유전성 대사 질환의 분자 유전학적 진단

기창석,이수연,김종원,Ki, Chang-Seok,Lee, Su-Yon,Kim, Jong-Won 대한유전성대사질환학회 2005 대한유전성대사질환학회지 Vol.5 No.1

Inherited metabolic diseases (IMD) comprise a large class of genetic diseases involving disorders of metabolism. The majorities are due to defects of single genes that code for enzymes that facilitate conversion of various substances into others. Because of the multiplicity of conditions, many different diagnostic tests are used for screening of IMD. Molecular genetic diagnosis is the detection of pathogenic mutations in DNA and/or RNA samples and is becoming a much more common practice in medicine today. The purpose of molecular genetic testing in IMD includes diagnostic testing, pre-symptomatic testing, carrier screening, prenatal diagnosis, preimplantation testing, and population screening. However, because of the complexity, difficulty in interpreting the result, and the ethical considerations, an understanding of technical, conceptual, and practical aspects of molecular genetic diagnosis is mandatory.

건강 검진자에서 과민성 장 증후군의 빈도 및 연관 인자

황상연 ( Sang Yon Hwang ),최창환 ( Chang Hwan Choi ),이수연 ( Su Yeon Rhie ),도미영 ( Mi Young Do ),이승현 ( Seong Hyun Lee ),김형준 ( Hyung Joon Kim ),김정욱 ( Jung Uk Kim ),김재규 ( Jae Kyu Kim ),장세경 ( Sae Kyung Chang ),박실 대한소화기기능성질환·운동학회 2006 Journal of Neurogastroenterology and Motility (JNM Vol.12 No.2

목적: 우리나라에서 과민성 장 증후군의 빈도와 이와 연관된 인자를 알아보기 위하여 단일기관에서 건강 검진을 받는 사람들을 대상으로 설문조사를 시행하였다. 대상 및 방법: 2005년 3윌부터 2005년 8윌까지 관동대학교 의과대학 명지병원에서 건강 검진을 받는 사람들을 대상으로 하여, 미리 제작된 설문지를 작성하게 하였다. 설문지는 로마 기준 II를 우리말로 번역하여 질문형식으로 바꾸었으며 설사형, 변비형, 혼합형의 아형과 세부적인 증상을 확인할 수 있는 항목, 인구통계학적인 항목 등을 포함하였다. 기본적인 문진, 말초혈액검사, 혈청생화학검사, 갑상선가능검사, 대변잠혈검사, 상부소화관내시경검사, 복부초음파검사 등의 건강 검진 자료를 분석하여 기질적인 질환에 대한 평가를 하였으며, 과민성 장 증후군 발생과 연관된 인자를 분석하였다. 결과: 총 3083명의 대상자들 가운데 설문지 작성을 거부하거나 제외기준에 해당하는 사람을 제외하고 총 2,345명(76.1%)의 대상자가 연구에 포함되었다. 이 중 남자는 1,298명(55.4%), 여자는 1,047명(44.6%) 이었고 이들의 평균 연령은 49.0±13.6세였다. 로마기준 Ⅱ에 따른 과민성 장 증후군의 빈도는 8.3%였다. 증상에 따른 아형은 설사형 30.8%, 변비형 23.6%, 그라고 설사-변비 혼합형이 45.6%로 혼합형이 가장 많았다. 35세 미만의 젊은 연령에서 과민성 장 증후군의 빈도가 13.1%로 유의하게 높았고, 또한 체질량지수가 18.5 미만인 저체중에서의 빈도가 21.0%로 유의하게 높았다(p<0.01). 그러나 연령, 거주지역, 직업군, 흡연 및 음주력, 당뇨와 고혈압의 과거력, 빈혈의 유무, 혈액형, 역류성 식도염, 소화성궤양 및 지방간 유무, 그라고 헬리코박터 균 감염 유무에 따라서는 과민성 장 증후군 빈도에 차이가 없었다. 결론: 로마기준 II를 적용하여 건강 검진자를 대상으로 조사한 우리나라 과민성 장 증후군의 빈도는 8.3%이며, 35세 미만의 젊은 연령과 저체중에서 유의하게 빈도가 높았다. Background/Aims: Irritable bowel syndrome (IBS) is a common health problem affecting a substantial proportion of the population. The aims of this study were to evaluate the frequency of IBS that satisfied the ROME II criteria and to analyze the factors that could be associated with the frequency of IBS in subjects who underwent health check-ups in South Korea. Methods: We included a total of 2345 (76.1%) subjects among the 3083 subjects who visited the Health Promotion Center of Kwandong University College of Medicine, Myongji hospital from March 2005 through August 2005. They were interviewed by using a questionnaire that was comprised of the demographic features, the ROME II criteria and the probable associated factors. The frequency of IBS was analyzed according to various factors such as the demographic characteristics, the past history, the body mass indexes (BMI), blood tests and the endoscopic and abdominal sonographic findings. Results: The frequency of IBS was 8.3% (7.9% in males and 8.8% in females). Of the IBS patients, 30.8% had characteristics of diarrhea-predominance, 23.6% had characteristics of constipation-predominan while 45.6% had alternating symptoms. The most frequent symptom was a sense of incomplete evacuation (60.0%), followed by bloating or distention (54.9%), straining (36.9%), urgency (29.7%), and mucus in stool (9.2%). The frequency of IBS was significantly higher for the younger age subjects (age<35) and for the under-weight subjects (BMI<18.5), and these were the factors independently related with the presence of IBS on logistic regression analysis. The frequencies of IBS were not different in terms of gender, area of residence, occupation, smoking, alcohol intake, the diabetes mellitus and hypertension histories, anemia, ABO blood groups, Helicobacter pylori infection and the presence of reflux esophagitis, peptic ulcer or fatty liver disease. Conclusions: The frequency of IBS was 8.3%, according to the ROME II criteria, in the subjects who underwent health-check ups in our region. IBS was more common in the younger age subjects and the under-weight people. (Kor J Neurogastroenterol Motil 2006;12:136-143)

재식밀도가 수출오이 품질에 미치는 영향

서명훈(Seo Myeong-Whoon),이수연(Lee Su-Yon),이성재(Lee Seong-Jae),김영식(Kim Young-sik) 한국원예학회 1998 원예과학기술지 Vol.16 No.3

장애인 근로자의 직무 스트레스와 직무만족

양지숙(Yang Ji Sook),이수연(Lee Su Yon),금현섭(Kum Hyun Sub) 서울행정학회 2011 한국사회와 행정연구 Vol.21 No.4

This study aims to analyze the relationship between job stress and job satisfaction of disabled employees. Especially, it examines whether social support including specific aids or services from others moderates the impact of job stress from work environment, role demand, and organizational justice on job satisfaction. The empirical results based on the data from Panel Survey of Employment for the Disabled(PSED) during the years of 2008 to 2009 show that social supports could alleviate or exacerbate the impact of job stress on job satisfaction while job stress itself has negative effects. These bifurcated effects of social support depend on the type of job stressors: for instance, social support seems to have buffering effect when the stress stems from work environment while reverse-buffering effect is found when the stress is related to the role demand and organizational justice. This suggests that it is important to consider the sources of job stress when social support is designed and provided in order to increase the job satisfaction of disabled employees.

암꽃제거 절위가 수출오이 품질에 미치는 영향

서명훈(Seo Myeong-Whoon),이수연(Lee Su-Yon),이성재(Lee Seong-Jae),김영식(Kim Young-sik) 한국원예학회 1998 원예과학기술지 Vol.16 No.3

퇴계 예술철학 연구

이상곤,이수연 원광대학교 2006 論文集 Vol.37 No.-

The purpose of this thesis to consider how the thought of Toikey was applied to his poetries and becaue literature, how the thematic consciousness appeared in his each works of poetries reflected the factors of Sung Confucianism and finally how the consciousness to the life of Toikey could be characterized. In considering that originally literature should connotes not only sensual reflection or susceptible apple of things but also thought which fines and verifies the experience and possibility of the life, literature should reject the establishment of subordinate relationship to philosophy and should be existed by not bigotry of its inner correspondence. Only in such case, thinking structure is generated and it becomes characteristic appearance of consciousness obtained from the fighting with constant times and society. Toikey Lee, Hwang was a leading figure in Sung Confucianism and he was also a literary man who applied his thought to the literature. His literature is comprehensive but not indecent, has respect and justice, pursues brightness and sincerity, harmonizes knowledge and practice, matches dynamics and statics and finally unifies things and self, that is, to search for the root of human moral nature. These were recognition process and also object of universal life which the ruling ideology of the day was regarded as a conception, but these were apt to be sturdy, controlled and standardized literary aspect. But rather Toikey melted Sung Confucianism into literature through application and transmission processes of consciousness and showed the characteristics of inner world of self. That is, that all existing consciousness were reduced and ended to philosophy could be a negative factor endangering the existence basis of literature itself, but Toikey was participated in the production of poetry literature by extending it to exalted literary domain after breaking from the doctrine in the respect of the reproduction of real life. Therefore, in studying the application aspect of Toikey's poetry literature to Sung Confucianism, I set up signpost by presenting some premises.