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부인과 악성종양 환자에서 복합 항암화학요법에 따른 세포독성에 대한 Amifostine 의 임상효과에 관한 연구
이린화(Lynn Hwa Lee),지현준(Hyun Jun Jee),정화경(Hwa Kyung Jung),정유아(Yu A Jung),신정호(Jung Ho Shin),오희숙(Hee Suk Oh),박용균(Yong Kyun Park),허준용(Jun Young Hur),조수용(Soo Yong Chough),서호석(Ho Suk Saw) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : Amifostine (Ethyol(R)), an organic thiophosphate, has shown the ability to protect normal, but not neoplastic, tissues from the damaging effects of chemotherapy and radiotherapy in various kinds of cancers. This study was designed to determine ifostine could reduce the serious hematologic and nephrologic toxicities associated with cisplatin based combination chemotherapy in gynecologic cancer patients. Patients and Methods : Forty patients who received cisplatin-based combination chemotherapy were randomized into two groups. They received chemotherapy with or without pretreatment of amifostine before each course. The occurrence of hematologic and renal toxicities were evaluated. Stastical analysis was done by independent t-test and Chi-square test. Results : Hematologic toxicity was evaluated with nadir count of neutrophil and platelet. The nadir count of neutrophil was 2034.2±1199.20/μl in group with pretreatment using amifostine vs 1070.85±472.66/μl in control group (p<0.01). Platelet count was not statistically different. (p<0.16) Grade 3 neutropenia was observed in nine (45%) patients in pretreatment group vs four (20%) patients with control group (p<0.09). Grade 4 neutropenia occurred in one patient only in control group. Renal toxicity was evaluated by serum creatinine and creatinine clearance. Protracted serum creatinine elevation was not significant in both groups. (p<0.14) Reduction of creatinine clearance was less in patients with pretreatment (p<0.01). There were no significant side reactions in subjects using amifostine. Conclusion : Pretreatment with amifostine reduces the neutropenia and nephrotoxicity associated with cisplatin-based combination chemotherapy with gynecologic cancer patients.
자궁 경부 임신과 자궁내 임신이 동시에 발생 한 1 예
황종하(Jong Ha Hwang),신정호(Jung Ho Shin),송승훈(Sung Hun Song),오희숙(Hee Suk Oh),이린화(Lynn Hwa Lee),이미정(Mi Jung Lee),허준용(Jun Young Hur),서호석(Ho Suk Saw),박용균(Young Kyun Park),조수용(Soo Yong Chough) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12
N/A Although recently the incidence of heterotopic pregnancies are increasing because of assisted reproduction, heterotopyic pregnancies were rare with an incidence of 1 per 30,000 pregnancies. In this presentation, we describe a case of combined intrauterine and cervical pregnancy after artificial abortion. The patient was treated by local injection of methotrexate directly into gestational sac under the guidance of sonogram after systemic methotrexate treatment. The gestational products were removed by dilatation & currettage due to persistent vaginal bleeding on the next day. So we report a case with a brief review of the literatures.