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백서의 척수강 내로 투여한 Metabotropic Glutamate 수용체 약물의 항침해효과 및 Morphine과의 상호작용
최정일 ( Jeong Il Choi ),이형곤 ( Hyung Kon Lee ),정성태 ( Sung Tae Chung ),김창모 ( Chang Mo Kim ),배홍범 ( Hong Beom Bae ),김석재 ( Seok Jai Kim ),윤명하 ( Myung Ha Yoon ),정성수 ( Sung Su Chung ),정창영 ( Chang Young Jeong ) 대한통증학회 2005 The Korean Journal of Pain Vol.18 No.1
임상연구 : 갑상선 수술 환자에서 마취 방법에 따른 수술 후 구역과 구토의 비교
최철훈 ( Cheol Hun Choi ),정성욱 ( Seong Wook Jeong ),정성태 ( Sung Tae Chung ),배홍범 ( Hong Beom Bae ),최정일 ( Jeong Il Choi ),정성수 ( Sung Su Chung ),유경연 ( Kyung Yeon Yoo ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.4
Background: The aim of this study was to compare the anesthetic techniques for preventing postoperative nausea and vomiting (PONV) in the patients undergoing thyroidectomy. Methods: Sixty patients of ASA status I or II, undergoing thyroidectomy were studied. Patients were allocated randomly to one of three groups. Group 1 (n = 22): anesthesia was induced by propofol (2 mg/kg) and maintained with desflurane and 50% nitrous oxide in oxygen. Group 2 (n = 22): anesthesia was induced and maintained propofol and alfentanil using a computer controlled infusion system in 60% medical air in oxygen. Group 3 (n = 16): anesthesia was induced propofol using computer controlled infusion system in combination 50% nitrous oxide in oxygen. The incidence of PONV was assessed at 6 and 24 hours after the surgery and standardized by Rhodes index of nausea, vomiting and retching (RINVR) score. Results: In group 3, the incidence of PONV within the first 6 hours after surgery, was significantly lower as P < 0.05. But, there was no statistical differences among the three groups in the 6 to 24 hours` RINVR score after surgery. Conclusions: The use of propofol for induction and maintenance with combination 50% N2O is the most effective technique at preventing PONV among the three groups within the first 6 hours after thyroidectomy. This study found no statistically significant difference between the RINVR score, using desflurane-N2O and propofol-alfentanil. (Korean J Anesthesiol 2006; 51: 449~54)
심근관류 스캔중에 나타난 Thallium - 201의 심장외 국소적 섭취
이규보(Kyu Bo Lee),이재태(Jae Tae Lee),정병천(Byung Cheon Chung),최정일(Chung Il Choi),곽동석(Dong Suk Kwak),박무근(Moo Keun Park) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1
N/A Myocardial perfusion imaging with 201T1-chloride following exercise or vasodilator-induced hyperemia has been effective in detecting the presence of coronary artery disease. An increased lung uptake of thallium has been reported as a sensitive marker of severe and extensive coronary artery disease and associated with poor prognosis. Thallium has also been noted to concentrate in a variety of malignant lesions. We report 5 cases of extracardiac uptake of thallium during myocardial perfusion scan with pharmacologic vasodilation. Accumulation of thallium was found in the lesions of a breast cancer, a lung cancer, a Castleman's disease and 2 cases of thymoma. We believe that the presence of focal extracardiac uptake of thallium during myocardial perfusion scan should suggest the need for further clinical evaluation to detect the tumor and must differentiate the increased lung uptake of thallium due to left ventricular dysfunction in coronary artery disease.
당뇨병 환자의 위배출능 : 위배출시간 , 위저류율 및 Cisapride의 영향
이규보(Kyu Bo Lee),이재태(Jae Tae Lee),정병천(Byung Chun Chung),최정일(Chung Il Choi),김보완(Bo Wan Kim),곽동석(Dong Suck Gwak),정준모(Jun Mo Chung) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.2
N/A Gastic emptying scan in diabetic patients is widely used to assess the degree of motility disturbance and the symtoms such as nausea, vomiting, bloating, abdominal pain and early gastric fullness which we can't find anatomic lesion by fiberoscopic or barium study. In order to determine the relationship among diabetic gastropathy, neropathy, retinopathy and disease duration, gastric emptying scan using Tc-99m-tin colloid labeled scramble egg in hamburger was performed in 10 healty male controls and 50 diabetic patients which were subdivided to no neuropathy, peripheral neuropathy and autonomic neuropathy groups according to the degree of diabetic neuropathy and no retinopathy, background retinopathy and proliferative retinopathy groups according to the degree of diabetic retinopathy. After medication of cisapride for 2 weeks, we observed the presence of improvement of gastric motility in diabetics. The results were as following: 1) In controls, gastric emptying time (GET1/2) was 75±13.6 min and 2 hour gastric retension rate(GRR2) was 32±11.1%. 2) In diabetics, GET/2 was prolonged more than 2 hours and GRR2 was 58±23.1%. According to degree of neuropathy, GET1/2 was prolonged more than 2 hours in all three groups and GRR2 was 54±24.1% in no neuropathy group, 57±24.3% in peripheral neuropathy group and 69±24.6% in autanomic neuropathy group. According to degree of retinopathy, GET1/2 was 110±23.4 min in no retinopathy group and prolonged more than 2 hours in other two groups and GRR2 was 45±21.6% in no retinopathy group, 71±19.7% in background retinopathy group and 73±21.5% in proliferative retinopathy group. 3) After cisapride for 2 weeks, GET1/2 and GRR2 were improved as 90±14.6 min and 40±13.8% (initial GET1/2 and GRR2 were above 2 hours and 61±15.4%). We can conclude from above findings that gastropathy in diabetic neuropathy suggesting main underlying factor in motility disorder. The degree of retinopathy and disease duration were correlated with severity of gastropathy in diabetics. From the results of gastric emptying scan, we can conclude that cisapride was useful drug for improving diabetic gastropathy and gastric emptying scan was valuable for assessing severity of diabetic gastropathy as non-invasive method.
이규보(Kyu Bo Lee),이재태(Jae Tae Lee),정병천(Byung Cheon Chung),최정일(Chung Il Choi),곽동석(Dong Suk Kwak),전석길(Seok Kil Zeon),김정균(Jeong Gyun Kim),배선근(Sun Kun Bae),이형우(Hyung Woo Lee) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.1
N/A In order to evaluate the scintigraphic features of choledochal cyst and these diagnostic value, authors investigated the findings of fourteen patients with choledochal cyst undergone hepatobiliary scan with Tc-99m-DISIDA before surgery. Five cases demonstrated the decreased hepatic uptake at 5-minute image of which four cases revealed severe jaundice. Seven cases demonstrated visualization of the cystic dilated common bile duct within 1 hour after injection. Two cases showed the cyst activity between 1 and 12 hour, but the cyst activity was not visible in five cases. Nonvisualization of the gall bladder was noted in ten cases, while four cases demonstrated visualization of the gall bladder within 1 hour. The time of visualization of gut activity was variably delayed. The intestinal activity was found in three cases within 1 hour and appeared in three cases between 1 and 2 hours and eight cases showed no visible gut activity. In four cases, intrahepatic ductal prominence was visible on the scintigram. Seven cases showed early and persistent accumulation of tracer in the common bile duct. Three cases showed persistent photon-deficient area in the gall bladder region. Two cases showed early photon-deficient area around gall bladder region with progressive accumulation of tracer in the same region. Two cases showed no evidence of activity in the biliary tract but noted late excretion into the sma11 intestine. We concluded that hepatobiliary scan using Tc-99m-DISIDA is a noninvasive test useful in the eva1uation and the diagnosis of choledochal cyst.
임상연구 : Remifentanil과 Lidocaine이 Sevoflurane 마취유도 시 기관내삽관에 필요한 흡입시간에 미치는 영향
이재담 ( Jae Dam Lee ),정창영 ( Chang Young Jeong ),최정일 ( Jeong Il Choi ),이형곤 ( Hyung Gon Lee ),정성태 ( Sung Tae Chung ),김웅모 ( Woong Mo Kim ) 대한마취과학회 2008 Korean Journal of Anesthesiology Vol.55 No.5
Background: This study was conducted to investigate the optimal time interval for tracheal intubation and the effect of adjuvant drugs such as remifentanil and lidocaine during induction and tracheal intubation using sevoflurane inhalation without muscle relaxant. Methods: This study enrolled patients with the age of 20-60 years old and ASA 1 or 2. Patients were randomly assigned into one of 4 groups (S, SR, SRL, SL), in which they were given remifentanil (R) i.v. at a rate of 0.25 μg/kg/min, or lidocaine (L) i.v. bolus of 1.5 mg/kg during sevoflurane inhalation (S). Anesthesia was performed as inhalation induction 2 minutes after pre-filling with sevoflurane 8 vol%. The time interval between induction and tracheal intubation was determined using up-and-down method. When satisfied all of the categories of response to tracheal intubation, the case was assigned to `success`, otherwise `fail`. In each groups, effective time for successful intubation in 50% (ET50) and 95% (ET95) were calculated by probit analysis. Results: ET50 was 3.90 minutes (95% confidence interval 3.32-4.38) in group S, 3.18 minutes (2.92-3.48) in group SL, 2.83 minutes (2.47-3.07) in group SR, and 2.68 minutes (2.37-2.95) in group SRL. In group S, SL, SR, and SRL, ET95 was 4.52 minutes (4.17-7.95), 3.63 minutes (3.37-4.97), 3.30 minutes (3.06-4.64), and 3.12 minutes (2.89-4.42), respectively. Conclusions: The optimal time to intubate successfully using sevoflurane without muscle relaxant in 95% patients was 4.5 minutes. The optimal time is reduced to 3.1 minutes by coadministration of remifentanil and lidocaine. (Korean J Anesthesiol 2008;55:565~9)