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김성주 ( Sung Joo Kim ),김창모 ( Chang Mo Kim ),김범 ( Bum Kim ),장기택 ( Kee Taek Jang ),강정배 ( Jung Bae Kang ),장봉림 ( Pong Rheem Jang ),손우석 ( Woo Seok Sohn ),민봉식 ( Bong Sik Min ) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
Aggressive angiomyxoma is a rare pathological condition which affects mainly the soft tissues of the pelvis and perineum in women. It is circumscribed totally or partially and has a infiltrative margin, so it has a tendency for local recurrence. We report a 33-year-old woman who presented with a mass arising within the vaginal wall which was painless, soft and movable like a cyst on palpation. The mass was surgically excised and pathologically proved to be an aggressive angiomyxoma.
임신 1 삼분기중 Nuchal Translucency 와 free β-hCG , PPP -A 를 이용한 염색체 이상진단의 선별검사로서의 유용성
김성주(Sung Joo Kim),민봉식(Bong Sik Min),김창모(Chang Mo Kim),손우석(Woo Seok Sohn),강정배(Jung Bae Kang),장봉림(Pong Rheem Jang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.6
N/A Objectives: The aim of this study is to determine the efficacy of nuchal translucency in combination with free β-hCG, PAPP-A in the first trimester screening for chromosomal anomaly in general population. Methods: Between April 1998 and December 1999, we evaluated 263 pregnant women undergoing first trimester screening test for fetal chromosomal anomaly using nuchal translucency combined with free β -hCG, PAPP-A. We confirmed the pregnancy outcomes through chorionic villi sampling, amniocentesis or term delivery. We excluded 15 pregnant women because of their obscure pregnancy outcomes. Statistical analysis w; considered significant when P value was lower than 0.05. Results: With a risk cut-off of 1 in 400, 24 pregnancies(9.7%) of 248 cases were screen positive and 224 pregnancies(90.3%) were screen negative. 2 cases of Down syndrome and 1 case of Tumer syndrome were detected in screen positive group. No chromosomal anomalies were detected in screen negative group. Conclusion: In this study, 8.57% of false positive rate and 12.5% of positive predictive value were obtained in the first trimester screening for chromosomal anomaly using nuchal translucency and serum markers.
난소종양에서 Cyclooxygenase - 2 의 발현
손우석(Woo Seok Sohn),민봉식(Bong Sik Min),김창모(Chang Mo Kim),김성주(Sung Joo Kim),강정배(Jung Bae Kang),박혜림(Hye Rim Park),장봉림(Pong Rheem Jang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
N/A Objective: A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in tumorigenesis of gastrointestinal and other cancers. This was the study to determine whether COX-2 was also expressed in benign and malignant ovarian tumors. Methods: We studied the expression of COX-2 in various ovarian tumors [ Benign epithelial tumors (n=10), borderline epithelial tumors (n=12), malignant epithelial tumor (n=12), nonepithelial tumors(n=10) ] by immunohistochemistry. Results of immunoreactivity was classified semiquantitatively based on the proportion and intensity of tumor cell immunostaining. Results: In the epithelial ovarian tumors, the intensity of immunostaining was stronger in the malignant tumors than the benign and borderline tumors (p<0.001). Especially all serous and mucinous malignant tumors (n=9) showed weak and strong immunoreactivity, with 66.7% strong reactivity. None of the nonepithelial ovarian tumors expressed COX-2 immunoreactivity. Conclusion: These preliminary data indicate that COX-2 may have a role in carcinogenesis of epithelial ovarian tums, especially in the serous and mucinous types. COX-2 maybe a target for future research in the tumorigenesis of the epithelial ovarian malignancies.
최정운 ( Jung Un Choi ),윤근영 ( Keun Young Yoon ),한정미 ( Jung Mi Han ),정윤아 ( Yoon A Jung ),임채춘 ( Chae Chun Rhim ),김성주 ( Seong Ju Kim ),박영한 ( Young Han Park ),강정배 ( Jung Bae Kang ),장봉림 ( Pong Rheem Chang ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.11
Hyperemesis gravidarum is a complication defined as nausea and vomiting during early pregnancy. Atypical hyperemesis syndrome is caused any other problems. Specially, brain tumors is confused hyperemetic symptom in pregnancy. In this case vomiting and mild headache were the only signs. Atypical hyperemesis syndrome is recommand MRI image study for detection of neurologic problem. Following the diagnosis of a brain tumor during pregnancy and management should be tailored to the individual patient. It must be considered to maternal state and fetal maturation. To minimize cerebral herniation in neurologically unstable patient, a consideration should be made for cesarean section delivery with patient under general anesthesia.