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ATP-의존성 K+ Channel 차단제인 Gilbenclamide의 중추적 이뇨작용에 대한 신장 신경제거와 Cromakalim의 영향
고석태(Suk Tai Ko),임광남(Kwang Nam Ko),정경희(Kuong Hee Chung) 대한약학회 1999 약학회지 Vol.43 No.5
This study was performed to investigate the effect of renal denervation and cromakalim, a K+ channel opener, on central diuretic action of glibenclamide, an ATP-dependent K+ channel blocker, in dog. Diuretic action of glibenclamide administered into the vein was weakened markedly by renal denervation and pretreatment of cromakalim. Above results suggest that central diuretic action of glibenclamide is mediated by renal nerves and K+ channel localized in kidney.
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고석태(Suk Tai Ko),임광남(Kwang Nam Lim) 대한약학회 1994 약학회지 Vol.38 No.5
This study was performed in order to investigate the effect of diltiazem, which is a Ca2+ channel blocker of benzothiazepine derivatives, on renal function in the dog. Diltiazem, when infused into the vein or carotid artery, produced the antidiuresis accompanied with the decreased excretion rates of sodium and potassium in urine(ENa, EK) and the increased reabsorption rates of sodium and potassium in renal tubules(RNa, RK). Diltiazem, when infused into a renal artery, exhibited the diuresis along with the increased renal plasma flow(RPF), osmolar clearance(Cosm), ENa and EK, and decreased RNa and RK in only infused kidney. Above results suggest that diltiazem possess both antidiuretic action through central action and diuretic action by direct inhibition of electrolytes reabsorption rates in renal tubules, mainly distal tubule.
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ATP 의존성 K+ Channel 차단작용이 있는 Glibenclamide 가 개의 신장기능에 미치는 영향
고석태(Suk Tai Ko),임광남(Kwang Nam Yim) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.3
Glibenclamide(GLY)(1.0 and 3.0 mg/kg), an ATP-dependent K^+ channel blocker, when given into the vein in dogs, produced the diuretic action accompanied with the increase of osmolar clearance(C_(osm)), urinary excretion of Na^+ and K^+ (E_(Na+), E_K), and with the decrease in reabsorption rates for Na^+ and K^+ in renal tubules (R_(Na), R_K), and then ratios of K^+ against Na+ (K^+/Na^+) were decreased. GLY did not affect mean arterial pressure at any doses used. At a low dose(0.1 mg/kg), GLY injected into a renal artery brought about the diurectic action in both experimental and control kidney, however at a higher dose(0.3 mg/kg), GLY appeared significant diuretic action in the control kidney, but not in experimental kidney and the decrease of glomerular filtration rates(GFR), renal plasma flow(RPF), E_K, and the increase in E_(Na+). In the control kidney, these changes in renal function exhibited the same aspect as shown in intravenous experiments. In experiments given into carotid artery of GLY(0.5 and 1.5 mg/kg), changes in all renal function included the increase in urine volume were the same pattern as shown in intravenous experiments. The above results suggest that glibenclamide produces diuretic action through central function and the action site of the GLY in kidney is the renal distal tubules in dogs.
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腸機能에 關與하는 藥物의 作用에 對한 Verapamil의 影響
高錫太,鄭敬憙,任光楠 조선대학교 약학연구소 1994 藥學硏究誌 Vol.16 No.1
In ileum strips, verapamil did not influence the contractile action, inhibited the spontaneous movement to acetylcholine, verapamil inhibited both actions to pilocarpine and serotonin, and the contractile action but did not affect the spontaneous movement to histamine. In longitudinal muscle of colon, verapamil inhibited the contractile action to acetylcholine of small doses, did not affect that to acetylcholine of high dose, markedly inhibited the contratile action to pilocarpine, histamine and serotonin. In circular muscle of colon, verapamil augmented the spontameous movement to acetylcholine, wherease the contractile actions to acetylcholine was suppressed by only high dose of verapamil, verapamil did not influence the contractile action to pilocarpine and serotonin, enhanced the spontaneous movement caused by pilocarpine of high dose, and by serotonin but inhibited both action to histamine and spontaneous movement to pilocarpine of small dose.
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烏梅(Mume Fructus)水性엑스의 家兎 腸運動에 미치는 影響
高錫太,朴炫貞,任光楠 조선대학교 약학연구소 1994 藥學硏究誌 Vol.16 No.1
Effect of .Mume Fructus on intestinal function was investigated in rabbit, making use of its water extract. Mume Fructus water extract(MWE), of small doses(0.1, 0.3㎎/ml) produced contractile action but did not effect the spontaneous movement strips of high dose(1.0㎎/ml) elicited relaxative action and the inhibition of spontaneous movement in ileum strips. In lieum strips, MWE did not influence the contractile action but augmented the spontaneous movement to acetylcholine, MWE elicited the inhibition of contractile action and the agumentation of spontaneous movement to pilocarpine, MWE inhibited the both actions to histamine, did not affect to serotonin and blocked to dopamine. MWE exhibited the relaxation and the inhibition of spontaneous movement in longitadinal muscle of colon. In longitudinal muscle of colon, MWE inhibited both actions to acetylcholine, did not influence the contractile actions but augmented the spontaneous movement to histamine and serotonin. MWE elicited the increase of contractile actions and the decrease of spontaneous movement in circular muscle of colon. In circular muscle of colon, MWE augmented both actions to acetylcholine, inhibited both actions to serotonin, and then did not affect the contractile action but augmented the spontaneous movement to histamine.
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