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복수의 성상을 감별 진단함에 있어서 복수의 지질 , 혈청과 복수의 Albumin 농도비 , LDH 동위효소 및 복수내 Fibronectin 치의 의의
이인홍(In Hong Lee),윤인혁(In Hyuk Yoon),전재범(Je Bum Chun),함준수(Joon Soo Hahm),이종철(Jong Chul Lee),이민호(Min Ho Lee),이동후(Dong Hoo Lee),박경남(Kyung Nam Park),기춘석(Choon Suhk Kee) 대한내과학회 1992 대한내과학회지 Vol.43 No.3
N/A Background: There are many parameters available to differentiate between malignant and non-malignant acsites. We studied the diagnostic value of ascitic lipid, LDH isoenzymes, serum ascites albumin gradient ratio and fibronectin levels to differentiate between malignant & non-malignant ascites. Methods: 51patients with ascites (21cirrhosis, 2nephrotic syndrome 17, various neoplasms and 11both cirrhosis & hepatocellular carcinoma) were studied to evaluate the diagnostic value of above mentioned 4parameters. Results; 1) Above mentioned 4parameters are statistically very significantly different between malignant and non- malignant ascites than previous parameters. 2) Total ascitci LDH levels ard LDH and LDH levels are markedly high in malignant ascites than LDH and LDH levels. 3) The median and mean values of cholesterol, triglycerides, phospholipids and total lipids were significantly high in malignant specificity of ascitic cholesterol in the differentiation between malignant ascites and benign ascites were 82% and 100% respectively as a cut off value of ascites cholesterol is 42mg/dl. 4) Serum ascites albumin gradient ratio in malignant ascites (0.88±0.62) and benign ascites (4.77±1.250) showed signifacantly difference, and diagnostic sensitivity and specificity are 80% and 100% as a cut off value is less than 1.1. 5) Ascitic Fibronectin levels are significantly high in malignant ascites (116±75 mg/1) than benign ascites (32±21mg/1). Its diagnostic sensitivity-and specificity are 61% and 96% as a cut off value is over 85mg/l. Conclusion; Above 4 parameters ard statistically significant to differenciate between malignant and non- malignant ascites, especially serum ascites albumin gradient ratio and ascitic lipids levels are more valuable for the differential diagnosis of ascites.
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