Ethanolamine Oleate 진피 내 주입술로 치료한 유아 혈관종

이숙경 ( Sook Kyung Lee ),서종근 ( Jong Keun Seo ),심현수 ( Hyun Soo Sim ),이영석 ( Young Seok Lee ),정세원 ( Se Won Jung ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.7

Infantile hemangiomas are benign vascular tumors that commonly occur in infants. The management of hemangiomas ranges from simple observation and assurance to surgical resection. The commonly used treatment modalities include topical, intralesional and systemic steroids, pulsed dye laser and surgical excision. There are several reports of infantile hemangiomas treated with direct percutaneous injections of sclerosing agents such as ethanol, polidocanol or ethanolamine oleate. We report here on a case of infantile hemangioma that was treated with ethanolamine oleate by dermal injection. We think this is the first report of a dermal injection of ethanolamine oleate, and not intraluminal injection, for treating infantile hemangioma. (Korean J Dermatol 2010;48(7):627∼630)

인간 유두종 바이러스로 인해 보웬 모양 변화를 보인 국한성 수장 저각화증 1예

정우석 ( Woo Seok Jeong ),진우정 ( Woo Jung Jin ),문승현 ( Seung Hyun Moon ),황보현 ( Hyun Hwangbo ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.8

Circumscribed palmar or plantar hypokeratosis is a rare condition characterized by the occurrence of an erythematous, well-circumscribed, and depressed macule or patch on the palms or soles. Histopathologically, it is characterized by sharp, stair-like abrupt thinning of the horny layer between the affected and unaffected skin. The pathogenesis of this condition remains unclear. Recently, the human papilloma virus has been implicated as a possible etiological contributor. Circumscribed palmar or plantar hypokeratosis usually shows a benign course. Previous reports have not described malignant changes in these lesions. However, its association with actinic keratosis has been reported in a previous case. We report a case of circumscribed palmar hypokeratosis showing bowenoid epidermal change with expression of the human papilloma virus types 6 and 16 in a patient who was successfully treated with ingenol mebutate gel and cryotherapy. (Korean J Dermatol 2018;56(8):489∼493)

통상적인 치료에 충분히 반응하지 않는 심한 급성 두드러기 환자에서 저용량 에피네프린의 지속적 정맥 내 투여 치료의 효과와 안전성에 대한 연구

정우석 ( Woo Seok Jeong ),황보현 ( Hyun Hwangbo ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.4

Background: Acute urticaria sometimes accompanies severe systemic reactions that can be potentially life-threatening. Some patients do not achieve sufficient responses to conventional treatments. There has been no previous study on the effect of continuous intravenous infusion of epinephrine in patients with severe acute urticaria. Objective: This study investigated the efficacy and safety of continuous intravenous infusion of low-dose epinephrine in patients with severe acute urticaria who did not achieve a sufficient response to conventional treatments. Methods: We retrospectively reviewed the medical records of 74 patients with severe acute urticaria who were treated with continuous intravenous infusion of low-dose epinephrine between November 2008 and December 2016. One milligram (1 mL) of 1:1000 epinephrine was diluted in 1 L of saline to yield a concentration of 1 μg/mL. The solution was infused at 0.67 μg/min (40 mL/h). Vital signs were checked at 0, 30, 60, and 90 minutes after infusion of epinephrine. Epinephrine was discontinued after one symptom-free day. Results: Clinical symptoms initially resolved within 24.8 hours on average and symptoms were completely resolved within 73.4 hours on average. Twenty-four adverse events, including palpitation, chest discomfort, hand tremor, increased blood pressure, and elevated cardiac markers, were observed in 19 patients (25.7%). Most adverse events were mild and regressed spontaneously without further management. Four patients (5.4%) stopped the infusion due to adverse events, but all events regressed spontaneously after stopping epinephrine. Six weeks after completion of intravenous infusion of epinephrine, 68 patients (91.9%) were symptom-free and six patients required antihistamines. Conclusion: This study suggests that continuous intravenous infusion of low-dose epinephrine is a safe and effective treatment in patients with severe acute urticaria who do not achieve a sufficient response to conventional treatments. (Korean J Dermatol 2018;56(4):242∼250)

부갑상선 절제술을 시행받은 환자에서 인 결합제 Sevelamer Hydrochloride로 치료한 칼시필락시스

이영석 ( Young Seok Lee ),손현호 ( Hyun Ho Son ),최준희 ( Jun Hee Choi ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.11

Calciphylaxis is a rare, but serious disorder that is usually observed in patients with renal disease and secondary hyperparathyroidism. It is characterized by the ischemic necrosis of the skin, the underlying tissue and other organs, as well as rapid vascular calcification. Prompt diagnosis and management is required because the intractable skin necrosis sometimes causes lethal sepsis. Sevelamer hydrochloride is an ion-exchanging resin that binds phosphates in the gut without increasing the calcium load. Treatment with it may lead to less vascular calcification and better survival for patients with chronic renal disease. Herein we present a case of calciphylaxis with renal failure and the patient improved after treatment with sevelamer hydrochloride therapy. (Korean J Dermatol 2009;47(11):1296~1299)

A형 보툴리눔 독소로 치료한 다발성 에크린 한선낭종

이영석 ( Young Seok Lee ),최준희 ( Jun Hee Choi ),심현수 ( Hyun Soo Sim ),진현우 ( Hyun Woo Chin ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.3

Eccrine hidrocystomas are benign tumors of the sweat glands that arise from cystic dilatation of the excretory sweat ducts. They may be solitary or multiple. Multiple lesions are observed as small papulonodules having prominent surfaces with a translucent intense bluish dome, localized predominantly to periorbital and malar areas. The diagnosis of multiple eccrine hidrocystomas is clinical, and surgery is the treatment of choice in the case of a single lesion. However, the treatment of multiple eccrine hidrocystomas is challenging and the outcome of conventional therapies varies. Botulinum toxin type-A (BTA) causes chemodenervation at the cholinergic nerve terminal of eccrine glands; accordingly our patient was given intradermal injections of BTA and the result was successful. Herein, we report a case of multiple eccrine hidrocystomas treated successfully with BTA; we believe that BTA can be a novel treatment option for this condition. (Korean J Dermatol 2011;49(3):283∼286)

Adapalene-benzoyl Peroxide Fixed-dose Combination Gel (Epiduo(R))을 이용한 경도와 중등도 여드름의 치료효과에 대한 연구

이영석 ( Young Seok Lee ),심현수 ( Hyun Soo Sim ),서종근 ( Jong Keun Seo ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.12

Background: A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for once-daily treatment of acne. It is known to be effective to reduce inflammatory and non-inflammatory lesions, but there have been no study in Korean yet. Objective: The aim of this study was to evaluate the efficacy and safety of adapalene 0.1%-BPO 2.5% fixed-dose combination gel (adapalene-BPO) for the treatment of mild to moderate severity acne in Korean. Methods: In total, 64 patients with mild to moderate severity acne were enrolled. Adapalene-BPO was applied to face once daily at night. The efficacy assessment was performed at baseline and monthly for 3 months: inflammatory lesions (IL), non-inflammatory lesions (NIL), total lesions (TL) were counted and median percentage changes of each lesion were measured for 3 months with patient satisfaction and adverse events questionnaire. Results: Of the 64 patients enrolled, 58 have completed 3-month treatments. Adapalene-BPO showed early onset of action with significant reduction in inflammatory, non-inflammatory, and total lesion counts. The median percentage reduction of mild group from baseline to 3rd month was greater than moderate group in IL, NIL, and TL counts (71.1% vs 65%/61.4% vs 56.4%/67.7% vs 62% reduction). Also, patient satisfaction score improved and significant reduction of Korea Acne Grading System (KAGS) was noted in both groups. All the reported adverse events were mild. Conclusion: This study shows that adapalene-BPO is an effective and safe treatment regimen for both mild and moderate acne. It has a better effect for treating mild severity acne than moderate acne with reduction of the IL, NIL, and TL counts and greater patient satisfaction. (Korean J Dermatol 2010;48(12):1068∼1077)

투메슨트-지방흡입술과 Pull-Through Technique으로 치료한 여성형유방

이영석 ( Young Seok Lee ),서종근 ( Jong Keun Seo ),권태광 ( Tae Gwang Kwon ),심현수 ( Hyun Soo Sim ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.8

Gynecomastia is the most common condition affecting the male breast due to enlargement of both ductal and stromal tissue. Growth of the male breast can be manifested at any age, but 40% of cases present in adolescent boys. The condition depends mainly on the balance between serum estrogens and androgens. Gynecomastia represents a source of embarrassment, and optimal correction is difficult to achieve. Numerous methods of gynecomastia repair are available. Our method is a combination of liposuction and the pull-through technique. The purpose of this treatment is to resect excess tissue and restore the normal chest contour with minimal scarring. We report a case of gynecomastia treated with a combination of tumescent liposuction and the pull-through technique. (Korean J Dermatol 2011;49(8):748∼752)

비정형 항정신병약물 복용 중인 과체중 환자에서 체중 감량을 위한 행동수정요법의 개발 - 예비연구 -

신홍범,박종호,차보석,김병수,이숙경,김학령,김용식,안용민,강웅구,Shin, Hong Beom,Park, Jong Ho,Cha, Bo Seok,Kim, Byung Soo,Lee, Suk Kyung,Kim, Hak Lyung,Kim, Yong Sik,Ahn, Young Min,Kang, Ung Gu 대한생물정신의학회 2003 생물정신의학 Vol.10 No.2

Objects:The authors devebped a behavioral modification program for oveweight outpatients with schi-zophrenia and bipolar disorder will had teen treated with atypical antipsychotics, and evaluated the applicability of this program to outpatients Methods:Two men and nine women who had been treated with atypical antipsychotics and will had gained at least 5 percent of their pre-treatment body weight for 10 weeks, attended a behavioral modification program. The patients' weight, body mass index and the diet-activity scale were assessed and were compared with those of a matched comparison group will dd not attend the behavioral modification program Results:The body weight of patients who attended the behavioral modification program reduced with statistical significance, The treatment group showed significant improvement in diet-related items but not in activity-related items of the diet-activity scale Conclusions:This study suggested the applicability of a eehavioral mcdification program on weight reduction to overweight patients taking atypical antipsychotics for the frrst time in Korea Additional large scale studies are needed to validate the effectiveness of this program.

Self-healing Juvenile Cutaneous Mucinosis 1예

문승현 ( Seung Hyun Moon ),정우석 ( Woo Seok Jeong ),이택근 ( Taek Geun Lee ),권태광 ( Tae Gwang Kwon ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.10

Self-healing juvenile cutaneous mucinosis (SHJCM) is a rare disorder of unknown origin that affects healthy children. It is characterized by multiplication of transient papules and nodules on the head and periarticular area. Histopathologically, lesions show mucin deposition in the dermis or subcutis. A 9-year-old male patient presented with multiple skin-colored papules and nodules on the face and both hands. These papules and nodules had appeared over the preceding months and had been increasing in number. He was otherwise healthy and had no underlying systemic disorders. Skin biopsy in the right thenar nodule revealed deposition of amorphous material stained positively with Alcian blue (pH 2.5) within the dermis and subcutis. Spontaneous resolution occurred over several months without sequelae. (Korean J Dermatol 2016;54(10):814∼818)

한국인에서 수장족저농포증과 흡연의 연관성에 대한 연구

손현호 ( Hyun Ho Son ),이영석 ( Young Seok Lee ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.11

Background: Palmoplantar pustulosis (PPP), a skin disease, is characterized by chronically recurring sterile pustules on the palms and the soles. Although the etiology of PPP is unknown, it is interesting to note high prevalence of tobacco use in these patients. It would seem that there may be a relationship between PPP, autoimmune disease and alterations of thyroid function. However, this fact was never verified among Korean. Objective: This study aims to explore smoking as a risk or exacerbation factor for PPP in Korean patients with PPP, and confirm the relationship between PPP and other factors, including thyroid disease. Methods: We studied a total of 109 patients (M:F=38:71) with ages ranging from 20 to 70 years, diagnosed with PPP. A control group was matched according to gender and age: 109 patients with other dermatologic problem. Patients were interviewed about tobacco use, and thyroid disease, and autoimmune diseases. The data were analyzed to determine whether there was any association between PPP and various factors. Results: The proportion of PPP patients using tobacco was much higher than that of the control group (p<0.05). Smoking was more strongly associated with PPP among women. Although there was no association between the quantity of cigarettes smoked daily and the severity of PPP, there was a dose-dependent correlation between the pack*year and the severity of PPP (p<0.05). Furthermore, 14 patients had been diagnosed with thyroid disease. In addition, all of them were smokers. Conclusion: There was significant association between PPP and smoking. However, the impact of giving it up in the clinical course of the disease remains to be established. In addition, it would seem that there may be a relationship between PPP and alteration of thyroid function. (Korean J Dermatol 2012;50(11):945∼950)