and RWE may provide various angles to review the efficacy and safety of the biologics.

Frontal Fibrosing Alopecia 7예에 대한 고찰

정기헌 ( Ki Heon Jeong ),유박린 ( Bark Lynn Lew ),심우영 ( Woo Young Sim ) 대한피부과학회 2008 大韓皮膚科學會誌 Vol.46 No.4

Background: Frontal fibrosing alopecia (FFA), typically observed in elderly women, is characterized by a band of frontal or frontoparietal hair recession with scarring and a marked decrease, or a complete loss of the eyebrows. Objective: To describe the clinical and histopathological features, and response to treatment of FFA in Korean patients. Methods: A total of 7 female patients, diagnosed as FFA at our department from 2003 through 2006, were evaluated. Results: All patients presented with a band of symmetric recession of the frontoparietal hairline. Four patients (57.1%) had symmetric loss of lateral eyebrows. Two patients (28.6%) were premenopausal. The histologic features were similar in all patients with a reduction of the number of hair follicles, and a perifollicular lymphocytic infiltration with lamellar fibrosis limited to the upper portions of the follicles. The progression of the condition stopped in all patients after topical steroid treatment. Conclusion: Cases of FFA affected in premenopausal female patients drove us to consider that this condition is not exclusive to postmenopausal females. To make a diagnosis of FFA, we should remind ourselves of the typical clinical and pathologic features. Further studies are necessary to confirm the possible role of treatment in FFA and stop the progression in the early stages of FFA. (Korean J Dermatol 2008;46(4):459~464)

수력발전소 동기차단기 국산화 개발

김종우(Jong-Woo Kim),정기헌(Ki-Heon Jeong),김시종(Sy-Jong Kim) 대한전기학회 2023 대한전기학회 학술대회 논문집 Vol.2023 No.7