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최대성,김석호,임연묵,권희정,박종석,노영창,권중기 한국조직공학과 재생의학회 2012 조직공학과 재생의학 Vol.9 No.1
Proper wound management is an increasingly important clinical challenge and is a large and growing unmet need. Pressure ulcers, hard-to-heal wounds, and problematic surgical incisions are emerging with increasing frequency. At present, the wound-healing industry is experiencing a paradigm shift toward innovative treatments that exploit nanotechnology, biomaterials, and biologics. Here we determined the effectiveness of a radiation-processed hydrogel patch for the delivery of chestnut honey (CH) for the promotion of cutaneous wound healing in diabetic mice. CH is a natural compound that has antioxidant and bactericidal effects. Two full-thickness wounds were made on the dorsal side of diabetic (db/db) mice and the wounds were covered with hydrogel-incorporated CH. Time course observations revealed that mice treated with CH hydrogel showed accelerated wound closure and formation of granulated tissue, enhanced Ki-67 expression and early upregulated HO-1 proteins in the wound region compared with water hydrogel or non-treated mice. Taken together, these findings indicate that CH hydrogel can promote wound healing in diabetics with early HO-1 protein expression.
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신영민,정성인,권희정,정성인,임연묵,박종석 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.1
One of the interesting strategies for developingthe artificial blood vessels is to generate multi-layeredscaffolds for mimicking the structure of native blood vesselssuch as the intima, media, and adventitia. In this study, weprepared dual-layered poly(L-lactide-co-ε-caprolactone)(PLCL) scaffolds with micro- and nanofibers as a basicconstruct of the vessel using electrospinning methods,which was functionalized using a gelatin through acrylicacid (AAc) grafting by γ-ray irradiation. Based on themicrofibrous platform (fiber diameter 5 μm), the thicknessof the nanofibrous layer (fiber diameter 700 nm) wascontrolled from 1.1 ± 0.8 to 32.2 ± 1.7 μm, and the mechanicalproperty of the scaffolds was almost maintaineddespite the increase in thickness of the nanofibrous layer. The successful AAc graft by γ-ray irradiation could allowthe gelatin immobilization on the scaffolds. The proliferationof smooth muscle cells (SMC) on the scaffolds toward amicrofibrous layer was approximately 1.3-times greater thanin the other groups, and the infiltration was significantlyincreased, presenting a wide cell distribution in the crosssection. In addition, human umbilical vein endothelial cell(HUVEC) adhesion toward nanofibrous layer was wellmanagedover the entire surface, and the acceleratedproliferation was observed on the gelatin-functionalizedscaffolds presenting the well-organized gap-junctions. Therefore, our biomimetic dual-layered scaffolds may bethe alternative tools for replacing the damaged blood vessels.
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