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이선학(Sun Hak Lee),김용익(Yong Ik Kim),김진수(Jin 대한통증학회 1997 The Korean Journal of Pain Vol.10 No.1
N/A Background: There are several treatment of trigeminal neuralgia including Gasserian Ganglion Block. This paper retrospectively analyze the efficacy of Gasserian Ganglion Block as main treatment of trigeminal neuralgia. Methods: We studied 55 patients for followings; sex, age, duration from onset to visit, consulted mediator, causes, characteristics of pain, affected area, types of block, kinds and volume of used neurolytic agents, duration from first block to repeat block, types of repeat block, complications, if surgery was necessary after block Results: Charcteristic items of trigeminal neuralgia are similar with other studies. Mean duration of pain relief was 23 months. The duration was shortened in the repeat block. There were no significant complication. Conclusion: Considering Gasserian Ganglion Block as main treatment of trigeminal neuralgia is an effective and safe method. Therefore we would like to recommend the need to increase public awareness of trigeminal neuralgia and its possible treatment in pain clinics through mass commanication.
저병원성 조류인플루엔자 감염에 따른 육계의 면역인자 변화
김덕환(Deok-Hwan Kim),김규직(Kyu-Jik Kim),노진용(Jin-Yong Noh),이선학(Sun-Hak Lee),송창선(Chang-Seon Song),박혜경(Hae Kyoung Park),남상섭(Sang-Soep Nahm) 한국가금학회 2020 韓國家禽學會誌 Vol.47 No.4
가금산업에서 전염성 질병은 농장의 생산성에 악영향을 미치는 중요한 요인이다. 그 중 저병원성 조류인플루엔자는 산란율과 증체율에 영향을 준다. 본 연구에서는 육계에서 저병원성 조류인플루엔자 감염시 혈청 단백질 및 사이토카인의 변화 양상을 조사하였다. 1일령의 육계를 1주령부터 4주령까지 각 주령마다 저병원성 조류인플루엔자를 공격 접종 후 혈중 chDBP, Chicken Ovotransferrin, chIL-1β, chIL-6, chIFN-γ의 양을 비교하였다. 어린 주령에 저병원성 조류인플루엔자를 공격접종한 그룹에서는 4주령에 음성대조군과 비교해 chIL-1β, chIL-6가 유의성 있는 낮은 값을 보이는 것을 확인하였다. 추가적인 연구를 통하여 chIL-1β, chIL-6가 질병의 경과를 확인할 수 있는 보조적인 감염 지표로 활용될 수 있을 것으로 판단된다. Avian influenza virus infection, one of the most important diseases recognized in the poultry industry, is known to cause changes in cytokine and serum protein levels. However, the normal ranges and/or age-dependent changes in important cytokines and serum proteins associated with influenza infection have not been fully elucidated. In this study, the levels of cytokines (interleukin-1β, interleukin-6, and interferon-γ) and serum proteins (vitamin D binding protein and ovotransferrin) were determined in 1-week- to 4-week-old broilers at 1-week intervals after challenge with a low pathogenic influenza virus. The results showed that the physiological levels of cytokines and serum proteins varied with aging during the 4 weeks. The levels of interleukin-1β and interleukin-6 increased from 20% to 35% after influenza infection compared to those in the negative control group, indicating that these cytokines may be used to monitor disease progression.
Cu 치환에 따른 Ni-Zn 페라이트의 전자파 흡수 특성
오영우,이선학,김종령,안용운,이승관 경남대학교 신소재연구소 2001 신소재연구 Vol.13 No.-
고상반응법을 이용하여 Ni_0.6-xCuZn_0.4Fe _2O_4(x=0, 0.1, 0.2, 0.3) ferrite 분말을 제조하고 1200℃에서 열처리하여 Cu 치환에 따른 입자변화와 전자파흡수 특성과의 관계를 조사하였다. Ni 자리에 Cu를 0.1mol 치환했을 때는 포화자화값은 큰 변화 없이 일정하였고 우수한 전자파습수능을 나타내었고, 그 이상 첨가 시는 포화자화값과 전자파흡수능은 직선적으로 감소하였다. Ni_0.6-xCuZn_0.4Fe _2O_4 ferrite powder was prepared by the solid-reaction method and sintered at 1200℃ and investigated grain size related with electromagnetic wave absorbing properties were investigated as a function of Cu substitution. The saturation magnetization and electromagnetic wave absorbing efficiency were rarely changed until substitution of Cu 0.1mol into Ni-site, but decreased strongly over 0.1mol Cu,
흰쥐 횡격막 신경근 표본에서 Decamethonium 이 d-Tubocurarine 의 작용에 미치는 영향
이정석,송주은,김성열,이선학,박욱,황경호 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.34 No.5
Background : To elucidate the mechanism of interaction between depolarizing and nondepolarizing muscle relaxants, train-of-four (TOF) fade during onset of neuromuscular blockade of d-tubocurarine (dTC) with or without decamethonium (C10) was evaluated in a rat phrenic nerve hemidiaphragm preparation. Methods : Phrenic nerve hemidiaphragm preparations from 250∼300 g Sprague Dawley rats (n=20) were suspended in a Krebs solution bubbled with 5% CO2 in O2 at 32oC. Phrenic nerves were stimulated with supramaximal stimuli of 0.2 ms duration at 0.15 Hz single twitch and 2 Hz TOF by a Grass S88 stimulator and the contractions of the hemidiaphragm were detected by a Grass FT03 force transducer then recorded. Estimation of ED50 for the dose response data were performed by a linear regression. The statistical significance of the results was determined by Wilcoxon Rank Sum test. P$lt;0.05 was considered significant. Results : Mean ED50 values of dTC and C10 calculated from the dose response relations were 7.76 g/ml and 0.5 g/ml respectively. Compared to adminstration of 2×ED50 of dTC alone, TOF ratios at 75% and 50% of twitch height were markedly decreased by combination of ED50 of C10 and ED50 of dTC with statistic significance (67±1.9% vs. 46±3.1% and 36±2.5% vs. 7±2.5%). Conclusion : If fade in response to TOF stimulation represents a prejunctional effect, the results from this study suggests that the presynaptic action of C10 has some role in the mechanism of the interaction between dTC and C10 in the rat. (Korean J Anesthesiol 1998; 34: 910∼914)
누두흉환자에서 Nuss 방법에 의한 수술 중 환기방법에 따른 호기 일회호흡량, 흡기 최대압력 및 활력징후의 변화
조수현,이선학,안기량,박욱,박형주,곽수달,백남순,김천숙 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.2
Changes of Vital Signs, Expired Volume and Maximal Pressure by Mode of Ventilation during a Nuss Operation in Patients with Pectus Excavatum Soo Dal Kwak, M.D., Nam Soon Baek, M.D., Su Hyun Cho, M.D. Ki Ryang Ahn, M.D., Sun Hak Lee, M.D., Chun Suk Kim, M.D. Wook Park, M.D., and Hyung Joo Park, M.D. Departments of Anesthesiology, ??Chest Surgery, College of Medicine, Soonchunhyang University, Cheonan, Korea Background: This study was undertaken in order to investigate any cardiopulmonary changes caused by the surgical procedure during a Nuss operation in patients with pectus excavatum. Methods: Thirty patients undergoing the Nuss operation were divided into two groups. The patients were randomly assigned to either Group-V (n = 15) which volume controlled ventilation was applied, or to Group-p (n = 15) where pressure controlled ventilation was applied. Mechanical ventilation provided a tidal volume to be set at approximately 10 ml/kg and a frequency set to keep ETCO_2 in range, between 32 mmHg and 38 mmHg. During the surgical procedure, we recorded expired volume (V_E) and inspired maximal pressure (Pmax) changes according to the ventilator mode, and then also recorded changes in vital signs. Results: Heart rate and blood pressure had no significant changes in either groups. In Group-V, during rotation of the metal bar, there was a significant decrease in expired volume (P < 0.001), changes of inspired maximal pressure gradually increased with the operation (P < 0.001). In Group-P, rotation of the metal bar caused a significant decrease in expired volume (P < 0.001). Conclusions: During the Nuss operation, there should be careful observation of changes in the vital signs, expired volume and maximal pressure during insertion and rotation of the metal bar. (Korean J Anesthesiol 2001; 41: 178~183)
Etomidate, Propofol 및 Thiopental Sodium을 이용한 마취 유도 시 안압에 미치는 영향
김상현,김진수,이선학,김천숙,심세홍,곽수달,안기량 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.39 No.3
Background: During ophthalmologic surgery, a variety of anesthetic induction techniques are used in an attempt to prevent the rise of intraocular pressure (IOP). This study compared the effects of etomidate, a new intravenous anesthetic agent, on the changes in IOP with those of thiopental sodium and propofol. Methods: Forty-five patients were randomly allocated and divided into three groups to be injected intravenously with etomidate 0.2 0.3 mg/kg (E-group, n = 15), propofol 2 3 mg/kg (P-group, n = 15) or thiopental sodium 4 - 5 mg/kg (T-group, n = 15). Systolic arterial pressure (SAP), heart rate (HR) and intraocular pressure (IOP) were measured at 1, 2 and 3 minutes after the administration of the induction agents. During the induction of anesthesia, the incidence of IV injection pain, myoclonus, hiccup and a decrease in SAP of more than 30% were investigated. Results: At 1, 2 and 3 min following the induction of anesthesia, the SAP in the P-Group decreased significantly more than that in the other two groups (P $lt; 0.05). After the induction, heart rate in the T-Group increased significantly more than that in the other two groups (P $lt; 0.05). The three intravenous agents induced a significant decrease in IOP after an injection (P $lt; 0.05). Comparing the three groups, the IOP in the E- and P-Group decreased significantly more than that in the T-Group (P $lt; 0.05). Conclusions: Etomidate may be used as a choice of intravenous induction agent to reduce intraocular pressure in ophthalmologic operations especially in an emergency situation, geriatric and hypovolemic patients.