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흰쥐 분리 간세포에 있어서 딜티아젬의 간클리어런스에 미치는 페노바르비탈의 영향
이용복,오준교,고익배,Lee, Yong-Bok,Oh, Joon-Kyo,Kho, Ik-Bae 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.1
In order to study the effect of phenobarbital(PB) on the hepatic transport of diltiazem(DTZ), $Ca^{2+}$ channel blocker, we used isolated hepatocytes of rat which was intraperitoneally pretreated with phenobarbital sodium(75 mg/kg) for four days once a day. For the isolation of rat liver cells, a modification of the two step procedure of Seglen was used. DTZ was dissolved in incubation buffer to the final DTZ concentrations of 200, 400, 600, 800 and 1000 ng/ml in order to elucidate the uptake characteristics of DTZ by hepatocytes. Reactions were stopped at 10, 20, 30, 45, 60, 90, 120 and 300 sec. The initial velocity was determined by disappearance of diltiazem in the hepatocyte suspension. On the other hand, to determine the effect of PB on the in vitro hepatic intrinsic clearance of DTZ we obtained the metabolism rates of DTZ in the control and the PB-pretreated rat hepatocyte at various time intervals. According to pretreatment with PB, the size of hepatocyte and the amount of protein per $10^6$ cells were significantly (p<0.01) increased from $26.92{\pm}0.1364\;m$ to $35.31{\pm}1.00\;m$ and from $468{\pm}6.5\;{\mu}g/10^6$ cells to $628.8{\pm}12.1{\mu}g/10^6$ cells, respectively. In the case or hepatic uptake of diltiazem, $K_m$ was not different in the normalization by cell numbers and increased from $2.90\;{\mu}M\;to\;13.89\;{\mu}M$ in the normalization by protein amount. $V_max$ was increased regardless of normalization by protein amount and cell numbers, from $1.21\;{\mu}mole/min \;{\cdot}\;mg\;protein\;to\;3.96\;{\mu}mole/min\;{\cdot}\;mg\;protein\;and\;from\;2.38\;{\mu}mole/min\;{\cdot}\;10^6\;cells\;to\;2.83\;{\mu}mole/min\;{\cdot}\;10^6\;cells$, respectively. The in vitro hepatic intrinsic clearance of DTZ was significantly (p<0.01) increased from $0.640{\pm}0.038\;ml/mim\;{\cdot}\;10^6\;cells\;to\;2.385{\pm}0.212\;ml/min\;{\cdot}\;10^6\;cells$ due to PB-pretreatment. These results suggest that the uptake of DTZ by hepatocyte is extremely fast and PB enhances the hepatic intrinsic metabolic clearance of DTZ.
SS330 용접재에서 재분포 잔류응력 및 균열닫힘영향을 고려한 파로거동에 관한 연구
이용복,정진성,조남익,Lee, Yong-Bok,Jeong, Jin-Seong,Jo, Nam-Ik 대한기계학회 1996 大韓機械學會論文集A Vol.20 No.7
In this study residual stress in weldment was considered about the effect on the fatigue propagation and about the effect of redistribution of residual stress. Then, fatigue tests were conducted by the center notched specimens machined with welded plate. The residual stress and its redistribution after the crack growth were measured by the magnetizing stress indicator and hole-drilling method. Fatigue crack propagation was estimated by the specimens having residual stress redistributed after the cracks growth and having the effects of crack closure. Crack growth rates were predicted and compared with experimental results. It had been found that the predicted crack propagation rates have a good agreement with experimental results when the redistribution of residual stress was considerd.
시메티딘이 간혈류량에 미치는 영향 - Rat에 있어서 Indocyanine Green의 체내 동태를 중심으로 -
이용복,고익배,Lee, Yong-Bok,Koh, Ik-Bae 한국임상약학회 1993 한국임상약학회지 Vol.3 No.2
The influence of cimetidine pretreatment(100mg/kg, single i.p.) on the hepatic blood flow was investigated using pharmacokinetic parameters of indocyanine green(ICG) in the rat on the basis of hepacc perfusion-limited model. ICG(1mg/kg) was respectively administered via femoral and portal vein to the control and to the cimetidine-pretreated rats. The rate constant K12, K20 and the systemic clearance(CLt) of ICG were significantly(p<0.05) decreased ill the cimetidine-pretrea-to(B rats, but no significant diffirences were observed in hematocrit and liver weight. The biliary excretion rates of ICG were also decreased regardless of the route of administration in the cimetidine-pretreated rats. And also the hepatic blood flow in rats was decreased about $16\%$ by cimetidine. It may be concluded that the decreased hepatic blood flow with cimetidine mainly contributed to the decreased hepatic uptake and the decreased systemic clearance of ICG.
압연 및 용접방향이 같은 맞대기 용접강판의 하중방향에 따른 피로균열 진전특성
이용복,김성엽,오병덕,Lee Yong-Bok,Kim Sung-Yeup,Oh Byung-Duck 대한용접접합학회 2005 대한용접·접합학회지 Vol.23 No.6
Most of the welding steel plate structures have complicated mechanical problems such as rolling directional characteristics and residual stresses caused by manufacturing process. For the enhancement of reliability and safety in those structures, therefore, a systematic investigation is required. SS400 steel plate used for common structures was selected and welded by FCAW butt-welding process for this study, and then it was studied experimently about characteristics of fatigue crack propagations with respect to rolling direction and welding residual stress of welded steel plates. When the angles between rolling direction and tensile loading direction in base material are increased, their ultimate strength not show a significant difference, but yielding strength are increased and elongations are decreased uniformly. It is also shown that fatigue crack growth rate can be increased from those results. When the angles between welding bead direction and loading direction in welded material are increase, fatigue crack growth rate of them are decreased and influenced uniformly according to the conditions of residual stress distribution. In these results, it is shown that the welded steel plate structures are needed to harmonize distributed welding residual stress, rolling direction and loading direction fur the improvement of safety and endurance in manufacture of their structures.