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        인슐린 비의존형 당뇨병환자의 사망원인에 대한 고찰

        김종훈(Jong Hoon Kim),최익수(Ik Soo Choi),김천환(Cheon Whan Kim),구호성(Ho Seong Ku),손성표(Seong Pyo Son),이광재(Kwang Jaw Lee),정철호(Cheol Ho Jeong),최신영(Shin Young Choi),김인주(In Joo Kim),김용기(Yong Ki Kim),강도영(Do Young Ka 대한내과학회 1996 대한내과학회지 Vol.50 No.4

        N/A Objectives: The morbidity and mortality of diabetes mellitus have increased with the improvement of our economy. To these days, there is no report on the cause of death associated with NIDDM in Korea, but it has been generally accepted that infection may be the leading cause of death in NIDDM patients. But recently, with the improvement of infection control technique and the clinical application of new effective antibiotics, it is suspected that the death due to infection is decreasing. And, due to improvement of skill of diabetic control, the life expectancy of the diabetics has been increased. So, we hypothesized that macrovascular diseases complicated with Diabetes Mellitus may play central role in death of diabetics, resembling in developed country. In this study, we try to confirm this hypothesis. Methods: We analysed the cause of death of 149 NIDDM patients on the basis of death certificates from major hospitals in Pusan, Korea. We compared the major cause of death such as cardiovascular disorder and infection with those of general population on the basis of the 1992's statistical mortality analysis. Results: 1) In the decreased 149 Non-insulin dependent diabetics, death from cerebrovascular disease was 24.8% (37/149), infection was 24.2% (36/149), ischemic heart disease was 12.8% (12/149), congestive heart failure was 9.4% (14/149). Death due to diabetic metabolic complications, liver disease, malignant tumor and renal failure were 6.0%, 5.4%, 4.7% and 3.3% respectively. 2) When we compared the major cause of death of non-insulin-dependent diabetic patients with that of general population by observed to expected death ratio(O/E ratio), infection was 7.8, congestive heart failure was 4.1, ischemic heart diease and cerebrovascular disease were 3.3 and 1.4 respectively. 3) When cerebrovascular disease, ischemic heart disease and congestive heart failure were defined together as cardiovascular disorder, O/E ratio was 2.0, and this is lower than that of infection. Conclusion: The large vessel disease is the most common cause of death in patients with non-insulin-dependent diabetes mellitus in Pusan, Korea. So, not only strict glycemic control, but detecting the risk factors related to large vessel disease and its control is important. This type of management may influence the diabetic's life expectancy ultimately, Generally, infection has been thought to be decreasing in recent years but, it is still one of the major cause of death in Korea. We have to detect infection early and treat it actively in non-insulin-dependent diabetic population.

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