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이형기,김종성,박영수,강정구,박진수,Lee, Hyong-Ki,Kim, Jong-Seng,Park, Young-Su,Gang, Jeong-Gu,Park, Jin-Su 해양환경안전학회 2011 해양환경안전학회지 Vol.17 No.2
지난 60년간 급속한 항만 개발로 인하여 다량의 해도가 여러 종류의 축척 및 구역으로 제작되어 인접구역이 효과적으로 연결되지 못하거나 과도한 중첩 구역이 발생하는 경우가 있으며 무리한 제분도의 사용으로 이용자에게 혼란 및 불편을 야기하고 있는 실정이다. 이 연구의 목적은 대한민국에서 간행되는 해도의 구역 및 축척별 분석을 통하여 새로운 해도구역 조정안을 제시하는데 있으며 이를 통해 항해 편의를 제공하는데 있다. 합리적인 해도구역 조정을 위하여 연구진이 전문가 의견법을 통하여 개정안을 마련한 후 이용자를 대상으로 한 설문조사 및 도선구역별 도선사 협회의 의견 수렴 등을 통하여 그 타당성을 검증받고 의견을 수렴하여 보완하였다. 연구의 결과로 현재 간행되고 있는 309장의 해도는 334장으로 변경되었다. Navigational charts in Korea have been increasingly published in line with the development of harbour for 60 years without a detailed planning. Recently, charts cause inconvenience to use and make navigator confused because they have not been adjoined to adjacent chart effectively and have been to overlap with other charts of the same scale. In this paper, we propose new chart system through adjusting area of the chart and rearranging its scale. This newly proposed scheme was first designed by researchers who have on-board career, then has been verified and revised by questionnaire and pilots' opinion. As a result, total number of Korean chart could be changed from 309 to 334.
이형기,Lee, Howard 대한임상약리학회 2012 臨床藥理學會誌 Vol.20 No.1
The equivalence margin is the largest difference that is clinically acceptable between the test (or experimental) drug and the active control (or reference) drug. This paper discusses the scientific principles, along with the regulatory issues, that need to be addressed when determining the equivalence margin for the biosimilar product. The concept of assay sensitivity is introduced, and the ways to ensure assay sensitivity in the equivalence trial are emphasized. A hypothetical example is presented to show how an equivalence margin is determined. The regulatory agency should carefully assess if the equivalence margin of the biosimilar product was determined using a scientifically valid and clinically relevant approach, not subject to selection bias. This is important because the consumer risk of erroneously declaring equivalence when in fact it is not must be controlled conservatively low in the approval of any biosimilar products.
이형기,옥영길,최용훈,정호,Lee, Hyung-Kee,Ok, Young-Kil,Choi, Yong-Hun,Kim, Jung-Ho 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.2
Objective : To investigate how general characteristics and life habits of patients affect severity of acne which was determined by Korean Acne Grading system(KAGS). To adress correlation between the severity of acne and subjective stresses from which patients suffer. Methods : 86 patients answered to questionaire sheet on their general characteristics and life habits and rated their level of stresses as a number in the range between 0 and 10. Then an oriental medical doctor evaluated subject's acne grades, based of KAGS, through observations on papules, nodules, and scars before (medical) treatments. All data (collected) were analyzed using SPSS 22 (software for windows). To clearly demonstrate association of subjects general characteristics, life habits with KAGS grades, Chi-square tests were performed. The correlation between the KAGS grades and the level of stresses was determined using one-way ANOVA followed by Scheffe's post-hoc analysis. Results & Conclusion : Majority of subjects were women, students between 15 and 25 years old, and patients with normal range of Body Mass Index(BMI). Dysmenorrhea presence and premenstrual exacerbation of acne had statistically significant relationship, suggesting their potential influences on KAGS grades as major factors.
이형기,조수영,김규남,최용훈,이정환,김정호,Lee, Hyung-Kee,Cho, Soo-Young,Kim, Kyu-Nam,Choi, Yong-Hun,Lee, Jung-Hwan,Kim, Jung-Ho 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.1
Objective : This study performed to evaluate that duration of acne scars effects on Qualitative Global Acne Scarring Grading System(QGASC) grade changing and treatment duration. Also this study performed to evaluate the relationship between dysmenorrhea and acne scars, and the effects of each treatment on treatment duration and Korean Acne Grading System(KAGS) and QGASC grade.Methods : 95 patients with acne scars were understood by medical records and case photos, and we evaluated pre and post acne scar grade based on KAGS and QGASC. We analyzed data by SPSS 22 for windows program, and figured out the relation between duration of acne and QGASC grade and treatment duration by Spearman correlation analysis, and performed Mann-Whitney U-test to figure out the relation between dysmenorrhea and QGASC grade. We performed Wilcoxon test to evaluate that treatment of acne scars effects on KAGS grade and QGASC grade, and performed Kruskal-Wallis test to figure out the difference of each treatment which effects on KAGS grade and QGASC grade, and performed Post-hoc analysis to figure out the group comparison.Results & Conclusions : QGASC grade depending on duration of acne was statistically significance. Subcision and Microneedle Therapy System(MTS) and pharmacopuncture were significantly improved acne scars. Other treatments were significantly more effective than subcision and pharmacopuncture combined treatment. Treatment duration of Subcision and MTS combined treatment was significantly most shortest than other treatment.
이형기,김송현,김현수,김기량,김관형,Lee, Hyung-ki,Kim, Song-Hyun,Kim, Hyun-soo,Kim, Gi-ryang,Kim, Gwan-Hyung 한국정보통신학회 2015 한국정보통신학회논문지 Vol.19 No.11
발전기의 전압조정장치(AVR)를 이용하여 전압을 조절하는 방식은 기존 아날로그방식과 교체중인 디지털방식을 나눌 수 있다. 일반적으로 브러쉬레스형의 여자시스템을 이용하여 전압을 조절할 경우 전부하에 대하여 전압변동을 작게 하여야 한다. AVR의 제어방법으로 PID(비례-적분-미분)제어방식이 많이 사용되고 있다. 그러나 이 제어기법은 제어대상에 대하여 제어기의 파라미터를 조절하여 과도응답을 줄이고 있다. 따라서 제어대상이 달라질 경우 다시 제어기의 파라미터를 다시 설정해야하는 문제점이 있다. 본 연구에서는 제어대상의 파라미터 변동에 대하여 제어기의 파라미터를 재설정 필요없이 iPID(intelligent PID)제어기를 이용하여 발전기 AVR시스템에 적용하여 전부하 시에도 전압변동이 작은 응답을 얻도록 설계하고 시뮬레이션과 실험을 통하여 과도응답을 개선하였다. Method for regulating voltage using a generator voltage regulating device (AVR) is divided in an existing analog system and a digital replacement. Typically, to adjust the voltage by using a brushless excitation system of the type to be reduced for a voltage change under all. The control method of the AVR as a PID (proportional-integral-differential) control method is widely used. However, the control scheme is to reduce the transient response of the control parameters of the controller to the control object. Therefore, if the control target should change, there is a problem, reset the parameters of the controller again. In this study, without having to reset the parameters of the controller for the parameter variations to be controlled iPID (intelligent PID) using a controller designed to obtain a generator AVR system voltage variation is small in response to full load is applied to and through simulations and experiments improved transient response.