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- 저자 : 윤태영 ( Jong Goo Kim (검색결과 4 건)
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비흑색종의 종양과 그 주위 상피 세포에서의 p53 , PCNA , bcl - 2에 대한 면역조직화학 염색 양상
김종구,윤태영,장승호 ( Jong Goo Kim,Tae Young Yoon,Seung Ho Chang ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.6
Background: In both normal tissue development and malignant cell growth, the maintenance of cell numbers reflects a balance between cell proliferation and cell death. Excessive growth may result from uncontrolled cellular proliferation or limited cell death. The growth process of squa mous cell carcinorna(SCC) has recently been reported to differ from that of basal cell carcinoma (BCC). Several reports have suggested that the normal-appearing, overlying epidermis might be a proliferative and be a precursor lesion of BCC. SCCs occur in burn scars, chronic ulcers, and chronic sinus but the najority of SCCs are actinic in origin. It. is possible to develop subsequent. skin cancer from the normal-appearing epidermis adjacent to SCC due to chronic sun-exposure. Objective : The purpose of this study was to investigate growth dynamics of non-melanorna skin cancers and characteristics, including the carcinogenic property, of the normal appearing epidermis overlying and acljacent to non rnelanoma skin cancers. Methods : We compared expressions for p53, PCNA, bcl 2, and TGF-a in 21 BCCs and 8 SCCs by irnmunohistochi.mical staining with a labelled strept,avidin biotin complex(LSAB) method. Results . The results were as follows. 1) Expressions for p53 and PCNA within the tumor remarkably increased and the distribution pattern of expression for p53 was not always consistent with that for PCNA. 2) An expression the bcl-2 was increased in half of the BCCs, but not in all of the SCCs. 3) The epidermis overlying the BCC showed increased expressions for p53, PCNA, and TGF-a. 4) The epidermis adjacent to the SCC showed increased expressions for p53, and PCNA in a few of cases. Conclusion : We suggest that a neoplastic transformatiqn in BCC is caused by extended cell survival rather than ini:reased cell proliferation, but in SCC it. is caused by other mechanisms, and that the proliferativ activity in the epiderrnis overlying BCC is different from the normal epidermis and maybe repr'sents carcinogenic activity of the epidermis. (Korean J Dermatol 19()7;35(6): 1110-1120)
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김종구 ( Jong Goo Kim ),윤태영 ( Tae Young Yoon ),장승호 ( Seung Ho Chang ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.3
Nail-patella-elbow syndrome is a relatively rare autosomal dominant disorder characterized by nail and skeletal defects, especially of the patella. The principal manifestations include hypoplastic or absent patellae, dysplastic finger-nails, dislocated radial heads with limited elbow motion, and often iliac horns. A less common but not infrequent manifestations are hereditary nephropathy and hyperpigmentation of the pupillary margin of the iris (Lester iris). A 17-year-old man was presented with abnormalities of both the 1st and 2nd finger-nails since birth. He had triangular lunulae and hypoplastic nail plates. Two months ago, the diagnosis of subluxation of both elbow joints was made as limitation of motion and radiologic findings of both knee joints revealed hypoplastic patellae. Routine laboratory studies were all within normal limits. The patient's father had triangular lunulae and hypoplastic nail plates on both 1st finger-nails. We report a case of nail -patella syndrome with the review of literature. (Kor J Dermatol 1996;34(3): 440-444)
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김종구,장승호,윤태영 ( Jong Goo Kim,Seung Ho Chang,Tae Young Yoon ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4
Dopamine, a sympathomimetic agent, is one of the drugs used to improve cardiac output and blood pressure in advanced cardiac life-support in the context of conditions such as shock and heart failure. It is available only for intravenous use. We report a case of dopamine gangrene which has never been reported in Korean medical literature. Four gangrenous lesions developed in both forearms and the left leg of a 72-year-old man during a 7-day infusion of dopamine 3pg per kg per minute as treatment for septic shock, which corresponded to the injection sites. The gangrenous lesions healed up spontaneously leaving scars after administration of dopamine was discontinued. (Kor J Dermatol 1997;35(4): 805 - 808)
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