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이성우,황방연,김세은,김환묵,김영호,이경순,이정준,노재섭,Lee, Sung-Woo,Hwang, Bang-Yeon,Kim, Se-Eun,Kim, Hwan-Mook,Kim, Young-Ho,Lee, Kyong-Soon,Lee, Jung-Joon,Ro, Jai-Seup 한국생약학회 1995 생약학회지 Vol.26 No.4
Preliminary screening test of modulators for multidrug resistance with 400 medicinal plants was carried out by using human multidrug resistance cell line, KB-V1. Among active medicinal plants, the unripe fruits of Evodia officinalis showed a potent modulating activity of MDR. From MeOH extract of this plant, we isolated two indole alkaloids, rutaecarpine (1) and evodiamine (2), by repeated silicagel column chromatography. Rutaecarpine increased the cytotoxicities of vinblastine and taxol against multidrug resistance cells, but evodiamine showed no modulating activity in spite of its potent cytotoxic activities.
이성우,최성혁,홍윤식,김수진,문성우,문준동,정상헌,박종수,Lee Sung Woo,Choi Sung Hyuk,Hong Yun Sik,Kim Su Jin,Moon Sung Woo,Moon Jun Dong,Jung Sang Hyun,Park Jong Su 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.1
Diagostic imaging can help in management of toxicologic emergencies. We report a patient who presented to the emergency department with coma and suppressed respiration after ingestion of unknown substance. We documented chloroform with radiopaque material in bowel on abdominal radiograph. We used activated charcoal and laxative to decontaminate bowel. Hepatotoxicity occurred on 3rd admission day and elevation of liver enzyme reached peak level on 5th admission day. The patient received hemoperfusion, N-acetylsystein and supportive cares. The patient was improved from hepatic dysfunction and discharged without complication on 11th admission day. Radiograph in toxicology may confirm a diagnosis and assist in therapeutic intervention.
이성우,홍기증,Lee, Sung-Woo,Hong, Kee-Jeung 한국전산구조공학회 2006 한국전산구조공학회논문집 Vol.19 No.4
본 연구에서는 개발된 중공단면 복합소재 교량 바닥판에 대해 피로거동을 평가하기 위하여 거더 지지부에서의 압축피로 시험과 2.8m 길이의 휨시험체 모델에 대한 휨피로시험을 수행하였다. 피로하중은 도로교설계기준의 제시된 DB24 트럭 후륜 축하중에 대해 200만회까지 반복 재하하였으며, 압축피로시험의 경우에는 복합소재 바닥판 부재와 바닥판 튜브간의 연결부에 대한 피로성능을, 휨피로시험의 경우에는 복합소재 바닥판 및 주형연결부에 대한 피로성능을 분석하였다. In this study, to evaluate fatigue characteristics of developed composite bridge deck, compression fatigue test at girder support and flexural fatigue test for the 2.8m-long flexural test model were carried out. For the test specimen, DB 24 truck load was applied up to 2,000,000 cycles. In the compression fatigue test, behavior at deck tube and its bonded connection were evaluated. In the flexural fatigue test, deck behavior at mid-span and girder connection were evaluated.