수종과 암세포주와 섬유모세포주에서 taxol과 전리방사선이 세포독성과 prostaglandin생성에 미치는 영향

이건일,유동수,Lee Keon-Il,You Dong-Soo 대한영상치의학회 1998 Imaging Science in Dentistry Vol.28 No.1

The author evaluated the effects of taxol, a microtubular inhibitor, as a possible radiation sensitizer and the production of prostaglandins on three human cancer cell lines(KB, RPMI-2650 and SW-13) and one murine cell line(L929). Each cell line was divided into four groups (control, taxol only, radiation only and combination of taxol and radiation). The treatment consisted of a single irradiation of 10Gy and graded doses (5, 50, 100, 200, 300, 500 nM) of taxol for a 24-h period. The cytotoxicity of taxol alone was measured at 1 day after(1-day group) and 4 days after(4-day group) the treatment. The survival ratio of cell was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl) -2,5-dimethyl tetrazolium bromide) test. Prostaglandins(PGE2 and PGI2) were measured in the culture medium by a radioimmunoassay. The results obtained were as follows. 1. There was a significantly increased cytotoxicity of KB cells in 4-day group than those in I-day group. There was a high correlation between doses of taxol and cell viability in both groups(l-day group R=0.82741, 4-day group R=0.84655). 2. There was a significantly increased cytotoxicity of RPMI -2650 cells treated with high concentration of taxol in 4-day group than those in I-day group. Also there was a high correlation between doses of taxol and cell viability in 4-day group(R=0.93917). 3. There was a significantly increased cytotoxicity of SW-13 cells treated with high concentration of taxol in 4-day group than those in 1-day group. However no high correlation was observed between doses of taxol and cell viability in both groups(1-day group R=0.46362, 4-day group R=0.65425). 4. There was a significantly increased cytotoxicity of L929 cells treated with low concentration of taxol in 4-day group than those in 1-day group. At the same time, there was a low correlation between doses of taxol and cell viability in both groups(1-day group R=0.34237, 4-day group R=0.23381). 5. In I-day group of L929 cells, higher cytotoxicities were observed in the groups treated with 500 nM taxol than given 10 Gy radiation alone. L929 cells in I-day group alone showed a radiosensitizing effect by taxol.. 6. In addition to L929 cells, all cancer cells treated with a combination of taxol and radiation in 4-day group appeared to have some fragmented nuclei and to float on the medium. In addition, L929 cells appeared to be more confluent. 7. The level of PGE2 production was the highest in the contol KB cells. This appeared to increase in every experimental group of all three cancer cells except L929 cells. There was a significantly increased production of PGE2 in SW -13 cells treated with a combination taxol and radiation compared to the other experimental groups. 8. The level of PGE2 production in the control group of RPMI-Z650 cells was the highest. This appeared to increase in every experimental group of all cells except in SW-13 cells. This also increased significantly in RPMI-2650 cells treated with a combination of taxol and radiation compared to the other experimental groups.

계수공정영상의 비선형 대조도 증강효과에 관한 연구

이건일,진연화,Lee Keon-Il,Jin Yeun-Hwa 대한영상치의학회 1997 Imaging Science in Dentistry Vol.27 No.2

This study was performed to demonstrate the effect of linear or nonlinear contrast enhancement on subtraction images. Three different textures were radiograped on dental film. The first radiograph was taken without the presence of an object. the second, which showed trabucular bone, was taken of the molar area of a human. the third radiograph was taken of the coronal part of molars. Each film was digitized into a 1312 x 1024 pixel x 8 bit depth matrix by means of a Nikon 35 mm film scanner(LS-3510AF, Japan) with fixed gain and internal dark current correction to maintain constant illumination. The scanner was interfaced to a Macintosh Le ill computer(Apple Computer, Charlotte, N.C) This resulted in three pairs of images, including different textures-plain, bone and enamel. Digital regular, linearly and nonlinearly enhanced subtraction was performed. Computer software was ,used to simulate lesions in the shape of a 2D-Gaussian curve on each of a pair of images. The each subtraction images were presented in a random sequence to two groups of 10 observers(students and dentists). ROC analysis was used to compare observer performance. The following results were obtained ; 1. All of LCE subtraction, equalized subtraction and regular subtraction images of plain texture were diagnosed the best by far. 2. The data revealed a siginificant LCE effect in both the student group and the expert group. 3. Clinical expertise was a helphul factor for the observers in this study.

Water Flow Model을 이용한 에지 검출

이건일,김인권,정동욱,송정희,곽원기,박래홍,Lee, Geon-Il,Kim, In-Gwon,Jeong, Dong-Uk,Song, Jeong-Hui,Gwak, Won-Gi,Park, Rae-Hong 대한전자공학회 2001 電子工學會論文誌-SP (Signal processing) Vol.38 No.4

본 논문에서는 영상의 그래디언트 (gradient)를 구하여 그래디언트 값의 분포를 마치 3차원 지형과 같은 개념으로 간주하고 여기에 물이 흐르는 개념을 적용한 에지 (edge) 검출 방법을 제안하였다 영상에서 그래디언트 값이 큰 부분은 배경과 객체간의 에지라 볼 수 있으며, 이 에지에 물이 고이게 하기 위해서는 반전된 그래디언트 영상을 사용한다. 반전된 그래디언트 영상에서 물의 흐름을 기반으로 한 enhancing 작업과 국부적응 임계값 적용을 실시하여 잡음을 줄인 에지 영상을 찾는 방법을 제안한다. 합성영상과 실제영상에 대한실험을 통해 제안한 방법의 효율성을 검증하였다. In this paper, we propose a flew edge detection method based on water flow model, in which gradient image surface is considered as a 3-dimensional (3-D) geographical feature. The edges of the objects in the background can be detected by the large gradient magnitude areas and to make the edges immersed it is required to invert the gradient image. The proposed edge detector uses a water flow model based enhancement and locally adaptive thresholding technique applied to the inverted gradient image resulting in better noise performance. Computer simulations with a few synthetic and real images show that the Proposed method can extract edge contour effectively.

Fractal dimension과 2차원 푸리에변환을 이용한 수질골의 특성화에 관한 실험적 연구

이건일,Lee Keon Il 대한영상치의학회 1998 Imaging Science in Dentistry Vol.28 No.2

The purpose of this study was to investigate whether a radiographic estimate of osseous fractal dimension and power spectrum of 2D discrete Fourier transform is useful in the characterization of structural changes in bone. Ten specimens of bone were decalcified in fresh 50 ml solutions of 0.1 N hydrochloric acid solution at cummulative timed periods of 0 and 90 minutes. and radiographed from 0 degree projection angle controlled by intraoral parelleling device. I performed one-dimensional variance. fractal analysis of bony profiles and 2D discrete Fourier transform. The results of this study indicate that variance and fractal dimension of scan line pixel intensities decreased significantly in decalcified groups but Fourier spectral analysis didn't discriminate well between control and decalcified specimens.

방사선 사진과 디지털 영상에서 실험적 치근 이개부 병소의 감지도에 관한 연구

이건일,유형근,신형식,Lee Geon-Il,You Hyung-Keun,Shin Hyung-Shik 대한영상치의학회 1995 Imaging Science in Dentistry Vol.25 No.1

The aim of this study was to evaluate clinician's detectability in the diagnosis of bone loss in the bifurcation of mandibular molars on periapical radiographs and Digital images. Periapical radiographs were obtained of the first molars in 2 dry mandibles after preparation of bony defects corresponding to degree I, degree II and degree III buccal furcation involvements. The radiographs were randomly presented to 39 clinicians(1 oral radiologist, 4 periodontist, 34 general dentists) who were asked to determine the presence or absence of bone loss. Periapical films were digitized with a TV camera. Digital images were assessed by 15 clinicians(1 oral radiologist, 4 periodontist, 10 general dentists). I. the overall diagnostic accuracy of Digital images for detection of bone loss in the bifurcation of mandibular molars was higher than that of the periapical radiographs. 2. the largest increase in diagnostic accuracy was found between lesion grade II and III on both radiographs and Digital images(P<0.05). 3. there was no significant difference between the standard state and the controlled contrast state on Digital images. 4. the overall diagnostic accuracy of I radiologist and 4 periodontists was better than that of the general dentists for detecting bifurcation involvements.

탈회동종골인 KTBB와 Dembone의 이식효과에 관한 방사선학적 비교연구

이건일(KEONIL LEE),이종호(JONGHO LEE),이은영(EUNYOUNG LEE),엄인웅(INWOONG UM) 대한치과의사협회 2000 대한치과의사협회지 Vol.38 No.9

블록 분류와 적응적 필터링을 이용한 후처리에서의 양자화 잡음 제거 기법

이석환(Suk-Hwan Lee),권성근(Seoug-Geun Kwon),이종원(Jong-Won Lee),이승진(Seung-Jin Lee),이건일(Kuhn-Il Lee) 대한전자공학회 2000 대한전자공학회 학술대회 Vol.2000 No.6

Sequence-to-sequence 모델을 이용한 한국어 형태소 분석 및 품사 태깅

이건일(Jianri Li),이의현(Euihyeon Lee),이종혁(Jong-Hyeok Lee) 한국정보과학회 2016 한국정보과학회 학술발표논문집 Vol.2016 No.6

향신료와 야채류가 세균의 성장에 미치는 영향

이건일 ( G I Lee ) 대한임상검사과학회 1992 대한임상검사과학회지(KJCLS) Vol.24 No.1

This study was carried out to investigate the influence of food spices and vegetables, which are commonly available on the dining table everyday, on bacterial growth. Total 14 kinds of food spices and vegetables were .sampled in Kyungsan market in Kyungsan city. 7 strains of bacteria were used in this experiment as test strains which were 3 strains of Gram positive bacteria(Bacillus subtilis, Lactobacillus casei and Staphylococcus aureus) and Gram negative 4 strains(Enterobacter aerogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa and Shigella sp.). The results summerized were as follows : 1. The growth of all test strains except Pseudomonas aeruginosa was inhibited by water extracts of raw garlic with concentrations ranging 0.5% to 4.0%. 2. Bacillus subtilis, Klebsiella pneumoniae and Shigella sp. were not grown in tea with concentrations ranging 4.0% to 5.0%. 3. Water extracts of wormwood also interfered all strains growth except Bacillus subtilis of which inhibitory concentrations were ranged 2.0% to 10.0%. 4. In susceptibilities of test strains to NaCl solutions the most sensitive strain was Bacillus subtilis while Enterobacter aerogenes was showed strong resistance to each different concentration of this solution. Almost the growth of test strains except Enterobacter aerogenes were inhibited in over 4% of this solution. 5. Generally all of test strains were resisted to penicillin G whereas they all were susceptible only to streptomycin. Shigella sp. was markedly sensitive to all of antibiotics used in this experiment and MIC of this strain to them was 100 ,ug/ml while Pseudomonas aeruginosa was strongly tolerable to the all of antibiotics and its MIC to them was 400 + ,ug/ml. 6. Bacillus subtilis and Enterobacter aerogenes were able to grow until 85 ·c in gradually increasing temperature.

차선유지를 위한 다중차량 정보 기반의 가상도로 모델 생성

이건일(Geon Il Lee),강창묵(Chang Mook Kang),이승희(Seung-Hi Lee),정정주(Chung Choo Chung) 한국자동차공학회 2016 한국자동차공학회 학술대회 및 전시회 Vol.2016 No.11

Intelligent vehicle uses vision sensor to get road information for lane keeping control and adaptive cruise control of Autonomous driving vehicle control system. Such vision sensor has been known that it can provide poor detection performance due to unclear lane marks or obstacles. In this paper, we propose a virtual road model which uses Multi-vehicle information. The proposed model provided more improved performance than that considered in previous study which uses Ego-vehicle information. The performance of the proposed virtual road model is validated via experimental results.