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4,4''-Biphenol 유도체의 합성 및 충치균 Streptococcus mutans OMZ 176에 대한 항균작용
배기환(Ki Hwan Bae),서원준(Won Jun Seo),임승희(Seung Hee Leem) 대한약학회 1992 약학회지 Vol.36 No.1
In a continuous study for the developing of the anticariogenic agents, 3,3''-diacyl-4,4''-biphenol derivatives (Fig.2, 2 and 3) and 3,3''-bis-(1-hydroxyalkyl)-4,4''-biphenol (Fig. 3, 4 and 5) derivatives are synthesized successively from 4,4''-diphenol (Fig. 2, 1). The synthesized compounds are tested for their antibacterial activity against a cariogenic bacterium, Streptococcus mutans OMZ 176. The acyl derivatives, 2 and 3, do not show antibacterial activity, but the hydroxyallkyl derivatives, 4,and 5, reduced form the acyl group of 2 and 3, show the activity The antibacterial activity of 2 and 3 may be inhibited due to intramolecular hydrogen bonding between the acyl group and the hydroxyl one (Fig.4).
4,4'-Biphenol 유도체의 합성 및 충치균 Streptococcus mutans OMZ 176에 대한 항균작용
배기환,서원준,임승희 충남대학교 약학대학 의약품개발연구소 1992 藥學論文集 Vol.8 No.-
In a continuous study for the developing of the anticariogenic agents, 3,3'-diacyl-4,4'-biphenol derivatives (Fig.2, 2 and 3) and 3,3'-bis-(l-hydroxyalkyl)-4,4'-biphenol (Fig.3, 4 and 5) derivatives are synthesized successively from 4,4'-diphenol (Fig.2, l). The synthesized compounds are tested for their antibacterial activity against a cariogenic bacterium, Streptococcus mutans OMZ 176. The acyl derivatives, 2 and 3, do not show antibacterial activity, but the hydroxyalkyl derivatives, 4 and 5, reduced from the acyl group of 2 and 3, show the activity. The antibacterial activity of 2 and 3 may be inhibited due to intramolecular hydrogen bonding between the acyl group and the hydroxyl one (Fig.4).