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카페인 약리작용에 민감한 지원자와 둔감한 지원자 및 뚱뚱한 쥐와 마른 쥐에 대한 카페인 약물동태 비교
윤정옥(Jeong Ok Yun),권광일(Kwang Il Kwon) 대한약학회 1993 약학회지 Vol.37 No.4
To determine the reason of individual variation of the effect of caffeine, the absorption and the disposition of caffeine were studied in caffeine sensitive and caffeine nonsensitive volunteers. And also to study the effect of obesity on caffeine pharmacokinetics, the caffeine disposition in the obese rat and in the lean rat were investigated respectively. In result the caffeine sensitive group showed a longer terminal half-life of caffeine(7.35 +/- 0.71 hr : 5.49 +/- 0.73 hr) and a larger AUC (55.42 +/- 9.09mcg.ml-1.hr : 44.0 +/- 7.81 mcg.ml-1.hr) than that of caffeine non-sensitive group without statistical significance. The obese rat showed a longer terminal half-life (3.47 hr : 2.31 hr) and a larger AUC(35.3mcg.ml-1.hr : 26.97mcg.ml-1.hr) than that of the lean rat. But there was no correlation in the amount of daily caffeine consumption and obesity. In conclusion, we suggest that the individual variation of the effect of caffeine are being caused from the individual differences of caffeine susceptibility or tolerance rather than the differences of the genetic metabolic capacity or metabolic tolerance.
충북지역 당뇨 환자의 영양지식, 당뇨합병증 예방지식 및 관련된 요인
김기남(Ki Nam Kim),윤정옥(Jeong Ok Yun) 충북대학교 생활과학연구소 2009 생활과학연구논총 Vol.13 No.1
The purpose of this study was to investigate nutrition knowledge, preventive knowledge of diabetes complications and related factors among type 2 diabetic patients. The study subjects were 83 patients with type 2 diabetes, aged over 20, in Chungbuk area. The gender distribution of subjects was 53.0% males and 47.0% females, and BMI showed 30.1% overweight and 34.9% obesity. At the present time of study, 37.3% of the subjects had more than one complications and the symptom that took the highest frequency among diabetes complications was 'retinopathy'(27.5%). Mean score of nutrition knowledge and preventive knowledge of diabetes complications was 9.7 out of 15 and 7.5 out of 10 , respectively. Correlation by Pearson's coefficient between nutrition knowledge and preventive knowledge of diabetes complications showed high correlation(r=0.31, p<0.01). For the factors influencing diabetes control, a group with diabetes education showed significantly higher score of preventive knowledge about diabetes complications and better blood glucose control compared to the other group without education. In conclusion, diabetes education should be offered for diabetic patients in order to improve their diabetes knowledges and blood glucose control.