http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 임주혁(Joo Hyuck Im) (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
[ I - 123 ] IPT SPECT를 이용한 도파민 재섭취부위의 영상화 : 반정성적 분석방법을 이용한 정상인과 파킨슨병 환자의 차이
양승오(Seoung Oh Yang),최윤영(Yun Young Choi),이희경(Hee Kyung Lee),김희중(Hee Joung Kim),류진숙(Jin Sook Ryu),임주혁(Joo Hyuck Im),이명종(Myung Chong Lee) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.1
N/A Dopamine transporter concentrations have been known to decrease in Parkinson's disease (PD) or increase in Tourette's disorder. The purpose of this study was to evaluate the effectiveness of [I-123]N-(3-iodopropene-2-yl)-2β-carbomethoxy-3β-(4-chlorophenyl) tropane (IPT) as an imaging agent for measuring changes in transporter concentrations with PD. IPT labelled with 6.69+/-0.64 mCi (247.53+/-23.68 MBq) of I-123 was intravenously injected into ten patients(age: 55+/-11) with PD, and six normal controls(NC)(age: 46+/-14) as a bolus. Dynamic SPECT scans of the brain were then performed for 5 minutes each over 120 minutes on a triple headed camera. Time activity curves were generated for the left basal ganglia(LBG), right basal ganglia(RBG), and occipital cortex(OCC). The statistical parameters included the time to peak activity, the contrast ratio of LEG and RBG to OCC at several time points, and the accumulated specific binding counts/mCi/pixel (ASBC) from 0 to 115 minutes. The uptake of IPT in the brains of PD and NC peaked within 10 minutes of injection in all subjects. The maximum target to background ratio in the basal ganglia of PD and NC occurred at 85+/-20 min and 110-+/-6 min of injection, respectively. The BG/OCC ratios at 115 minutes for PD and NC were 2.15+/-0.54 and 4.26+/-0.73, respectively. The ASBC at 115 minutes for PD and NC were 152.91+/-50.09 and 289.51+/-49.00, respectively. The ratio of BG/OCC for the NC was significantly higher than the ratio for PD. SPECT data matched with clinical diagnosis for PDs. The ratio between BG and OCC and the ASBC for PD were clearly separated from NC and may be useful outcome measures for clinical diagnosis. The findings suggest that IPT may be a very useful tracer for early diagnosis of PD and study of dopamine reuptake site.
-
[ I - 123 ] IPT SPECt를 이용한 정상인과 파킨슨환자의 도파민 운반체의 영상화 및 단순화된 정량분석 방법들의 비교연구
문대혁(Dae Hyuk Moon),양승오(Seoung Oh Yang),이희경(Hee Kyung Lee),김희중(Hee Joung Kim),류진숙(Jin Sook Ryu),천준홍(Jun Hong Cheon),임주혁(Joo Hyuck Im),봉정균(Jung Kyun Bong),남기표(Ki Pyo Nam),권수일(Soo Il Kwon) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.3
N/A The purpose of this study was to compare the specific binding ratio method with model based methods in estimating the transporter parameter k3/k4 in normal controls and Parkinson's patients with [I-123]IPT SPECT and to evaluate the usefulness of [I-123]IPT SPECT. 6.5±1.1 mCi (239.0±40.3 MBq) of [123]IPT was intravenouly injected as a bolus into six normal controls(age:45±13) and seventeen patients(age:55±8) with Pakinson's disease(PD). The transporter parameter k3/k4 was derived using the Ichise's graphical method(Rv) and Lassen's area ratio method(RA) for the dynamic IPT SPECT data without blood samples. Then, the relationships between the transporter parameter Rv, RA and the ratio of (BG-OCC)/OCC at 115 minutes were evaluated by linear regression analysis. Rvs by Ichise's graphical method for NC and PD were 2.08±0.29 and 0.78±0.31, respectively. RAs by Lassen's area ratio method for NC and PD were 1.48±0.16 and 0.65±0.24, respectively. The correlation coefficients between (BG-OCC)/OCC and Rv, (BG-OCC)/OCC and RA, and RV, and RA were 0.93, 0.90, 0.99 and their corresponding slopes were 0.54, 0.34, and 0.65,respectively. The Rv and RA of NC were significantly higher than the ones of PD. That is, the k3/k4 Of NC was clearly separated from the one of PD. k3/k4 showed a good correlation with the ratio of (BG-OCC)/OCC. The results indicate that the noninvasive simplified quantitative methods may be useful to measure the transporter parameter k3/k4 and the specific binding ratio method can be used for quantitative studies of dopamine transporter with [I-123]IPT SPECT in humans brains.
-
최은정,방현,임주혁,이재홍 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1
Extrapyramidal signs (EPSs) frequently accompany Alzheimer's disease(AD). However, the pathogenesis or pathologic basis for the EPSs in AD remains unclear. We report a case of presenile onset progressive dementia later associated with hemiparkinsonism. Brain biopsy showed neurofibrillary tangles and amyloid plaques. compatible with Alzheimer's disease. There are a few report about dopamine transporter imaging of AD with EPSs. 1-123 IPT SPECT revealed a decreased uptake in both basal ganglia, more severe on the left side and in the caudal putamen, which is consistent with the finding of idiopathic Parkinson's disease. Alzheimer's disease and Parkinson's disease are thought to be coexistent in our patient.
ScienceON
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
