음핵에 발생한 원발성 편평 세포암

김대영 ( Dae Young Kim ),이승철 ( Seung Chul Lee ),정진욱 ( Jin Wook Jung ),원영호 ( Young Ho Won ),전인기 ( Inn Ki Chun ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1

Primary carcinoma of the vulva is predominantly a disease of elderly women, a somewhat infrequent entity, accounting for approximately 3-4% of all female genital cancer and less than 1% of all malignant disease. Many studies have pointed out the long delay in the diagnosis of the cancer. This is due not only to the reluctance of the older patient to seek attention for this personal problem, but to the delay of the physician in taking a biopsy. Therefore physicians should carry out a biopsy in every patient when the diagnosis is uncertain or the lesion fails to resolve with topical therapy. We experienced a case of squamous cell carcinoma arising from the clitoris in 65 years old woman. She had had a pruritic erythematous patch on the external genitals for 20 years but never visited a clinic. One month before, she found a reddish papule on the clitoris which enlarged rapidly and reached a exophytic hard 1.5 * 2.1 cm sized mass. The patient was treated with a radical vulvectomy and bilateral lymph nodes dissection of the groin with oophorectomy. She had been followed for 20 months without any evidence of recurrence. (Kor J Dermatol 1996;34(1): 171-175)

요도 개구부 주위에 발생한 Queyrat 홍색비후증

권병대(Byung Dae Kwun),김성진(Seong Jin Kim),원영호(Young Ho Won),전인기(Inn Ki Chun) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.1

Erythroplasia of Queyrat is an uncommon form of carcinoma in situ involving the glans penis and adjacent mucosal structures. Treatment modalities of Erythroplasia of Queyrat vary widely and topical 5-fluorouracil treatment is very effective and regarded as the choice of t eatment. This article reports a case of erythroplasia of Queyrat involving the perimeatal region of the glans penis and identifies the difficulty of effectively treating erythroplasia of Queyrat which is adjaer to the urethral meatus with 5-fluorouracil and usefulness of electron beam irradiation therapy. (Kor J Dermatol 1994; 32(1): 153-157)

피부표면지질의 분석에 의한 연령병 피지선 활동도 변화에 관한 연구

권병대(Byung Dae Kwun),원영호(Young Ho Won),김영표(Young Pio Kim),전인기(Inn Ki Chun) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.6

Background: The human sebaceous glands have long been known to change their activity with aging. Downing and his co-workers state that the ratio of wax ester/cholesterol+cholesterol ester in the skin surface lipids might be a good index for sebaceous gland acti ity. Objective : Our purpose was to evaluate the effects of aging on the sebaceous gland activity and relative skin surface lipid composition by using thin layer chromatography. Methods : Skin surface lipids of anterior chest from 65 healthy Korean indivisuals were collected by using the cup method. Skin surface lipid were separated and meaurd by thin layer chromatographic analysis. Results : The sebaceous gland activity, vrhich was expressed by tlie ratio wax ester/[cholesterol+cholesterol ester] showed a ilistinct change from infancy to senescenc. The curve of the ratio makes a peak in the third decade and decreases with advancing age. Conclusion : This result disclosed that sebaceous gland activity iaifected by advancing age in Koreans and can be used as one of the biologic markers of aging. (Kor J Dermatol 1993;31(6):912-919)

골수섬유증과 관련된 양측 수부의 괴저성 농피증

김대영,원영호,김성진,이승철,전인기 ( Dae Young Kim,Young Ho Won,Seong Jin Kim,Seung Chul Lee,Inn Ki Chun ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4

Pyoderma gangrenosum is a rare neutrophilic dermatosis manifesting as painful pustules or bullae, which rapidly become necrotic to produce an ulceration. It is often associated with systemic disease, such as inflammatory bowel disease, rheumatoid arthritis, leukemia, but myelofibrosis is reported rarely for its underlying disease. The most common location is the lower extremities, and the pyoderma gangrenosum also occur infrequently on the hand and face. As in our case, bilateral involvement of the hands are rarely reported. We present a case of pyoderma gangrenosum that had developed on both hands in a 66 year old man who had macrocytic,anemia. A bone marrow biopsy revealed proliferation of fibroblasts and a dense reticulin network consistent with myelofibrosis, the association of which is very rare world wide. (Kor J Dermatol 1997;35(4): 809-813)

한공각화증 79예에 대한 임상 및 병리조직학적 연구

원영호,김대영,김성진,전인기 ( Young Ho Won,Dae Young Kim,Seong Jin Kim,Inn Ki Chun ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.1

Background: Porokeratosis is a rare disorder characterized by an abnormal keratinization. Five different clinical types have been described, however most reports are on a small scale and rest,ricted to a particular type. Objective : We tried to distinguish clinical and histopathologi'cal feat.ures of each type of porokeratosis. Methods: All patients with porokeratosis visiting the Dermatological Department of Chonnam University Hospital were retrospectively reviewed and finally 79 patients were evaluated. Results . Disseminated superficial actinic porokeratosis(DSAP) was most common it was present in 44 patients(56%). This was f'ollowed by the plaque type(28%), linear type(14%) and punctate type(2%). The:;oungest average age of onset was in the linear type at 13 years old (range 2-34 years old), and the oldest in DSAP which appeared in all patients after the age of 20. The plaque type was predominant in males 2.6 times rnore than in females. The predilection sites were the trunk in the plaque type, the unilateral lower limbs in the linear type and the face lower limbs in DSAP. 1tching was a complaint in 71% of DSAP and pain was in 14% of t.he plaque type. DSAP revealed a family history in 23% and a solar exacervation in 41%. Three cases of the plaque type t ad a malignant change. The average number of cornoid lamella per section was 1.8(ranging from one to seven). The height and invagination depth of cornoid lamellae were most prominent in the plaque type, and the le~ast in DSAP. Dysk(ratotic cells and vacuolar cell degenerat,ion in t.he underlying epidermis were most frequent in the plaque type. However dermal melanophage were present in DSAP. The Epidermis inside ring of:o~rnoid lamella was acanthotic chiefly in the plague type and atrophic chiefly in DSAP. Conclusion : These resuts demonstrate that each type of porokeratosis is somewhat, different in clinical and histopathological features. (Kor J Dermatol 1997;35(1): 33-40)

악성 섬유성 조직구종

김성진(Seong Jin Kim),권병대(Byung Dae Kwun),원영호(Young Ho Won),전인기(Inn Ki Chun) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.4

The malignant fibrous histiocytoma is a predominantly pleomorphic arcoma usually occuring in the deep soft tissue of adults. Because of its highly variable morphologic pattern, this tumor has often been confused with other sarcomas such as pleomorphic rhabdomyosarcoma and liposarcoma. Although the histogenesis of this neoplasm remains controversial, it is best regarded as a primitive and pleomorphic nature reflected by collagen production and occasional phagocytosis. As report a case of malignant fibrous histiocytoma occurring in a 54-year-old female who presented with 4.5 x 5 x 0.5cm sized mass on the right thigh and metastasis later. Histopathologic findings shows plamp spindle cells appearing in a storiform-pleomorphic pattern around slitlike vessels. Immunohistochemical staining and electron microscopic findings led to the final diagnosis as malignant fibrous histiocytoma. The treatment was surgical excision. (Kor J Dermstol 1993;31(4):649-854)

자매에서 발생한 전신성 홍반성 루푸스 2예

박종혁,조대영,김성진,이승철,원영호,전인기 ( Jong Hyuk Park,Dae Young Cho,Seong Jin Kim,Seung Chul Lee,Young Ho Won,Inn Ki Chun ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6

The pathogenesis of systemic lupus erythematosus (SLE) appears to be multifactorial, including both genetic and environmental influences. The genetic factor of SLE is well known to have an important role in the pathogenesis based on epidemiological analysis and studies of monozygotic twins. The disease occur. more commonly in first degree relatives and may affect multiple persons in single families. We report a family in which two sisters developed systernic lupus erythematosus. The clinical, laboratory and histopat,hological findings showed characteristic features of systemic lupus erythematosus. HLA testing revealed that the two sisters shared common HLA-DR15(2)and HLA-A2. (Korean J Dermatol 1997;35(6): 1220-1224)