신규 캄토테신계 항암제 CKD-602의 약물동태 : 분포, 대사 및 배설

이주몽(Ju Mong Lee),이준희(Jun Hee Lee),김준겸(Joon Kyum Kim),신희종(Hee Jong Shin),이형기(Hyung Ki Lee),이상준(Sang Joon Lee),홍청일(Chung Il Hong) 大韓藥學會 1998 약학회지 Vol.42 No.4

The distribution, metabolism and excretion of CKD-602{20(S)-7-[2-(N-Isopropylamino)ethyl]camptothecin HCI), a new camptothecin derivative, were investigated in rats after a single administration of CKD-602. 1. The tissue levels of CKD-602 given to mice by the intravenous route at a dose of 20mg/kg were the highest in intestine, followed in descending order by kidney, liver, stomach,lung, heart, spleen and plasma. The concentrations of CKD-602 after 24hrs decreased to less than 2% of the peak level in most tissues except the skin. The urinary and fecal excretion of CKD-602 were 47.6% and 44.4% of the administered dose, respectively, with 0.7% remaining in the rinse. 2. After administration of CKD-602 at 10mg/kg in rats, metabolism of this compound was examined in plasma, urine, and feces. The plasma samples were collected for 24hr, urinary and fecal samples for 72hr. While any peak of CKD-602 in HPLC chromatograms was not detected from plasma and urine it was detected in feces (peaks, 9.8 min). However, additional peak area was about 0.5% of the peak area of parent CKD-602. Therefore, CKD-602 may be eliminated with the parent form and rarely metabolized in the body. 4. After I.v. administration of CKD-602 at 10mg/kg in rats, urinary and fecal excretions were examined for 72hrs post dose period. 87% of total urinary excretion of CKD-602 was excreted within 8hr after administration, 53%, and 32% of total fecal excreted amounts were determined in 0-24 hr and 24-48hr periods, respectively. The total excretion amounts of CKD-602 into urine and feces were 94% of the administered dose.

평균전파길이를 이용한 호남권 풍력산업 네트워크 분석

이학래(Lee, Hag-Rae),나주몽(Na, Ju-Mong) 한국지역개발학회 2013 한국지역개발학회 세미나 논문집 Vol.2013 No.1

In this study, using the 2005 regional input-output tables, analyze the average propagation length of Honam area, measuring the differentiation degree of inter-industry, the production chain of the wind power industry through a social network analysis this I analyzed the structure. The analysis of the average propagation length, industrial petroleum products, finance, insurance, and land transportation of Honam speaking strong function of intermediate goods supply to other industries, average propagation length of the front is high, steel primary products, such as synthetic rubber or synthetic resin, average length of the rear transmission is high in industry tend to be used as an intermediate material the results of other industries increases. It shows a high degree of concentration and 60.355% highest industrial equipment and electrical equipment of the wind power, it is possible to see association with other industries the wind power industry is the highest. The results from this, first, the relationship between the manufacturer and shipbuilding industries located in Honam area, so stronger than other industries, in order to enhance the ripple effect throughout the industry, the relationship with the previousㆍbackward linkage industry it is necessary to improve. It should be the second, not performed well at the area level equipment engineering and specialty construction and civil, research, and performance evaluation, is to have the active cooperation system of related industries in this area. The wind power industry in Honam area, that the third, looking at network spring wind power industry (Spring) map, that it is not located in the center of the industry between the specific gravity compared to other industries other ever This indicates that the weak.

사회네트워크분석을 이용한 풍력산업 네트워크 구조 분석

이학래(Lee, Hag-Rae),나주몽(Na, Ju-Mong) 한국지역개발학회 2013 韓國地域開發學會誌 Vol.25 No.5

This study aimed to analyse the average path length of the wind power industry network in the Honam Economic Region using the 2005 Input-Output Tables presented by Bank of Korea(2009). For this purpose, the study analysed the degree of industry specialization and the social networks needed to understand the structure of the production chains in industry specialization. As a result of analysing the average path length, it was discovered that primary industries such as iron and steel, chemical products, and motors tended to use products of other industries as intermediate materials in Honam. As a result of analysing the networks of the wind power industry in Honam, networks became connected at a higher rate than they were separated. This means that industries related to the wind power industry were well-connected with other industries. Political suggestions for the development of the wind power industry in Honam are the following. First, metal products and mechanical components for general use in the wind power industry had a high connection rate with specific industries and the structure of the networks was dispersed. Second, within Honam there exists 80% of the components used in the wind power and generator industries, and 20% of the installation and development services. In particular, the local installation and development services were weak. The third, the weight of the wind power industry in Honam was weaker than that of other industries when compared to companies dealing in plastic, metal products, components for general use, electric appliances and other devices which were not in a central location as seen in a network spring map.

2012여수세계박람회가 여수지역에 미친 경제적 파급효과 분석

이정록 ( Jeong Rock Lee ),이철 ( Cheol Lee ),나주몽 ( Ju Mong Na ) 한국경제지리학회 2015 한국경제지리학회지 Vol.18 No.2

2012여수세계박람회는 2012년 5월부터 8월까지 전남 여수시에서 개최된 대표적인 특별 이벤트에 해당한다. 특별 이벤트가 개최된 후에는 이벤트 개최의 경제적 파급효과를 분석한 연구들이 다수 발표되는 것이 일반적이다. 하지만, 여수세계박람회가 개최된 후에도 관련연구가 지금까지 부재하였다. 이런 문제점에 의거하여 이 연구의 목적은 여수세계박람회 개최가 여수지역에 미친 경제적 파급효과를 실증적으로 분석하는 것이다. 여수세계박람회 개최는 여수지역에 실질적인 경제적 파급효과를 제공한 것으로 밝혀졌다. 특히 사업체수 증가, 사업체의 종합소득세 증가가 구체적으로 나타났고, 관광관련 업종인 음식점과 숙박업에서 뚜렷한 증가세를 보였다. 입지상법에 의한 경제적 파급효과 분석결과를 보면, 여수지역 내에 생산유발 85,783억 원, 부가가치 유발효과 29,996억 원, 소득유발 15,863억 원, 고용유발 5만 3,512명이 발생하였다. 여수지역 내에서 발생한 관광부문의 경제적 파급효과는 생산유발 38,097억 원, 소득유발 6,507억 원, 부가가치유발 13,701억 원, 고용유발 25,313명 등으로 분석되었다. The EXPO 2012 Yeosu Korea is a leading special event held in Yeosu city, Jeonnam Province from May to August 2012. It is a general expectation to encounter many research papers on the analyses of economic impacts of special event after the event was held. As far as we found, however, there is no related research. With based on these issues, the aim of this article is to identify and examine the economic impacts of the EXPO 2012 Yeosu Korea in hosting area, Yeosu area. The economic impacts of EXPO 2012 Yeosu Korea in Yeosu area are as follows; increase of total number of business, increase of total amount of global income tax, in particular, tourism related business such as food and hospitality sectors, production inducement effect about 8 trillion and 5,783 billion won in the entire industrial sector, and production inducement effect about 3 trillion and 8,097 billion won in the tourism related industrial sector.

연구논문 : 정부투자에 의한 고용창출의 경제적 파급효과에 관한 연구 -산업연관분석을 중심으로-

이학래 ( Hak Rae Lee ),나주몽 ( Ju Mong Na ) 전남대학교 지역개발연구소 2009 지역개발연구 Vol.41 No.1

중국의 지역별 총요소생산성 변화에 관한 연구

장첸(Zhang Chen),이창호(Lee Chang-ho),나주몽(Na Ju-Mong) 한국지역개발학회 2016 한국지역개발학회 세미나 논문집 Vol.2016 No.1

Total factor productivity (TFP) is deemed as one of the important factors on national and regional economic growth. TFP is the efficiency of the producing activities within a certain time. In output increase rate, the part which is more than input factors increase rate is termed TFP. The western development policy is put forward by Chinese government in 2000s. It is a long-term plan of regional development until 2050s. It aims to complete the infrastructure construction in a short time, and to set up a close relationship between macro-region and middle and small areas then build a regional network within a long time. This study evaluated the total factor productivity of 30 regions in China. Especially how TFP chang in 11 western Regions. First we chose the regional inputs and outputs elements, then used MPI to get the results. According to the analysis results, we evaluated the situation about the implementation of the western development policy from 2004s to 2013s.

창조도시정책의 추진과정과 성과에 대한 국제적 비교연구: 영국, 프랑스, 호주, 일본, 한국을 사례로

신동호 ( Shin Dong-ho ),이정록 ( Lee Jeong Rock ),이병민 ( Lee Byung-min ),배준구 ( Bae Jun-gu ),나주몽 ( Na Ju-mong ) 한국경제지리학회 2016 한국경제지리학회지 Vol.19 No.4

1970년대 이후 산업화시대가 퇴조함에 따라 선진공업국의 경제가 크게 변하였다. 국가경제의 중심적 역할을 하던 대규모 공업도시의 경제가 몰락하여 대량실업과 도시경관의 파괴 등이 심각한 사회문제로 부각되었다. 이러한 상황에 대비하여 리차드 플로리다, 찰스 랜드리 등은 창조성에 기초한 경제구조의 전환을 주장하였고, 영국, 미국, 프랑스 등 세계 여러 나라들은 그러한 주장을 수용하여 창조도시쟁책을 추진하였다. 필자들은 영국, 프랑스, 호주, 일본, 한국 등이 조성하고자 한 대표적 창조도시에 관한 정책 추진과정과 체계, 성과 등을 국가별로 분석하고 정책적, 이론적 시사점을 도출하였다. 본 연구는 각기 추진한 그러한 국가별 사례연구를 종합하여 비교·분석하고, 정리한 것이다. Since the 1970s, advanced industrial economies have been suffering from rapid de-industri-alization. While the impacts were more serious in the areas specialized in heavy industries, these old industrial areas are struggling with problems of high unemployment, environmental contamination and destruction of urban landscape. To tackle such problems and rebuild urban economies, some authors, such as Richard Florida and Charles Lanrdry, have suggested a new economy centered on “creativity.” Adopting this suggestion, many countries have been attempting to create creative cities. Authors of this paper individually conducted a case study research on a few selected cities of England, France, Australia, Japan and Korea. This paper synthesizes the results of such research to compare and analyse the processes and mechanisms contributed to developing the creative cities in each country and draw theoretical and policy implications from the individual research.

신규 Carbapenem 유도체 CRB 529 및 CRB 550의 생체내 항균효과와 약물동태의 비교

김준겸(Joon Kyum Kim),민관기(Kwan Kee Min),이주몽(Ju Mong Lee),이홍우(Hong Woo Lee),김정우(Jung Woo Kim) 대한약학회 1995 약학회지 Vol.39 No.4

1-beta-Methyl carbapenem-2-substituted pyrrolidine derivatives, CRB 529 and CRB 550, were synthesized as investigational carbapenem derivatives. It has been reported that the in vitro antibacterial activities of the compounds against G(+) and G(-) bacteria were almost the same or more effective than those of imipenem (IPM) and meropenem (MEPM), and also showed better in vivo efficacy than MEPM and imipenem/cilastatin (IPM/CS) against representative G(-) organisms, P. aeruginosa and MRSA organisms, S. aureus. The antibacterial activities, pharmacokinetics and protective efficacy of IPM/CS and CRB 529 and CRB 550 were conducted after subcutaneous or intravenous administration to mice and rats. The pharmacokinetic parameters of CRB 529 and CRB 550 in mice were as follows; the observed maximal serum concentrations (CMAX) following I.V. administration were 87.5 and 101mcg/ml for CRB 529 and CRB 550, respectively, and 63.6mcg/ml for IPM/CS. The half-lives (t1/2) were 14.0 and 12.0 min for CRB 529 and CRB 550, respectively, and 14.8 min for IPM/CS. In rats, CMAX after I.V. administration were 74.0 and 91.8mcg/ml for CRB 529 and CRB 550, respectively, and 41.2mcg/ml for IPM/CS. The tissue levels of CRB 529 and CRB 550 and IPM/CS after I.V. administration at a dose of 20mg/kg decreased by the following order; lung, heart, kidney, liver and spleen for CRB 529, kidney, liver, lung, heart and spleen for CRB 550 and kidney, lung, liver, heart, spleen and brain for IPM/CS. In systemic infection, CRB 529 and CRB 550 showed excellent efficacies against P. aeruginosa and S. aureus (MRSA) at a dose of 5mg/kg. The PD50s were 0.80, 0.36mg/kg for CRB 529 and CRB 550, respectively, and 3.22mg/kg for IPM/CS against P. aeruginosa. The corresponding values against S. aureus (MRSA) were 76.0, 55.3mg/kg for CRB 529 and CRB 550, respectively, and 146mg/kg for IPM/CS. In local infection, the antibacterial activities of CRB 529 and CRB 550 were more effective than those of IPM/CS against intrarenal infection with E. coli and P. aeruginosa and also showed as effective as IPM/CS against respiratory tract infection with E. coli and P. aeruginosa at a dose of 5mg/kg.

Allopurinol이 Rat에서의 Arachidonic Acid 유발 혈소판 응집과 Mice에서의 혈전성 폐색전에 미치는 효과

이주몽,허인회 중앙대학교 약학연구소 1995 약학 논총 Vol.9 No.-

This study was performed to free radical scavenging of xanthine-oxidase inhibitor, allopurinol. In pulmonary thromboembolism in mice, intraperitoneal administration of allopurinol decreased dose-dependently mortality or paralysis by intravenous infusion of collagen plus epinephrine. But, Ca^2+ antagonists (p.o.) did not cause significant decrease in thromboembolism. Among Ca^2+ antagonists, nifedipine with allopurinol decreased significantly thrombotic challenge. In arachidonic acid (AA)-induced platelet aggreagtion, allopurinol only caused inhibition platelet aggregation at 10^-3 M. Pyrogallol increased AA-induced platelet aggregation by superoxide anion production. Allopurinol at any concentration decreased significantly the increment of AA-induced platelet aggregation by pyrogallol. In conclusion, allopurinol had the mechanism of free radical scavenging other than xanthine oxidase inhibition and had the activity to be show protection on the pulmonary thromboembolism with vasodilator.