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임미혜,박종혁,이승철,원영호,전인기 ( Mi Hae Lim,Jong Hyuk Park,Seung Chul Lee,Yong Ho Won,Inn Ki Chun ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1
Lichen planopilaris is believed to be a variant of lichen planus which is occasionally accompanied by classical lichen planus. A 68-year old male had asymptomatic skin colored or light violet colored papules and nodules on the occipital area followed by hair loss for 2 months. He had also violaceous pea to bean sized whitish scaly papules on the right lower extremity. Histopathological examination revealed the dilated follicles to be filled with horny material. There were also intense infiltrations of monocytes which were most prominent at the lower pole of the hair follicles on the scalp lesion. There was also hyperkeratosis, focal hypergranulosis and band-like infiltrations of lymphocytes at the dermo-epidermal junction on the lesion of the lower extremity. Direct immunofluorescence examination showed linear deposition of fibrin at the dermo-epidermal junction in the hair follicles. We had an opportunity to observe a man with lichen planopilaris who had loss of scalp hair which was accompanied by classical lichen planus on the lower extremity. (Kor J Dermatol 1997;35(1): 139-143)
편평 사마귀에 대한 DNCB와 DPCP 면역요법의 치료 효과에 대한 비교 연구
박종혁,김성진,이승철,원영호,전인기 ( Jong Hyuk Park,Seong Jin Kim,Seung Chul Lee,Young Ho Won,Inn Ki Chun ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6
This stuc1y was conducted to evaluate the therapeutic effect of immunotherapy on verruca plana. Forty-four patients with verruca plana were tried with dinitrochlorobenzene(DNCB) and diphenylcyclopropenone(DPCP) by topical application on the norinal uninvolved skin of the inner arms for sensitization and challenge. The lesions were challenged in weekly intervals after sensitization. The results obtained in this study are as follows. 1. Mean age of our patients was 20-year-old and sex ratio was about 1:2 (14 of male, 30 of female). 2. Tbe sites of the lesion weve face (60.9%), neck (7.2%), trunk (2.9%), arm (li3.0%), hand (11.6% ), leg (4.3% ). 3. Thirty two patients (72.7%) from 44 cases were completely cured after DNCB (81.3%) and DPCP (67%) treatment and iesions on younger patients showed a better response than those of of older patients(p<0.05). 4. There were no statistic relationship between duration of the lesions and therapeutic response. 5. Average challenge number after sensitization was 3.77 in DNCB, 2.26 in DPCP, respectively. 6. Sensitization rates in the cured patients were to treat verruca plana 94.7% (18/19) in DNCB, 76.9% (10/13) in DPCP, respectively. (Korean J Dermatol 1997;35(6): 1082-1087)
박종혁,조대영,김성진,이승철,원영호,전인기 ( Jong Hyuk Park,Dae Young Cho,Seong Jin Kim,Seung Chul Lee,Young Ho Won,Inn Ki Chun ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6
The pathogenesis of systemic lupus erythematosus (SLE) appears to be multifactorial, including both genetic and environmental influences. The genetic factor of SLE is well known to have an important role in the pathogenesis based on epidemiological analysis and studies of monozygotic twins. The disease occur. more commonly in first degree relatives and may affect multiple persons in single families. We report a family in which two sisters developed systernic lupus erythematosus. The clinical, laboratory and histopat,hological findings showed characteristic features of systemic lupus erythematosus. HLA testing revealed that the two sisters shared common HLA-DR15(2)and HLA-A2. (Korean J Dermatol 1997;35(6): 1220-1224)