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제3차 대한간학회 춘계학술대회 초록집 : 포스터연제 토의 ; Ethylnitrosourea에 의한 마우스 간소엽내 전암병소의 중심정맥주변구역 편향성
이동후 ( Lee Dong Hu ),김병훈 ( Kim Byeong Hun ),이숭환 ( Lee Sung Hwan ),양성규 ( Yang Seong Gyu ),조영중 ( Jo Yeong Jung ),유병무 ( Yu Byeong Mu ),정철헌 ( Jeong Cheol Heon ) 대한간학회 1997 Clinical and Molecular Hepatology(대한간학회지) Vol.3 No.2(S)
제3차 대한간학회 춘계학술대회 초록집 : Sprague-Dawley쥐에서 Diethylnitrosamine에 의한 Gamma-GTP 양성 병소의 간소엽내 문맥주변구역 분포
김홍주 ( Kim Hong Ju ),이숭환 ( Lee Sung Hwan ),박동일 ( Park Dong Il ),정철헌 ( Jeong Cheol Heon ),조용현 ( Jo Yong Hyeon ),남승우 ( Nam Seung U ),이동후 ( Lee Dong Hu ) 대한간학회 1997 Clinical and Molecular Hepatology(대한간학회지) Vol.3 No.2(S)
만성 실질성 간질환 환자 혈청에서 Basic Fibroblast Growth Factor 및 Angiogenin 농도의 변동
백인규(In Kyu Paik),이숭환(Soong Hwan Lee),조윤주(Yun Ju Cho),이성희(Sung Hee Lee),김홍주(Hong Ju Kim),남승우(Seung Woo Nam),고희관(Hee Kwan Koh),이창범(Chang Beom Lee),박동일(Dong Il Park),조영중(Yong Jung Cho) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.6
N/A Background/Aims: Liver fibrosis by the progression of the chronic process of the liver disease induces deformed microcirculations of the hepatic lobules and this eventually resulted in portal hypertension. Angiogenic stimulant factors are physiologically activated in order to repair the tissue damage. Overexpression of angiogenic factors, however, can stimulate neovascularization as in a formation of the hypervascular tumor that liberates uncontrolled overgrowing of the tumor cells. To elucidate the dynamic changes of the serum concentration of basic fibroblast growth factor(bFGF) and angiogenin in chronic liver diseases, this study is intended to employ an ELISA out of pathologically proven patients. Methods: Sera taken out of the 44 patients with chronic persistent hepatitis(5 cases), chronic active hepatitis(6 cases), liver cirrhosis(19 cases) and hepatocellular carcinoma(14 cases) were tested for bFGF and angiogenin employing Quantikine' ELISA Kits (R & D Systems Inc. Minneapolis, MN) that pathological diagnosis was proven )ater. The statistical analysis was evaluated by students t-test. Results: Serum mean value and standar<I error of bFGF concentration(pg/ml) was 11.851.98 in 19 cases of liver cirrhosis, 9.86+2.35 in 14 cases of hepatocellular carcinoma, 9.48+4.57 in 6 cases of chronic active hepatitis, and 8.29+2.63 in 5 cases of chronic persistent hepatitis. Mean value and standard error of angiogenin concentration (ng/ml) of the sera was 238.92+50.95 in 5 cases of chronic persistent hepatitis, 184.47+12.75 in 6 cases of chronic active bepatitis, 131.36+10.99 in 19 cases of liver cirrhosis, and 211.03+19.08 in 14 cases of hepatocellular carcinoma, respectively. Serum angiogenin concentration in liver cirrhosis was significantly lower than that in chronic persistent hepatitis(p=0.0033(I), and than that in chronic active hepatitis(p=0.018673). Angiogenin concentration in hepatocellular carcinoma was very significantly elevated, when compared with the level of the liver cirrhosis investigated (p=0.000569). Conclusions: These data suppoit that persistent inflammatory insults in chronic hepatitis were compensated by the elevation of angiogenin, but complete fibrosis as in liver cirrhosis showed the depressed level of angiogenin. Again, emerging of the hepatocellular carcinoma is accompanying with the elevated stitnuli of angiogenin for the neovascularization. In contrast, bFGF in this study was statistically not significant but may be related with fibrosis and reconstruction of microvascular system accompanying with progression of chronic parenchymal liver diseases to liver cirrhosis.(Korean J Gastroenterol 1996; 28:806-814)
HBV - bDNA 음성 만성 B 형 간염 바이러스 보유자의 간조직검사 소견과 임상적 특징
노병주(Byung Joo Roh),이숭환(Soong Hwan Lee),한성희(Sung Hee Han),조승철(Seung Chul Cho),손주현(Joo Hyun Sohn),이동후(Dong Hoo Lee),기춘석(Choon Suhk Kee) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Background/Aims: It is common in Korea that young men carry HBV-bDNA (branched chain DNA) negative chronic HBsAg, regardless of abnormal aminotransferases. However, histologic findings of these patients were not well-known. The authors studied histologic characteristics of hepatitis activity in these patients and assessed the correlations of aminotransferases and the histologic characteristices of hepatitis activity/fibrosis. Methods: Routine biochemical liver function tests were performed for the 29 young male HBV-bDNA negative chronic HBsAg carriers. Their histologic hepatitis activity/fibrosis was scored. Results: Ninety percent of the patients showed chronic inflammation at liver biopsy, whereas 80% of the parents who had normal aminotransferase showed chronic inflammatory feature in spite of their HBV-bDNA negativity. A significant correlation was found between the levels of aminotransferases and histologic hepatitis activity (lobular activity and portoperiportal activity). The patients with abnormal aminotransferase revealed the higher grade activity than the patients with normal aminotransferase in lobular activity and portoperiportal activity. Conclusions: Most of young male HBV-bDNA negative chronic HBsAg carriers show the histologic characteristics of chronic hepatitis. Some patients could be recovered, but others may show viral replication during their clinical course. (Korean J Gastroenterol 2001;38:419-426)