급성골수성백혈병의 Adriamycin 과 Ara - C 병합요법에 의한 관해유도효과

이규보 ( Kyu Bo Lee ),황기석 ( Kee Suk Whang ),이재태 ( Jae Tae Lee ),유만준 ( Man Joon Yu ) 대한내과학회 1985 대한내과학회지 Vol.28 No.4

혈관성 발기부전의 진단을 위한 방사성핵종 음경촬영술

이규보(Kyu Bo Lee),김광원(Kwang Won Kim),하승우(Sung Woo Ha),이재태(Jae Tae Lee),황기석(Kee Suk Whang),윤여득(Yeo Deuk Yoon),박윤규(Yoo Kyu Park) 대한핵의학회 1989 핵의학 분자영상 Vol.23 No.2

N/A Vasculogenic impotence is produced by abnormalities of vascular blood supply or drainage, and is the most common cause of various organic impotences. An increasing awareness of vascular causes of impotence has resulted from development of various diagnostic tests, but precise measurement of penile blood flow is difficult. Radionuclidc penogram has been introduced recently to diagnose vasculogenic impotence. Forty-one impotent patients and 12 normal men were studied with radionuclide erection penogram using Tc-99m pertechnetate and an intracavernous injection of papaverine. We defined arteriogenic impotence as arterial index less than 0 66, and vcnogenic impotence as venous index greater than 0.09. By this criteria, the false positive ratio in normal men was 17% and the false negative ratio in radically cystectomized patients was 0%. Side effects were small purpura of the penile shaft and dull pain during injection of papaverine. The radionuclide erection penogram was noninvasive and gave a dynamic evaluation of the arterial supply, venous drainage, and blood flow in the corporeal bodies. This method should be considered as a valuable adjunct to evaluate patients with vasculogenic impotence.

자가면역성 갑상선질환에서의 혈청 Thyrotropin - Binding Inhibiting Immunoglobulin치

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),손상균(Sang Kyun Sohn),장대성(Dae Sung Jang),안병철(Byeong Cheol Ahn) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.1

N/A In order to evaluate the significance of thyrotropin-binding inhibiting immunoglobulin (TBII) in the patients with autoimmune thyroid diseases, the authors investigated 402 cases of Graves' disease and 230 cases of Hashimoto's thyroiditis comparing 30 cases of normal healthy adult at Kyung Pook University Hospital from February 1993 to August 1994. The TBII was tested by radioimmunoassay and assesed on the dynamic change with the disesase course, thyroid functional parameters, and other thyroid autoantibodies; antithyroglobulin antibody(ATAb) and antimicrosomal antibody(AMAb) including thyroglobulin. The serum level of TBII was 40.82±21.651(mean±SD)% in hyperthyroid Graves' disease and 8.89±14.522% in Hashimoto's thyroiditis and both were significant different from normal control of which was 3.21±2.571%. The frequency of abnormally increased TBII level was 92.2% in hyperthyroid Craves' disease, 46.7% in euthyroid Graves' disease or remission state of hyperthyroidism, and 23.9% in Hashimoto's thyroiditis. The serum levels of increased TBII in Graves' disease were positively correlated with RAIU, serum T3, T4, and FT4, but negatively correlated with serum TSH(each p〈0.001). The TBII in Graves' disease had significant positive correlation with serum thyroglobulin and AMAb, but no significant correlation with ATAb. In the Hashimoto's thyroiditis, the serum levels of TBII were positively correlated with RAIU, serum T3, TSH and AMAb, but not significantly correlated with serum T4, FT4, thyroglobulin and ATAb. Therefore serum level of TBII seemed to be a useful mean of assessing the degree of hyperthyroidism in Graves' disease and correlated well with thyroidal stimulation. The serum level of TBII in Hashimoto's thyroiditis is meaningful for the degree of both functionl abnormality reflecting either hyperfunction or hypofunction and the immunologic abnormality.

ECG Gated Blood Pool Scan을 이용한 심실벽 역행성 운동의 평가 - Cine Loop , Phase analysis , Paradox Image의 비교 -

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),황기석(Kee Suk Whang),정병천,전재은,정진홍(Jin Hong Chung),김광원(Gwang Weon Kim),채성철(Sung Chul Chae),박의현(Wee Hyun Park),이형우(Hyong Woo Lee) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2

N/A Sixty-four patients with paradoxical ventricular wall motion noticed both in angiocardiography or 2-dimensional echocardiography were assessed by ECG gated blood pool scan (GBPS). Endless cine loop image, phase and amplitude images and paradox image obtained by visual inspection of each cardiac beat or Fourier transformation of acquired raw data were investigated to determine the incremental value of GBPS with these processing methods for identification of paradoxical ventricular wall motion. The results were as follows:1) Paradoxical wall motions were observed on interventricular septum in 34 cases, left ventricular free wall in 26and right ventricular wall in 24. Underlying heart diseases were is chemic (23 cases) valvular(9), congenita1 heart disease (12), cardiomyopathy (5). pericardial effusion(5), post cardiac surgery(3), cor pulmonale (2), endocarditis (l) and right ventricular tumor(l). 2) Left ventricular ejection fractions of patients with paradoxical left ventricular wall motion were significantly lower than those with paradoxical septal motion (p〈0.005). 3) The sensitivity of each processing methods for detecting paradoxical wall motion was 76.9% by phase analysis, 74.6% by endless cine loop mapping and 68.4% by paradox image manipultion respectively. Paradoxial motions visualized only in phase, paradox or both images were appeared as hypokinesia or akinesia in cine loop image. 4) All events could be identified by at least one of above three processing methods, however only 34 cases (48.4%) showed the paradoxical motions in all of the three images. By these findings, we concluded that simultaneous inspection of all above three processing methods-endless cine loop, phase analysis and paradox image is necessary for accurate identification and assessment of paradoxical ventricular wall motion when performing GBPS.

복막투석환자에서의 개존된 Processue Vaginalis - 방사성핵종복막촬영술로 확진된 2예 -

이규보(Kyu Bo Lee),손상균(Sang Kyun Son),이재태(Jae Tae Lee),황기석(Kee Suk Whang),조동규(Dong Kyu Cho),고철우(Chul Woo Koh) 대한핵의학회 1989 핵의학 분자영상 Vol.23 No.2

Continuous ambulatory peritoneal dialysis (CAPD) is a well established method of treating end stage renal failure, and is commonly used as an alternative to hemodia]ysis. Several complications have been observed. These include catheter rnalfunction, abdominal and inguinal hernia, and peritonitis. A relatively frequent complication is swetling of externa] geniitalia, due to bowel fluid passing through a patent processus vaginalis. Special diagnostic procedures are necessary to dctermine the nature of the abnormality and to guide the surgical correction. We reported two cases of patent processus vaginalis in patient on CAPD proved by radionuclide peritonea1 scintiscan using Tc-99 m-tin colloid.

Thallium-201 을 이용한 세포막 Na+-K+ ATPase 활성도 측정 ; Rubidium-86 측정법과의 비교

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),손상균(Sang Kyun Sohn),이인규(In Kyu Lee) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.2

N/A Purpose: Na+-K+ ATPase Activity has beem estimated by the degree of inhibition of cation transport by cardiac glycosides (ouabain) using Rb-86 as a substrate. The biological characterist- Isc of T1-201 is known to be simiIar to those of potassium as a transport substrate in the presence of glucose, insulin or phobol myristate acetate (PMA). The purpose of this study was to measure ouabain sensitive Na+-K+ ATPase activity using T1-201 and compare with that using Rb-86. Materials and Methods: Smooth muscle cells isolated from rat aorta or human placental umbilical artery were cultured, and used to measure cellular Na+-K+ ATPase activity. Na+-K+ ATPase activity was measured as a percentage decrease in cellular uptake of T1-201 or Rb-86 by ouabain under the presence of glucose, insulin or PMA in media. Results: Na+-K+ ATPase ase activity measured with T1-201, as a transport substrate, was not different from those measured with Rb-86 in rat or human smooth muscle cell preparation. Incubation with high concentration glucose resulted in about 30% decrease in enzyme activity. In contrast, insulin or PMA resulted in 50-70% or 28% increases from baseline activity, respectively. Conclusion: These results suggests that T1-201 could replace Rb-86 in measurement of ouabain sensititive Na+-K+ ATPase activity in vitro. High level of glucose concentration decreased cellular Na+-K+ ATPase activity, but insulin or PMA increased it.

심근관류 스캔중에 나타난 Thallium - 201의 심장외 국소적 섭취

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),정병천(Byung Cheon Chung),최정일(Chung Il Choi),곽동석(Dong Suk Kwak),박무근(Moo Keun Park) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1

N/A Myocardial perfusion imaging with 201T1-chloride following exercise or vasodilator-induced hyperemia has been effective in detecting the presence of coronary artery disease. An increased lung uptake of thallium has been reported as a sensitive marker of severe and extensive coronary artery disease and associated with poor prognosis. Thallium has also been noted to concentrate in a variety of malignant lesions. We report 5 cases of extracardiac uptake of thallium during myocardial perfusion scan with pharmacologic vasodilation. Accumulation of thallium was found in the lesions of a breast cancer, a lung cancer, a Castleman's disease and 2 cases of thymoma. We believe that the presence of focal extracardiac uptake of thallium during myocardial perfusion scan should suggest the need for further clinical evaluation to detect the tumor and must differentiate the increased lung uptake of thallium due to left ventricular dysfunction in coronary artery disease.

K - 통로개방제가 배양심근세포와 생쥐 체내의 Thallium - 201 역동학에 미치는 영향

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),안병철(Byeong Cheol Ahn),김은지(Eun Ji Kim),손상균(Kang Kyun Sohn),하정희(Jeoung Hee Ha),김천기(Chun K . Kim) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.4

N/A Background: Potassium channel opener (K-opener) opens ATP-sensitive K+-channel located at membrane and induces potassium efflux from cytosol, resulting in intracellular hyperpolarization. Newly synthesized K-opener is currently examined for pharmacologic potency by means of rubidium release test from smooth muscle strip pre-incubated with Rb-86. Since in-vive behavior of thallium is similar to that of rubidium, we hypothesized that K-opener can alter T1-201 kinetics in vivo. Purpose: This study was prepared to investigate the effects of pinacidil (one of potent K-openers) on the T1-201 uptake and clearance in cultured myocyte, and in-vivo biodi- stribution in mice. Methods: Spontaneous contracting myocytes were prepared to imitate in-vivo condition from 20 hearts of 3-5 days old Sprague-Dawley rat and cultured for 3-5 days before use (5×105 cells/ml). Pinacidil was dissolved in 10% DMSO solution at a final concentration of 100nM or 10uM and was co-incubated with T1-201 in HBSS buffer for 20-min to evaluate its effect on cellular T1-uptake, or challenged to cell preparation pre-incubated with T1-201 for washout study. Two, 40 or 100μg of pinacidil was injected intravenously into ICR mice at 10 min after 5μCi T1-201 injection, and organ uptake and whole body retention rate were measured at different time points. Results: Co-incubation of pinacidil with T1-201 resulted in a decrease in T1-201 uptake into cultured myocyte by 1.6 to 2.5 times, depending on pinacidil concentration and activity of T1-201 used. Pinacidil enhanced T1-201 washout by 1.6-3.1 times from myocyte preparations pre-incubated with T1-201. Pinacidil treatment appears to be resulted in mild decreases in blood and liver activity in normal mice, in contrast, renal and cardiac uptake were mildly decreased in a dose dependent manner. Whole body retention ratios of T1-201 were lower at 24 hour after injection with 100μg of pinacidil than control. Conclusion: These results suggest that treatment with K-opener may affect the interpretation of T1-201myocardial images, due to decreasing thallium accumulation and enhancing washout from myocardium.

관해된 급성 골수성 백혈병 환자에서 발생한 과립성 육종의 67Ga - citrate Scan 소견

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),황기석(Kee Suk Whang),김광원(Gwang Weon Kim),정병천(Byung Cheon Chung) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2

N/A A case of a 39-year-old man with granulocytic sarcoma documented by positive Ga-67 scan is described and brief review of literature was performed. He was diagnosed as acute myelogenous leukemia and got complete remission with antileukemic chemotherapy for 7 months. On admission, picture of his bone marrow and peripheral blood showed remission state of leukemia. Radiologic examinations were performed for evaluation of lesions in head and chest, and findings of granulocytic sarcoma were suspected. So we got 67Ga-citrate scan and pleural biopsy for identification of causes of intractable pleural effusion and skin lesion. Myeloblastomas (or granular sarcomas) proved by pleural biopsy were correctly identified by 67Ga-citratre scan, and disease extent was clearly delineated. We believe that 67Ga-scintigraphy is very helpful in localizing and follow-up evaluation of granulocytic sarcoma.

관상동맥 질환에서의 Adenosine 부하 99mTc - MIBI 심근 스캔의 진단적 가치 : 운동 부하 99mTc - MIBI 심근 스캔과의 비교

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),박의현(Wee Hyun Park),정병천(Byung Cheon Chung),최정일(Chung Il Choi),전재은(Jae Eun Jun),채성철(Sung Chull Chae),강승완(Seung Wan Kang),우언조(Eon Jo Woo) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1

N/A Pharmacologic coronary vasodilation in conjunction with myocardial scintigraphy has become an accepted alternative to dynamic exercise testing for the diagnosis of coronary artery disease. Although dipyridamole has traditionally been used for this purpose, it causes frequent side effect, which at times can be life-threatening. Moreover, dipyridamole dose not elicit maximal coronary vasodilation in a substantial number of patients receiving the usual i.v. dose. Adenosine is an endogenously produced compound that has significant effects as a coronary vasodilator and rapid onset action and extremely short half-life ((10 seconds). The diagnostic accuracy and safety profile of adenosine Tc-99m-MIBI myocardial scintigraphy were evaluated and comparison with exercise Tc-99m-MIBI was performed. Twenty-eight subjects underwent Tc-99m-MIBI imaging after adenosine infusion and exercise Tc-99m-MIBI imaging. Adenosine was infused intravenously at a dose of 0.14 mg/kg/body weight per minute for 6 min and MIBI was injected at 3 minute. Adenosine caused an incerease in heart rate (64±12 at baseline versus 74±16 beats/min at peak effect, p〈0.001), a mild decrease in systolic and diastolic blood pressure and a slightly increase in PR interval(p; NS). Side effects were reported in 92% of patients and were mostly mild in nature and promptly resolved within 1 or 2 minutes of termination of adenosine infusion. Facial flushing (53%), chest pain (36%), mild dyspnea (39%), headache (21%), throat discomfort (21%) were frequent symptoms. ST segment depression(〉1mm) and second degree AV block in electrocardiography occured in 11% of thepatients, respectively. The overall sensitivity and specificity for individual coronary stenoses in 16 patients underwent coronary angiography were 88% and 95%, respectively. The agreement ratio of segmental perfusion between adenosine and exercise images was 92% (Kappa index=0.82). In conclusion, Tc-99m-MIBI myocardial perfusion scintigraphy with intravenous adenosine is a feasible, safe and highly accurate noninvasive technique for the detection of coronary artery disease and results are at least comparable with those of exercise Tc-99m-MIBI scintigraphy.