談談文化因素在漢語敎學中的地位和作用

전계민 충남대학교 인문과학연구소 1998 인문학연구 Vol.25 No.1

천수신경조절술에 대한 반응도로 본 영향인자의 단기적 분석

전계민,윤하나 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.2

Purpose: Sacral neuromodulation has become an effective option for controlling intractable symptoms of overactive bladder: urgency and urge incontinence. However, it has its limitations in that an intermittent pulse generator (IPG) is insertable only in patients with symptom improvement of at least 50%. In this study, we aimed to investigate the parameters that predict surgical outcomes. Materials and Methods: Data from 31 candidates for sacral neuromodulation were retrospectively analyzed. Twenty patients out of 31 candidates had satisfactory symptom improvement after tinned lead test implantation, which resulted in IPG implantation. Data and neural stimulation parameters were compared and analyzed between successful IPG implants (group 1) and test failures (group 2). Results: The percentage of female patients was higher in the IPG implant group (group 1: 95%, group 2: 64%). There was a significant difference in symptom duration, between the two groups (group 1: 40.5 months, group 2: 91 months). There was a significant difference in the number of episodes of urgency between the two groups (group 1: 6.83/day, group 2: 9.66/day, p=0.012), and severity of urgency showed significant difference between two groups (group 1<group 2, p=0.027). Conclusions: In females, the severity and duration of symptoms may be factors predicting poor response to neuromodulation. Although there is a need for further data analysis, this study suggests that the proper selection of surgical time is important in controlling patients’ lower urinary tract symptoms by neuromodulation. Purpose: Sacral neuromodulation has become an effective option for controlling intractable symptoms of overactive bladder: urgency and urge incontinence. However, it has its limitations in that an intermittent pulse generator (IPG) is insertable only in patients with symptom improvement of at least 50%. In this study, we aimed to investigate the parameters that predict surgical outcomes. Materials and Methods: Data from 31 candidates for sacral neuromodulation were retrospectively analyzed. Twenty patients out of 31 candidates had satisfactory symptom improvement after tinned lead test implantation, which resulted in IPG implantation. Data and neural stimulation parameters were compared and analyzed between successful IPG implants (group 1) and test failures (group 2). Results: The percentage of female patients was higher in the IPG implant group (group 1: 95%, group 2: 64%). There was a significant difference in symptom duration, between the two groups (group 1: 40.5 months, group 2: 91 months). There was a significant difference in the number of episodes of urgency between the two groups (group 1: 6.83/day, group 2: 9.66/day, p=0.012), and severity of urgency showed significant difference between two groups (group 1<group 2, p=0.027). Conclusions: In females, the severity and duration of symptoms may be factors predicting poor response to neuromodulation. Although there is a need for further data analysis, this study suggests that the proper selection of surgical time is important in controlling patients’ lower urinary tract symptoms by neuromodulation.

Effect of Stress on the Expression of Rho-Kinase and Collagen in Rat Bladder Tissue

윤하나,이동현,전계민,윤현석,유재영 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.2

Purpose: We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation. Materials and Methods: A total of 48 female Sprague-Dawley rats were studied in scheduled stress environments for 7, 14, and 28 days; 24 rats were in the control group and 24 rats were in the test (stressed) group. Results: Estrogen decreased significantly whereas testosterone and dopamine increased significantly in the stress group (p<0.05). Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p<0.05). Collagen types I and III in the bladder tissue were significantly higher in rats exposed to stress for 14 days and 28 days (collagen type I in the 14-day group, p<0.01; collagen type I in the 28-day group, p<0.05; collagen type III in the 14-day and 28-day groups, p<0.05). Voiding frequency increased significantly as the duration of stress exposure was prolonged, in addition to a significant decrease in volume per voiding (p<0.05). Conclusions: The changes observed in micturition pattern, factors that contribute to smooth muscle contraction, and relaxation in the female rat bladder support the hypothesis that stress affects bladder stability. Purpose: We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation. Materials and Methods: A total of 48 female Sprague-Dawley rats were studied in scheduled stress environments for 7, 14, and 28 days; 24 rats were in the control group and 24 rats were in the test (stressed) group. Results: Estrogen decreased significantly whereas testosterone and dopamine increased significantly in the stress group (p<0.05). Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p<0.05). Collagen types I and III in the bladder tissue were significantly higher in rats exposed to stress for 14 days and 28 days (collagen type I in the 14-day group, p<0.01; collagen type I in the 28-day group, p<0.05; collagen type III in the 14-day and 28-day groups, p<0.05). Voiding frequency increased significantly as the duration of stress exposure was prolonged, in addition to a significant decrease in volume per voiding (p<0.05). Conclusions: The changes observed in micturition pattern, factors that contribute to smooth muscle contraction, and relaxation in the female rat bladder support the hypothesis that stress affects bladder stability.

음경배부신경절제술의 합병증으로 발생한 음경해면체류

윤현석,유재영,전계민,구진모,유석선,정우식 대한남성과학회 2010 The World Journal of Men's Health Vol.28 No.1

A 43-year-old man presented painless protruding mass on left side of penile shaft only during erection. 1 year ago he had a dorsal penile neurectomy for the treatment of premature ejaculation at local clinic. A protruding cavernousal aneurysm about 2 cm in diameter was developed 6 months after surgery and confirmed on penile duplex ultrasonography after PDE5 inhibitor ingestion with visual sexual stimulation. We have observed the lesion every month and found there was slight enlargement for the last 3 months without any other symptoms. We performed cavernosoplasty under the genereal anesthesia. There was a round cavernosal aneurysm on the left side of penile mid-shaft about 4cm in diameter after artificial erection with intracavernosal saline injection. We prevented cavernosal protrusion by covering the aneurismal surface with bovine pericardium patch (Supple Peri-GuardⓇ). There was no side effect for 6 months postoperatively. This is an unusual type of complication of dorsal penile neurectomy.

여성 하부 요로 증상과 외음부 진동감각 역치의 상관관계

유재영,윤현석,전계민,윤하나 이화여자대학교 의과대학 2009 EMJ (Ewha medical journal) Vol.32 No.1

Purpose:Biothesiometer is a device for quantitatively measuring vibratory thresholds in a noninvasive manner. It has been utilized for evaluating variety of neurological diseases for decades. We aimed to investigate difference of vibratory thresholds according to presence of specific lower urinary tract symptoms(LUTS). Materials and Methods:173 female patients were included in this study. We investigated medical history, and performed physical examination, cystoscopy, and biothesiometry. Biothesiometry were recorded on clitoris, vestibules, and both labia minora. Relationship between age, LUTS, serum triglyceride(TG) and cholesterol(Chol) level, and vibratory thresholds were also analyzed. Results:Mean age of patients was 51.8±9.4 years. LUTS consisted of stress urinary incontinence(SUI)(87.4%), urgency or urge incontinence(UUI)(77.1%), and frequency(66%). Age was closely related with vibratory thresholds. Correlation coefficient was 0.394, 0.343, 0.332, 0.294, 0.279 for clitoris, both labia, and anterior and posterior vestibules, respectively(p<0.001). Patients with SUI and UUI showed significantly increased vibratory thresholds on clitoris and right labium compared to those who do not have any of SUI or UUI(p<0.05). TG and Chol levels were not related with vibratory thresholds. Conclusion:Vibratory thresholds of external genitalia area were increased in proportion to age. Patients had different vibratory thresholds according to their LUTS. This finding suggests that LUTS is associated with insufficiency of pudendal nerve.