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NaF CPC 녹차추출액 및 솔잎 추출물을 배합한 구강양치액의 치주질환예방효과와 구취감소효과 및 치아우식증예방효과에 관한 연구
배광학,이병진,장윤경,이병렬,이원재,장덕수,문혁수,백대일,김종배 대한구강보건학회 2001 大韓口腔保健學會誌 Vol.25 No.1
The aim of this study was to assess the effect of mouthrinse products which contained 0.03% sodium fluoride, 0.05% cetylpyridinium chloride(CPC), 0.04% pine leaf extracts and 0.04% green tea extracts. The negative control was distilled water contained no antibacterial agents. The in vivo study used case control, double-blind and crossover design in which 40 healthy subjects aged from 20 to 25 participated. On baseline, subjects received a scaling and polishing to reduce plaque index to 0 and commenced rinsing three times and toothcleansing twice daily. Rinsing time was 30 seconds. Plaque, gingivitis, halitosis and the number of S. mutans(CFU/㎖) were scored at baseline, after 2 weeks, after 4 weeks and after 6 weeks. Plaque and gingivitis were score by index and halitosis by halimeter. To compare the microhardness data of differently stored enamel surfaces the in vitro study used pH Cycling Model. Each 19 bovine enamel specimens were given 17h demineralization, 0.25h immersion in mouthrinse products and control, and 6h remineralization buffer solution for 48h and 96h. Gingivitis, halitosis and S. mutans growth of the mouthrinse group were more reduced significantly than control group at 2 weeks(p<0.05). The microhardness of enamel surfaces were also more decreased in mouthrinse products than in distilled water(p<0.05).