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윌슨씨병으로 진단된 138예-new phenotypic classification
김인숙 ( Kim In Sook ),이영상 ( Lee Yeong Sang ),장명국 ( Jang Myeong Gug ),최원범 ( Choe Won Beom ),김성훈 ( Kim Seong Hun ),임영석 ( Im Yeong Seog ),이한주 ( Lee Han Ju ),정영화 ( Jeong Yeong Hwa ),서동진 ( Seo Dong Jin ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 상염색체 열성으로 유전되며 1:30,000의 발병률을 가진 윌슨씨병에 대해 본원에서 진단된 환자의 구체적 임상양상을 고찰해보고, liver international (Ferenci P et al, 23, 2003)과 hepatology (Roberts EA et al, 37, 2003)에서 새로이 정립한 hepatic wilson환자에 대한 분류를 사용하여 보고자 한다. <대상 및 방법> 환자군은 본원에서 윌슨씨병으로 진단된 138예를 대상으로
정준오 ( Jeong Jun O ),곽금연 ( Gwag Geum Yeon ),임영석 ( Im Yeong Seog ),김정룡 ( Kim Jeong Lyong ),이효석 ( Lee Hyo Seog ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2
Background/Aims: Hepatic stellate cells (HSCs) in the hepatocellular carcinoma are responsible for tumor encapsulation as a host defense mechanism. Recently, it was suggested that HSCs might play an important role in hepatic angiogenesis. Thus, HSCs in the HCC may be involved in tumor angiogenesis and pathogenesis of hepatic carcinogenesis. The purpose of this study was to examine the involvement of activated HSCs in the angiogenesis of hepatoma. Methods: We investigated the effect of human HSC conditioned medium (CM) on the endothelial cell proliferation with or without stimulation of HepG2 CM, using [3H] thymidine incorporation assay. Additionally, we investigated the effect of HepG2 CM on HSCs proliferation and messenger RNA (mRNA) expression of various pro-angiogenic factors such as interleukin 8 (IL-8), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in HSCs. Results: HSC CM caused a significant increase in DNA synthesis in human umbilical vein endothelial cells (HUVEC). The endothelial proliferation effect of HSCs was augmented by HepG2 CM. HepG2 CM significantly increased HSCs proliferation and stimulated IL-8 and bFGF mRNA expression in HSCs. Conclusions: HSCs promote endothelial proliferation through various soluble factors. The soluble factors secreted in HepG2 stimulate HSC proliferation and up-regulate mRNA expression of proangiogenic factors. This result suggests that HSCs may play an important role in the angiogenesis of hepatoma. (Korean J Gastroenterol 2003;42:142-148)