Review of Advances in Biological CO2 Mitigation Technology

이진석,Joon-Pyo Lee 한국생물공학회 2003 Biotechnology and Bioprocess Engineering Vol.8 No.6

CO2 fixation by microalgae has emerged as a promising option for CO2 mitigation. Intensive research work has been carried out to develop a feasible system for removing CO2 from industrial exhaust gases. However, there are still several challenging points to overcome in order to make the process more practical. In this paper, recent research activities on three key technologies of biological CO2 fixation, an identification of a suitable algal strain, development of high efficient photobioreactor and utilization of algal cells produced, are described. Finally the barriers, progress, and prospects of commercially developing a biological CO2 fixation process are summarized.

평가원리포트2 - 계란 판매현황 조사 결과

이진석,Lee, Jin-Seok 축산물품질평가원 2012 KAPE누리 Vol.195 No.-

특별기고 - 닭고기 등급판정은 왜 필요한가!

이진석,Lee, Jin-Seok 한국육계협회 2012 월간 닭고기 Vol.18 No.7

당과 후기당화합물에 의한 사구체 상피세포 ZO-1 발현의 변화

이진석,이해수,윤옥자,하태선,Lee Jin-Seok,Lee Hae- Soo,Yoon Ok-Ja,Ha Tae-Sun 대한소아신장학회 2004 Childhood kidney diseases Vol.8 No.2

목적: 단백뇨 질환에서 볼 수 있는 사구체 상피세포(glomerular epithelial cells, GEpC) 족돌기(foot process)의 병리학적 변화에 있어서 GEpC사이의 세극막(slit diaphragm)과 세포골격을 연결하는 ZO-1 단백의 당뇨조건에 따른 변화를 알아보고자 하였다. 방법: 백서 GEpC을 배양하고 고농도의 당과 후기당화합물(advanced glycosylation enduroducts, AGE)를 적용하여 당뇨병 환경에 가까운 조건을 설정한 후, ZO-1 단백양은 Western 분석으로, 분포 변화는 공초점 현미경으로, 유전자 표현의 변화는 RT-PCR로 관찰하였다. 실험군은 당의 농도를 5 또는 30 mM로, AGE와 BSA를 첨가하고 osmotic control로서 당 5 mM에 mannitol 25 M을 섞은 것을 조합하여 A5, A30, B5, B30, Aosm로 하였다. 결과: 공초점 현미경 상 ZO-1은 정상적인 환경인 B5에서 B30, A5, 가장 병적인 A30 환경으로 진행할수록 세포질의 바깥에서 안쪽으로 이동하는 양상을 보였다. ZO-1 단백양은 B5 결과를 대조군으로 비교하여 당을 첨가한 B30에서 11.1%, AGE를 추가한 조건인 A5에서 2.3% 감소하였나 통계적 유의성은 없었고, 당과 AGE가 동시에 첨가된 A30에서는 19.0%의 유의한 감소를 보였다. mRNA의 발현도 A30에서만 12.0%의 의의 있는 감소를 보였다. 이러한 단백질과 mRNA의 감소 소견은 osmotic control (Aosm)에서는 관찰할 수 없었다. 결론: 고농도의 당과 AGE에 의한 GEpC의 ZO-1의 분포 변화와 유전자 수준에서의 억제로 단백의 생성 감소를 초래함으로써, 장기간 당뇨 환경체서 족돌기의 형태학적 변화를 설명할 수 있으며, 추후 이의 변화 기전에 대한 연구가 필요할 것으로 사료된다. Purpose: Regardless of the underlying diseases, the proteinuric condition demonstrates ultrastructural changes in podocytes with retraction and effacement of the highly specialized interdigitating foot processes. We examined the molecular basis for this alteration of the podocyte phenotypes, including quantitative and distributional changes of ZO-1 protein as a candidate contributing to the pathogenic changes in the barrier to protein filtration. Methods: To investigate whether high glucose and advanced glycosylation endproduct(AGE) induce podocyte cytoskeletal changes, we cultured rat GEpC under 1) normal glucose(5 mM=control) or 2) high glucose(30 mM) or 3) AGE-added or 4) high glucose plus AGE-added conditions. The distribution of ZO-1 was observed by confocal microscope and the change of ZO-1 expression was measured by Western blotting and RT-PCR. Results: By confocal microscopy, we observed that ZO-1 moves from peripheral cytoplasm to inner actin filaments complexes in both AGE-added and high glucose condition. In Western blotting, high glucose or AGE-added condition decreased the ZO-1 protein expression by 11.1%(P>0.05) and 2.3%(P>0.05), respectively compared to the normal glucose condition. High glucose plus AGE-added condition further decreased ZO-1 protein expression to statistically significant level(12%, P<0.05). No significant change was seen in the osmotic control. In RT-PCR, high glucose plus AGE-added condition significantly decreased the expression of ZO-1 mRNA by 12% compared to normal glucose condition. Conclusion: We suggest that both high glucose and AGE-added condition induce the cytoplasmic translocation and suppresses the production of ZO-1 at transcriptional level and these changes may explain the functional changes of podocytes in diabetic conditions.

시뮬레이션을 이용한 전시국내 육로 수송 능력평가

이진석,이상진,Lee, Jin-Seok,Lee, Sang-Jin 한국국방경영분석학회 2005 한국국방경영분석학회지 Vol.31 No.1

The ROK TRANSCOM and Army Logistics Command have established wartime overland transportation plans. They have to mobilize several wartime overland transportation troops in order to meet the wartime transportation requirement. But there are some uncertainties in the process of transportation such as the number of vehicles to mobilize, the vehicle utilization factor, and round trip time. Here, we established two models. One is the simulation model to evaluate the transportation capability considering uncertain factors. The simulation model is executed with two scenarios and then the results are analyzed through a sensitivity analysis. The other model is the regression model to analyze the effects of transportation factors toward capability.

심낭삼출로 발병하여 스테로이드 단독치료로 호전된 소아 전신성 홍반성 낭창 1례

이진석,하태선,Lee Jin-Seok,Ha Tae-Sun 대한소아신장학회 2004 Childhood kidney diseases Vol.8 No.1

저자들은 급성 호흡곤란을 주소로 내원하여 반복적 심낭삼출로 2차례 심막천자술을 시행하였으나 심증상이 지속되다가 이후 발생한 임상적 소견과 혈액검사로 전신성 홍반성 낭창을 진단하여 부신피질호르몬을 투여한 후 심증상의 뚜렷한 호전을 보인 11세 여환아를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The systemic lupus erythematosus(SLE) is a systemic inflammatory disease caused by autoimmune mechanism, involving blood cells, the kidney, the central nervous system, and etc. The heart is one of the frequently involved organs but it is rare as an initial manifestation. Therefore, early suspicion and accurate diagnosis followed by aggressive immunosuppressive therapy including corticosteroid is mandatory for heart-involved patients. We experienced a case of pericardial effusion as an initial manifestation of childhood SLE, which showed immediate response to corticosteroid.

옥수수, 콩 등 작물로 자동차 연료 만든다

이진석,Lee, Jin-Seok 한국과학기술단체총연합회 2005 과학과 기술 Vol.38 No.10

수지에 발생한 정맥류 - 2예 보고 -

이진석,정영진,손형빈,홍인표,Lee, Jin-Seok,Jung, Young-Jin,Sohn, Hyung-Bin,Hong, In-Pyo 대한미세수술학회 2008 Archives of reconstructive microsurgery Vol.17 No.1

Varix of the digit is generally defined as an enlarged, tortuous palmar digital vein with or without thrombus within it. It usually presents as a firm, blue mass on the volar aspect of the finger. Mechanical compression or chronic trauma to veins on the volar surface of a digit appears central to the pathogenesis of this lesion. Aging phlebectasia has also been considered as a cause of this lesion in the elderly. A tourniquet test may be useful in demonstrating the presence of a digital varix, but it is confirmed by postoperative microscopic examination. Excision of a symptomatic lesion has proven to be curative. We report two cases of symptomatic digital varix which developed in the fourth finger with a review of literatures.

성인남성 흡연자의 흡연행태 변화와 관련 요인

이진석,김양중,김원년,황승식,김용익,Lee, Jin-Seok,Kim, Yang-Jung,Kim, Won-Nyon,Hwang, Seung-Sik,Kim, Yong-Ik 대한예방의학회 2006 예방의학회지 Vol.39 No.4

Objectives: This study (a) investigated the rate of smoking cessation sucess for current male smokers, and (b) identified the factors that are associated with the smoking cessation success. Methods: Data were collected from four follow-up surveys of 700 current male smokers. The follow-up period was from December 2004 to June 2005. Success of smoking cessation was defined as "maintaining a smoking cessation status for six months". The demographic and socioeconomic factors included age, the household income level and, occupation. The smoking behavioral factors were composed of the amount of smoking, the duration of smoking, the age of initiating smoking, the willingness to quit, the frequency of trying to quit smoking and the smoker's attitude toward the anti-smoking policies. Results: The proportion of quitters increased from 6.6% to 11.0% during the follow-up period. The majority of quitters answered that the increase of tobacco price acted as cue to achieve smoking cessation. The age-standardized experience and success rate of smoking cessation were 16.0% (95% C.I.=13.0% to, 19.0%) and 4.5% (95% C.I.=3.0% to, 6.0%), respectively. On the multivariate analysis, success for smoking cessation was associated with the willingness to quit smoking, low prior tobacco consumption, and agreement on the tobacco price increase. Conclusions: The results of this study suggest that the recent anti-smoking policies provided an opportunity to quit smoking. The results of this study can be used to establish evidence for further anti-smoking policies.

전문가심층분석 - 액란에도 3월 21일부터 등급표시가 있다!

이진석,Lee, Jin-Seok 축산물품질평가원 2011 KAPE누리 Vol.175 No.-

축산물품질평가원에서는 2001년부터 계란등급판정을 실시하고 있으며 학교급식과 대형유통회사(풀무원, 오뚜기, CJ 등)를 필두로 등급판정 받은 계란을 판매 및 사용하였다. 계란 등급판정은 주로 계란집하장에서 이루어지고 있으며 계란 등급판정시행업체는 2009년 27개소, 2010년 30개소로 점차 확대 되어왔다.