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- 저자 : 이종원(long-Won Lee) (검색결과 2 건)
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본태성 고혈압환자의 혈장 Catecholamine 농도에 관한 연구
이종원(Long Won Lee),장주희(Joo Hee Jang),김병호(Byung Ho Kim),김권삼(Kwon Sam Kim),김명식(Myung Shick Kim),배종화(Jong Hoa Bae),송정상(Jung Sang Song) 대한내과학회 1986 대한내과학회지 Vol.30 No.6
N/A In order to evaluate the significance of sympathetic nerve activity in the pathophysiology and pathogenesis of essential hypertension, plasma norepinephrine concentration(PNE), plasma epinephrine concentration(PE) and plasma renin activity(PRA) at supine rest and after 30 minutes ambulation were evaluated in 107 patients with sustained essential hypertension(EHT), 39 patients with borderline hypertension(BHT) and 51 normal controls(NT) The results were as follows; 1) Age dependent increase of PNE was observed in NT group, but not in EHT and BHT groups. 2) In supine resting state; PNE levels of patients with EHT and BHT were significantly higher than that of NT in young and middle age groups. 3) In supine resting state, PNE levels of patients with BHT were higher than that of patients with EHT, but only significant in old age group. 4) Postambulatory PNE levels were higher in patients with EHT and BHT than that of NT in all age groups. 5) Postambulatory PNE levels of patients with BHT were significantly higher than that of patients with EHT in middle and old age groups. 6) PE levels of both the NT and hypertensive group were not related to age and there was no difference in PE levels between NT and hypertensive group. 7) There was no correlation between PRA and PNE level in both NT and EHT groups but postambulatory PNE levels were significantly higher in patients with NRH than that of patients with LRH. From the results observed in this study, it is suggested that increased sympathetic neural activity might play an importantt role in the pathogenesis and maintenance of a high blood pressure of essential hypertension, especially in young, mild or renin unsuppressed patients.
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이종원(long-Won Lee),김나미(Na-Mi Kim),도재호(Jae-Ho Do) 고려인삼학회 2004 Journal of Ginseng Research Vol.28 No.3
This study was carried out to investigate the effect of red ginseng water extract (RGWE) on trypsin activity. After extraction of fat soluble and saponin component from red ginseng powder by methyl alcohol. the residue was extracted with distilled water. and manufactured to water extract. The extract was dialyzed with different molecular cut ott membrane. Trypsin activity demonstrated the highest level at the RGWE concentration of 9x I 0-2 % in reaction mixture. and also increased to 15% at 2.9x I 0-:1 %. Km value was decreased and Vmax was increased in the present of red ginseng water extract. Red ginseng water extract was partially purified by dialysis. Bio-Gel P-IO and DEAE-cellulose column chromatography. The active fraction demonstrated positive reaction to ninhydrin, DNS and folin reaction.<br/>
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