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이미경(Mi Kyung Lee),임승길(Sung Kil Lim),이현철(Hyun Chul Lee),허갑범(Kap Bum Huh),장상섭(Sang Sub Chung),이규창(Kyu Chang Lee),박기현(Ki Hyun Park),박찬규(Chan Kyu Park) 대한내과학회 1988 대한내과학회지 Vol.35 No.2
N/A Hyperprolactinmia is a relatively common clinical problem occurring in more than 25 percent of women who have secondary amenorrhea. Previous studies of hyperprolactinomic women suggested an association with decreased cortical bone density. To determine whether hyperprolactinemia is associated with reduced bone mineral density, we measured the bone mineral density of the vertebrae, femoral neck, and Ward's Triangle by dual photon absorptiometry in 18 hyper-prolactinemic patients, The bone mineral density for each patient fell almost within ±2 standard deviations of the mean for the decade-matched normal subjects. The prevalence of osteoporosis was 28% in hyperprolactinemic patients. The mean duration of amenorrhea in patients with osteoporosis was significantly longer than that in patients without oseteoprosis, 10±5 year, 5±6year, respectively (p<0.05). The mean estradiol level was not significatly different between the oteoporotic and nonoteoporotic groups. There was no significant difference in the pitutiary reserve function between the osteoporotic and non-oseoportoic groups, In patients who under- went surgery, radiotherapy and treatment with bromocryptine, the bone mineral density was relatively lower than that of patients treated by surgery and bromocryptine, or bromocryptine only. It is concluded that hyperprolactinemia is associated with reduced bone mioeral density, which is inversely related to the mean duration of amenorrhea.
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